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METHODS AND COMPOSITIONS FOR GENERATION OF GERMLINE HUMAN ANTIBODY GENES

  • US 20150183853A1
  • Filed: 07/09/2014
  • Published: 07/02/2015
  • Est. Priority Date: 09/09/2003
  • Status: Abandoned Application
First Claim
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1. A method for producing a polynucleotide encoding a human germline antibody V-region, comprising the steps of:

  • (a) obtaining a V minigene or a J minigene; and

    (b) joining the V minigene with at least one J minigene, or joining the J minigene with a V minigene, wherein the J minigene is located at the 3′

    end of the V minigene.

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