ADSORPTION METHOD, ADSORPTION SEPARATION METHOD, AND DRUG DELIVERY CARRIER

• US 20150182876A1
• Filed: 03/16/2015
• Published: 07/02/2015
• Est. Priority Date: 09/18/2012
• Status: Active Grant

• Current Assignee: Koito Manufacturing Company Limited
• Original Assignee: Koito Manufacturing Company Limited
• Inventors: ENOMOTO, Kiminori, DAICHO, Hisayoshi, SHINOMIYA, Yu
• Granted Patent: US 9,795,896 B2
• Time in Patent Office: Days
• US Class Current: 1/1
• CPC Class Codes: A61K 47/02 Inorganic compounds
• CPC Class Codes: A61K 9/0092 Hollow drug-filled fibres, tubes of the core-shell type, coated fibres, coated rods, microtubules or nanotubes
• CPC Class Codes: A61K 9/70 Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug hollow drug-filled fibres A61K9/0092
• CPC Class Codes: B01D 15/36 involving ionic interaction
• CPC Class Codes: B01D 15/362 Cation-exchange
• CPC Class Codes: B01J 20/0207 Compounds of Sc, Y or Lanthanides
• CPC Class Codes: B01J 20/0292 Phosphates of compounds other than those provided for in B01J20/048
• CPC Class Codes: B01J 20/048 containing phosphorus, e.g. phosphates, apatites, hydroxyapatites
• CPC Class Codes: B01J 20/28004 Sorbent size or size distribution, e.g. particle size
• CPC Class Codes: B01J 20/28042 Shaped bodies; Monolithic structures
• CPC Class Codes: B01J 20/3071 Washing or leaching
• CPC Class Codes: B01J 20/3078 Thermal treatment, e.g. calcining or pyrolizing
• CPC Class Codes: C01B 25/32 Phosphates of magnesium, calcium, strontium, or barium

Abstract

An adsorption method adsorbs a substance by using a tube-shaped apatite crystal. The apatite crystal may be a monocrystal given by a general formula M²₅(PO₄)₃X (M² denotes at least one element selected from the group consisting of divalent alkali earth metal and Eu, and X denotes at least one element or molecule selected from the group consisting of halogen element and OH). The outer form of the apatite crystal may be a hexagonal prism in which the aperture of a hole formed on a top surface or bottom surface of the hexagonal prism may be hexagonal.

Claims

1. An adsorption method for adsorbing a substance by using a tube-shaped apatite crystal.

2. The adsorption method of adsorbing according to claim 1, wherein

the apatite crystal is a monocrystal given by a general formula M²₅(PO₄)₃X (M² denotes at least one element selected from the group consisting of divalent alkali earth metal and Eu, and X denotes at least one element or molecule selected from the group consisting of halogen element and OH).

3. The adsorption method according to claim 1, wherein

a monocrystal given by a general formula M²₅(PO₄)₃OH (M² denotes at least one element selected from the group consisting of divalent alkali earth metal and Eu) is used to adsorb protein or amino acid.

4. The adsorption method according to claim 1, wherein

the outer form of the apatite crystal is a hexagonal prism in which the aperture of a hole formed on a top surface or bottom surface of the hexagonal prism is hexagonal.

5. The adsorption method according to claim 1, wherein

the inner diameter of the tube-shaped apatite crystal is 10 nm to 10 μ

m.

6. An adsorption separation method comprising:

adsorbing protein or amino acid by using a tube-shaped apatite crystal; and

causing the apatite crystal on which the protein or amino acid is adsorbed to contact an aqueous chloride solution, and selectively isolating the adsorbed protein or amino acid.

7. A drug delivery carrier comprising a tube-shaped apatite crystal and a drug carried by the tube-shaped apatite crystal.

8. The drug delivery carrier according to claim 7, wherein

the drug is carried inside the tube-shaped apatite crystal.

9. The drug delivery carrier according to claim 7, wherein

the apatite crystal is a monocrystal given by a general formula M²₅(PO₄)₃X (M² denotes at least one element selected from the group consisting of divalent alkali earth metal and Eu, and X denotes at least one element or molecule selected from the group consisting of halogen element and OH).

10. The drug delivery carrier according to claim 7, wherein

the inner diameter of the tube-shaped apatite crystal is 10 nm to 50 μ

m.