COMPOUNDS FOR TARGETED IMMUNOTHERAPY
First Claim
Patent Images
1. A compound having the structure of Formula (I):
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TM-Ln-AM
(I),wherein TM is a targeting moiety, AM is an activating moiety that is capable of activating a human dendritic cell, NK cell, macrophage, or tumor cell, or a combination thereof, Ln is a linker, and n is an integer selected from 0 and 1,with the proviso that when TM comprises an antibody, AM does not comprise a CpG oligonucleotide.
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Abstract
Compounds for targeted immunotherapy, compositions comprising the compounds and use of the compounds in the treatment of diseases such as cancer are disclosed. The compounds having the structure of formula TM-Ln-AM, wherein TM is a targeting moiety, AM is an activating moiety that is capable of activating a human dendritic cell, NK cell, or tumor cell, or a combination thereof, Ln is a linker, and n is an integer selected from 0 and 1.
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Citations
41 Claims
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1. A compound having the structure of Formula (I):
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TM-Ln-AM
(I),wherein TM is a targeting moiety, AM is an activating moiety that is capable of activating a human dendritic cell, NK cell, macrophage, or tumor cell, or a combination thereof, Ln is a linker, and n is an integer selected from 0 and 1, with the proviso that when TM comprises an antibody, AM does not comprise a CpG oligonucleotide. - View Dependent Claims (2, 3, 5, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 22, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 38, 39, 40)
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Specification