METHODS AND DEVICES FOR REMOTE ISCHEMIC CONDITIONING VIA PARTIAL LIMB OCCLUSION
First Claim
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1. A device for delivery of remote ischemic conditioning treatment to a subject, said device comprising:
- a cuff configured for placement over a limb of the subject, said cuff is further configured to at least partially reduce blood flow in said limb upon inflation thereof;
a controller operably connected to said cuff, said controller is configured upon activation to deliver said remote ischemic conditioning treatment by performing a plurality of remote ischemic conditioning treatment cycles, each treatment cycle comprising;
a period of cuff inflation when said controller is causing said cuff to be inflated to and maintained at or above a pressure sufficient to cause at least a partial reduction of blood flow in said limb to produce an ischemic stress therein for at least about one minute, anda period of cuff deflation when said controller is causing said cuff to deflate so as to increase blood flow in said limb and relieve said ischemic stress,wherein said ischemic stress is sufficient to cause said remote ischemic conditioning treatment, said controller is further configured to avoid complete occlusion of said limb by said cuff lasting more than about one minute during at least one of said treatment cycles.
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Abstract
Single- or dual-bladder devices for automated delivery of remote ischemic conditioning treatment via partial limb occlusion involve various methods of operating the cuff in which partial or full limb occlusion is achieved during the periods of cuff inflation. Achieving clinical benefits of remote ischemic conditioning without extended cessation of limb blood flow are advantageous due to lower required cuff pressure and reduced risk of clot formation in the limb vasculature.
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Citations
21 Claims
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1. A device for delivery of remote ischemic conditioning treatment to a subject, said device comprising:
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a cuff configured for placement over a limb of the subject, said cuff is further configured to at least partially reduce blood flow in said limb upon inflation thereof; a controller operably connected to said cuff, said controller is configured upon activation to deliver said remote ischemic conditioning treatment by performing a plurality of remote ischemic conditioning treatment cycles, each treatment cycle comprising; a period of cuff inflation when said controller is causing said cuff to be inflated to and maintained at or above a pressure sufficient to cause at least a partial reduction of blood flow in said limb to produce an ischemic stress therein for at least about one minute, and a period of cuff deflation when said controller is causing said cuff to deflate so as to increase blood flow in said limb and relieve said ischemic stress, wherein said ischemic stress is sufficient to cause said remote ischemic conditioning treatment, said controller is further configured to avoid complete occlusion of said limb by said cuff lasting more than about one minute during at least one of said treatment cycles. - View Dependent Claims (2, 3)
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4. A device for delivery of remote ischemic conditioning treatment to a subject, said device comprising:
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a cuff configured for placement over a limb of the subject, said cuff is further configured to at least partially reduce blood flow in said limb upon inflation thereof; a controller operably connected to said cuff, said controller is configured upon activation to deliver said remote ischemic conditioning treatment by performing a plurality of remote ischemic conditioning treatment cycles, each treatment cycle comprising; a period of cuff inflation when said controller is causing said cuff to inflate to a pressure sufficient to at least partially reduce blood flow in said limb and produce an ischemic stress therein causing said remote ischemic conditioning, said period of cuff inflation lasting at least about one minute, and a period of cuff deflation when said controller is causing said cuff to deflate and increase blood flow in said limb to relieve said ischemic stress, wherein during at least one of said periods of cuff inflation said controller is further configured to vary pressure in said cuff so as to increase or decrease said ischemic stress in said limb. - View Dependent Claims (5, 6)
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7. A device for delivery of remote ischemic conditioning treatment to a subject, said device comprising:
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a cuff configured for placement over a limb of the subject, said cuff is further configured upon inflation to compress said limb to at least partially reduce blood flow therein; a controller operably connected to said cuff, said controller is configured upon activation to inflate and deflate said cuff to deliver said remote ischemic conditioning treatment via performing a plurality of remote ischemic conditioning treatment cycles, each treatment cycle comprising; a cuff inflation period wherein said cuff is inflated to a pressure sufficient to reduce blood flow in said limb and cause an ischemic stress therein to reach or exceed a predetermined ischemic stress threshold, said cuff inflation period lasting at least about one minute, and a cuff deflation period wherein said cuff is deflated to increase blood flow in said limb and relieve said ischemic stress therein, wherein said controller is further configured to avoid complete occlusion of blood flow in said limb by said cuff lasting more than about one minute during at least one of said treatment cycles. - View Dependent Claims (8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21)
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Specification