Filler Fluids for Droplet Operations
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Abstract
The present invention relates to filler fluids for droplet operations. According to one embodiment of this aspect, a droplet microactuator is provided and includes: (a) a first substrate comprising electrodes configured for conducting droplet operations on a surface of the substrate; (b) a second substrate spaced from the surface of the substrate by a distance sufficient to define an interior volume between the first substrate and second substrate, wherein the distance is sufficient to contain a droplet disposed in the space on the first substrate; and (c) a droplet arranged in the interior volume and arranged with respect to the electrodes in a manner which permits droplet operations to be effected on the droplet using the electrodes.
5 Citations
109 Claims
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1-45. -45. (canceled)
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46. A droplet microactuator comprising:
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(a) a first substrate comprising electrodes configured to effect electrowetting mediated droplet operations on a surface of the first substrate; (b) a second substrate spaced from the surface of the first substrate by a distance sufficient to define an interior volume between the first substrate and the second substrate; and (c) a droplet and a filler fluid in the interior volume, wherein the droplet is surrounded by the filler fluid, and arranged with respect to the electrodes in a manner which permits electrowetting mediated droplet operations to be effected on the droplet using the electrodes, wherein the filler fluid comprises an oil and a surfactant, and wherein the surfactant comprises nonionic low hydrophile-lipophile balanced (HLB) surfactant with an HLB less than about 10. - View Dependent Claims (47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64)
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65. A droplet microactuator comprising:
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(a) a first substrate comprising electrodes configured to effect electrowetting mediated droplet operations on a surface of the first substrate; (b) a second substrate spaced from the surface of the first substrate by a distance sufficient to define an interior volume between the first substrate and the second substrate; and (c) a droplet and a filler fluid in the interior volume, wherein the droplet is surrounded by the filler fluid, and arranged with respect to the electrodes in a manner which permits electrowetting mediated droplet operations to be effected on the droplet using the electrodes, wherein the filler fluid comprises an oil and a surfactant, and wherein the surfactant is a nonionic low hydrophile-lipophile balanced (HLB) surfactant or a nonionic lipophile surfactant. - View Dependent Claims (66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84)
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85. A droplet microactuator comprising:
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(a) a first substrate comprising electrodes configured to effect electrowetting mediated droplet operations on a surface of the first substrate; (b) a second substrate spaced from the surface of the first substrate by a distance sufficient to define an interior volume between the first substrate and the second substrate; and (c) a droplet and a filler fluid in the interior volume, wherein the droplet comprises whole blood and is surrounded by the filler fluid, and arranged with respect to the electrodes in a manner which permits electrowetting mediated droplet operations to be effected on the droplet using the electrodes, wherein the filler fluid comprises an oil and a surfactant, and wherein the surfactant comprises nonionic low hydrophile-lipophile balanced (HLB) surfactant with an HLB less than about 2. - View Dependent Claims (86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, 100, 101)
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102. A droplet microactuator comprising:
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(a) a first substrate comprising electrodes configured to effect electrowetting mediated droplet operations on a surface of the first substrate; (b) a second substrate spaced from the surface of the first substrate by a distance sufficient to define an interior volume between the first substrate and the second substrate; and (c) a droplet and a filler fluid in the interior volume, wherein the droplet comprises whole blood and is surrounded by the filler fluid, and arranged with respect to the electrodes in a manner which permits electrowetting mediated droplet operations to be effected on the droplet using the electrodes, wherein the filler fluid comprises an oil and a surfactant, and wherein the oil comprises a silicone oil and the surfactant comprises a nonionic lipophile surfactant. - View Dependent Claims (103, 104, 105, 107, 108, 109)
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106. The droplet microactuator of claim 113 wherein the droplet comprises whole blood.
Specification