IMMUNOLOGICAL REAGENTS AND USES THEREFOR
First Claim
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1. A ligand which binds to MR1 wherein said binding results in binding of the MR1 to MAIT cells.
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Abstract
The present invention provides a ligand which binds to MR1 wherein said binding results in binding of the MR1 to MAIT cells.
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Citations
45 Claims
- 1. A ligand which binds to MR1 wherein said binding results in binding of the MR1 to MAIT cells.
- 11. An MR1-ligand subunit or multimeric complex thereof, wherein said subunit or multimeric complex binds to MAIT cells.
- 24. A method of modulating MAIT cell activity, said method comprising contacting said cell with an effective amount of the MR1 ligand subunit or multimeric complex thereof for a time and under conditions sufficient to modulate the interaction of MAIT cells with MR1 wherein promoting or otherwise agonizing said interaction up-regulates said MAIT cell activity and inhibiting or otherwise antagonizing said interaction down-regulates said MAIT cell activity.
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34. A method of detecting the presence of MAIT cells in a biological sample from a subject, the method comprising the steps of a) contacting the biological sample with antigen presenting cells expressing MR1 bound to a ligand or a soluble form thereof, under conditions that would allow binding of the MR1 with MAIT cells present in the sample;
- and b) detecting the presence of MAIT cell bound MR1 in the biological sample.
- View Dependent Claims (35, 36)
- 37. A method for the treatment and/or prophylaxis of a disease or condition in a mammal, said method comprising administering to said mammal an effective amount of an MR1 ligand subunit or multimeric complex thereof for a time and under conditions sufficient to modulate the interaction of MAIT cells with MR1, wherein promoting or otherwise agonizing said interaction up-regulates said MAIT cell activity and inhibiting or otherwise antagonizing said interaction down-regulates said MAIT cell activity.
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Specification