FUSIONS OF CAS9 DOMAINS AND NUCLEIC ACID-EDITING DOMAINS
First Claim
1. A fusion protein comprising(i) a nuclease-inactive Cas9 domain;
- and(ii) a nucleic acid-editing domain.
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Abstract
Some aspects of this disclosure provide strategies, systems, reagents, methods, and kits that are useful for the targeted editing of nucleic acids, including editing a single site within the genome of a cell or subject, e.g., within the human genome. In some embodiments, fusion proteins of Cas9 and nucleic acid editing enzymes or enzyme domains, e.g., deaminase domains, are provided. In some embodiments, methods for targeted nucleic acid editing are provided. In some embodiments, reagents and kits for the generation of targeted nucleic acid editing proteins, e.g., fusion proteins of Cas9 and nucleic acid editing enzymes or domains, are provided.
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Citations
14 Claims
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1. A fusion protein comprising
(i) a nuclease-inactive Cas9 domain; - and
(ii) a nucleic acid-editing domain. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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Specification