OX40L FUSION PROTEIN FOR THE IMMUNOTHERAPY OF TUMORS OF VETERINARY ANIMALS
First Claim
1. An isolated recombinant polypeptide comprising an immunoglobulin domain and a canine OX40L extracellular domain polypeptide, wherein the canine OX40L extracellular domain polypeptide comprises from about amino acid 447 to about amino acid 698 of a polypeptide of SEQ ID NO:
- 2, or about amino acid 332 to about amino acid 464 of a polypeptide of SEQ ID NO;
3, or a biological equivalent of each thereof.
0 Assignments
0 Petitions
Accused Products
Abstract
Provided is an isolated recombinant polypeptide comprising an immunoglobulin domain and a canine OX40L extracellular domain polypeptide fragment or a biological equivalent thereof and compositions comprising: an isolated recombinant polypeptide comprising an immunoglobulin domain and a canine OX40L extracellular domain polypeptide fragment; and a pharmaceutically acceptable carrier. Also provided are methods for treating or ameliorating the symptoms of cancer in a canine comprising administering an effective amount of the isolated recombinant polypeptide of the disclosure and/or a composition of the disclosure to a canine in need thereof.
29 Citations
44 Claims
-
1. An isolated recombinant polypeptide comprising an immunoglobulin domain and a canine OX40L extracellular domain polypeptide, wherein the canine OX40L extracellular domain polypeptide comprises from about amino acid 447 to about amino acid 698 of a polypeptide of SEQ ID NO:
- 2, or about amino acid 332 to about amino acid 464 of a polypeptide of SEQ ID NO;
3, or a biological equivalent of each thereof. - View Dependent Claims (2, 3, 4, 5, 6, 7, 9, 10, 11, 12, 13, 14, 15, 20, 22, 27, 34, 35, 44)
- 2, or about amino acid 332 to about amino acid 464 of a polypeptide of SEQ ID NO;
-
8. An isolated recombinant polypeptide comprising SEQ ID NO:
- 2, or SEQ ID NO;
3, or a biological equivalent of each thereof.
- 2, or SEQ ID NO;
-
16-19. -19. (canceled)
-
21. (canceled)
-
23-26. -26. (canceled)
-
28-33. -33. (canceled)
-
36-43. -43. (canceled)
Specification