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MULTISPECIFIC ANTIBODIES

  • US 20150166670A1
  • Filed: 11/24/2014
  • Published: 06/18/2015
  • Est. Priority Date: 05/24/2012
  • Status: Abandoned Application
First Claim
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1. A multispecific antibody, comprising:

  • A) a) the light chain and heavy chain of a full length antibody which specifically binds to a first antigen and second antigen; and

    b) the modified light chain and modified heavy chain of a full length antibody which specifically binds to a third antigen, wherein the variable domains VL and VH are replaced by each other, and/or wherein the constant domains CL and CH1 are replaced by each other;

    orB) a) the light chain and heavy chain of a full length antibody which specifically binds to a first antigen; and

    b) the modified light chain and modified heavy chain of a full length antibody which specifically binds to a second antigen and third antigen, wherein the variable domains VL and VH are replaced by each other, and/or wherein the constant domains CL and CH1 are replaced by each other;

    orC) a) the light chain and heavy chain of a full length antibody which specifically binds to a first antigen and a second antigen; and

    b) the modified light chain and modified heavy chain of a full length antibody which specifically binds to a third antigen and fourth antigen, wherein the variable domains VL and VH are replaced by each other, and/or wherein the constant domains CL and CH1 are replaced by each other; and

    wherein the antibody is a bivalent, tri- or tetraspecific antibody.

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