Implantable Sensor and Method for Such Sensor

• US 20150196224A1
• Filed: 01/16/2014
• Published: 07/16/2015
• Est. Priority Date: 01/16/2014
• Status: Abandoned Application

• Current Assignee: D.T.R. Dermal Therapy Research Inc.
• Original Assignee: Dermal Therapy (Barbados) Inc.
• Inventors: RUSU, Ana, RODRIGUEZ DUENAS, Saul Alejandro, OLLMAR, Stig
• Application Number:
  US14/157,298
• Publication Number:
  US 20150196224A1
• Time in Patent Office: Days
• US Class Current: 1/1
• CPC Class Codes: A61B 10/0012 Ovulation-period determination for animals A61D17/002
• CPC Class Codes: A61B 2010/0016 based on measurement of electric currents, e.g. conductivity tests
• CPC Class Codes: A61B 2503/22 Motor vehicles operators, e.g. drivers, pilots, captains
• CPC Class Codes: A61B 2560/0219 of externally powered implanted units
• CPC Class Codes: A61B 5/0022 Monitoring a patient using a global network, e.g. telephone networks, internet
• CPC Class Codes: A61B 5/0031 Implanted circuitry
• CPC Class Codes: A61B 5/01 Measuring temperature of body parts ; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue clinical contact thermometers G01K13/20
• CPC Class Codes: A61B 5/053 Measuring electrical impedance or conductance of a portion of the body
• CPC Class Codes: A61B 5/0537 Measuring body composition by impedance, e.g. tissue hydration or fat content
• CPC Class Codes: A61B 5/0538 invasively, e.g. using a catheter
• CPC Class Codes: A61B 5/076 Permanent implantations telemetry using implanted circuitry A61B5/0031; implanted stimulators for therapy A61N1/3605, A61N1/362, A61N1/372
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14539 for measuring pH
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/14551 for measuring blood gases
• CPC Class Codes: A61B 5/413 Monitoring transplanted tissue or organ, e.g. for possible rejection reactions after a transplant
• CPC Class Codes: A61B 5/4318 Evaluation of the lower reproductive system A61B5/4343 takes precedence
• CPC Class Codes: A61B 5/4878 Evaluating oedema
• CPC Class Codes: A61B 5/6867 specially adapted to be attached or implanted in a specific body part A61B5/6847 takes precedence
• CPC Class Codes: A61B 5/7225 Details of analog processing, e.g. isolation amplifier, gain or sensitivity adjustment, filtering, baseline or drift compensation A61B5/30, A61B5/316 take precedence; transformers for specific applications H01F38/00; amplifiers H03F
• CPC Class Codes: A61B 5/7228 : Signal modulation applied to the input signal sent to patient or subject; demodulation to recover the physiological signal modulation H03C

Abstract

The present invention relates to an implantable sensor configured to be implanted within the body of the subject and being configured to measure impedance within a body tissue of the subject resulting from an electrical current flowing through the body tissue, wherein the body tissue is sub-dermal or subcutaneous tissue of the subject. One pair of injection electrodes is configured for injection of electrical current into the body tissue and one pair of sensing electrodes is configured to detect the resulting voltage. A detector is operatively connected to the sensing electrodes and is configured to receive the voltage detected by the sensing electrodes, wherein the detector is configured to measure the impedance of the body tissue based on the voltage detected by the pair of sensing electrodes. A microcontroller is operatively connected to the detector and is configured to receive impedance signals from the detector and to provide control signals to the current signal output circuit and a powering and communication circuit including a coil configured to be powered by an electromagnetic field produced by an external coil.

Claims

1. A device for measuring impedance in a subject, the device being configured to be implanted within the body of the subject and being configured to measure impedance within a body tissue of the subject resulting from an electrical current flowing through the body tissue, wherein the body tissue is sub-dermal or subcutaneous tissue of the subject, comprising:

one pair of injection electrodes configured for injection of electrical

current into the body tissue, wherein the electrical current is passed from one of the injection electrodes to the other of the injection electrodes through the body;

one pair of sensing electrodes configured to detect the resulting

voltage caused by the current flowing between the pair of injection electrodes and through the body tissue;

a current signal output circuit operatively connected to the microcontroller and the injection electrodes and being configured to provide electrical current at predetermined frequencies to the injection electrodes;

a detector operatively connected to the sensing electrodes and configured to receive the voltage detected by the sensing electrodes, wherein the detector is configured to measure the impedance of the body tissue based on the voltage detected by the pair of sensing electrodes;

a microcontroller operatively connected to the detector and being configured to receive impedance signals from the detector and to provide control signals to the current signal output circuit; and

a powering and communication circuit including a coil configured to be powered by an electromagnetic field produced by an external coil, the powering circuit being operatively connected to the microcontroller and configured to power the microcontroller, the current signal output circuit and the detector.

2. The device according to claim 1, wherein the detector comprises a I/Q (In-phase/Quadrature) demodulator comprising one signal path for extraction of the I and Q components, respectively, wherein a sensed voltage is received from the sensing electrodes as input and an output of the I/Q demodulator is at least one DC signal.

3. The device according to claim 1, wherein the device is configured to measure or monitor at least one physiological parameter of the body of the subject, wherein a monitoring engine is configured to correlate the measured impedance with a predetermined relationship between impedance and a at least one physiological parameter.

4. The device according to claim 3, wherein the microcontroller is operatively connected to the detector and being programmed to determine the physiological parameter in the subject by correlating the measured impedance with a predetermined relationship between impedance and levels of the at least one physiological parameter.

5. The device according to claim 4, wherein the microcontroller is programmed to determine a glucose level in the subject by correlating the measured impedance with a predetermined relationship between impedance and blood glucose levels.

6. The device according to claim 3, wherein the microcontroller is configured to communicate the measured impedance to an external device via the powering and communication circuit and wherein the monitoring engine is arranged in the external device.

7. The device according to claim 3, wherein the microcontroller is configured to communicate the measured impedance to an external device via the powering and communication circuit and wherein the monitoring engine is arranged in the external device and is configured to determine a glucose level in the subject by correlating the measured impedance with a predetermined relationship between impedance and blood glucose levels.

8. The device according to claim 3, wherein the at least one physiological parameter include body temperature, hydration levels, hormone levels, lactate levels.

9. The device according to claim 1, wherein the current signal output circuit is configured to provide the injected current at a plurality of frequencies in a range between 1 kHz to 3 MHz, and preferably within a range between 1.5 kHz and 2.5 MHz, and more preferably in a range between 1.90 kHz and 2 MHz.

10. The device according to claim 1, further comprising a frequency generation circuit operatively connected to the detector and being configured to generate reference signals having a frequency between 5 kHz to 50 MHz, and preferably in a range between 10 kHz to 20 MHz and more preferably in a range between 16 kHz to 16 MHz, and to deliver the reference signals to the detector.

11. The device according to claim 2, wherein the I/Q demodulator comprises a multiplier configured to multiply the received voltage with the reference signal.

12. The device according to claim 1, wherein the detector further comprises a voltage amplifier for amplifying the voltage sensed by the sensing electrodes.

13. The device according to claim 1, wherein the detector further comprises a low pass filter for filtering the amplified signals.

14. The device according to claim 1, wherein the device is configured to be implanted within the body of the subject sub-dermally or subcutaneously

15. The device according to claim 1, wherein the powering and communication circuit is configured to communicate with an external communication device using a back-scattering technique.

16. A method for measuring impedance in a subject using a device being configured to be implanted within the body of the subject and being configured to measure impedance within a body tissue of the subject resulting from an electrical current flowing through the body tissue, wherein the body tissue is sub-dermal or subcutaneous tissue of the subject, comprising:

providing power for the impedance measurement by receiving power at a coil via an electromagnetic field produced by an external coil;

injecting electrical current into the body tissue via one pair of injection

electrodes, wherein the electrical current is passed from one of the injection electrodes to the other of the injection electrodes through the body;

sensing the resulting voltage caused by the current flowing between the pair of injection electrodes and through the body tissue at one pair of sensing electrodes; and

determining the impedance of the body tissue based on the voltage detected by the pair of sensing electrodes.

17. The method according to claim 16, further comprising performing I/Q (In-phase/Quadrature) demodulation on one signal path for extraction of the I and Q components, respectively, wherein a sensed voltage is received from the sensing electrodes as input and an output of the I/Q demodulation is at least one DC signal.

18. The method according to claim 16, further comprising measuring or monitoring at least one physiological parameter of the body of the subject by correlating the measured impedance with a predetermined relationship between impedance and a at least one physiological parameter.

19. The method according to claim 18, further comprising determining a glucose level in the subject by correlating the measured impedance with a predetermined relationship between impedance and blood glucose levels.

20. The method according to claim 18, further comprising communicating the measured impedance to an external device via the coil using electromagnetic fields.

21. The method according to claim 18, wherein the at least one physiological parameter include body temperature, hydration levels, hormone levels, lactate levels, pH, pO2, other specific ions or molecules, local pressure inside brain or scull.

22. The method according to claim 16, further comprising providing current for the injection electrodes at a plurality of frequencies in a range between 1 kHz to 3 MHz, and preferably within a range between 1.5 kHz and 2.5 MHz, and more preferably in a range between 1.90 kHz and 2 MHz.

23. The method according to claim 16, further comprising generating reference signals having a frequency between 5 kHz to 50 MHz, an preferably in a range between 10 kHz to 20 MHz and more preferably in a range between 16 kHz to 16 MHz.

24. A device for measuring impedance in an object, the device being

configured to be implanted within the object or attached to the object and being configured to measure impedance of the object resulting from an electrical current flowing through the body tissue, comprising:

one pair of injection electrodes configured for injection of electrical

current into the object, wherein the electrical current is passed from one of the injection electrodes to the other of the injection electrodes through the object;

one pair of sensing electrodes configured to detect the resulting

voltage caused by the current flowing between the pair of injection electrodes and through the object;

a current signal output circuit operatively connected to the microcontroller and the injection electrodes and being configured to provide electrical current at predetermined frequencies to the injection electrodes;

a detector operatively connected to the sensing electrodes and configured to receive the voltage detected by the sensing electrodes, wherein the detector is configured to measure the impedance of the object based on the voltage detected by the pair of sensing electrodes;

a microcontroller operatively connected to the detector and being configured to receive impedance signals from the detector and to provide control signals to the current signal output circuit; and

a powering and communication circuit including a coil configured to be powered by an electromagnetic field produced by an external coil, the powering circuit being operatively connected to the microcontroller and configured to power the microcontroller, the current signal output circuit and the detector.

25. The device according to claim 24, wherein the object is an organ intended for transplantation, or a section of the female reproductory tract.

26. The device according to claim 24, wherein the detector comprises a I/Q (In-phase/Quadrature) demodulator comprising one signal path for extraction of the I and Q components, respectively, wherein a sensed voltage is received from the sensing electrodes as input and an output of the I/Q demodulator is at least one DC signal.

27. The device according to claim 24, wherein the device is configured to measure or monitor at least one physiological parameter of the object, wherein a monitoring engine is configured to correlate the measured impedance with a predetermined relationship between impedance and a at least one physiological parameter.

28. The device according to claim 27, wherein the monitoring engine is configured to monitor a fertility cycle and to determine a fertility status.

29. The device according to claim 27, wherein the microcontroller is operatively connected to the detector and being programmed to determine the physiological parameter in the object by correlating the measured impedance with a predetermined relationship between impedance and levels of the at least one physiological parameter.

30. The device according to claim 27, wherein the microcontroller is configured to communicate the measured impedance to an external device via the powering and communication circuit and wherein the monitoring engine is arranged in the external device.

31. The device according to claim 27, wherein the microcontroller is configured to communicate the measured impedance to an external device via the powering and communication circuit and wherein the monitoring engine is arranged in the external device and is configured to determine a glucose level in the subject by correlating the measured impedance with a predetermined relationship between impedance and blood glucose levels.

32. The device according to claim 24, wherein the current signal output circuit is configured to provide the injected current at a plurality of frequencies in a range between 1 kHz to 3 MHz, and preferably within a range between 1.5 kHz and 2.5 MHz, and more preferably in a range between 1.90 kHz and 2 MHz.

33. The device according to claim 24, further comprising a frequency generation circuit operatively connected to the detector and being configured to generate reference signals having a frequency between 5 kHz to 50 MHz, and preferably in a range between 10 kHz to 20 MHz and more preferably in a range between 16 kHz to 16 MHz, and to deliver the reference signals to the detector.

34. The device according to claim 26, wherein the I/Q demodulator comprises a multiplier configured to multiply the received voltage with the reference signal.

35. The device according to claim 24, wherein the detector further comprises a voltage amplifier for amplifying the voltage sensed by the sensing electrodes.

36. The device according to claim 24, wherein the detector further comprises a low pass filter for filtering the amplified signals.

37. The device according to claim 24, wherein the device is configured to be implanted within the body of the subject sub-dermally or subcutaneously

38. The device according to claim 24, wherein the powering and communication circuit is configured to communicate with an external communication device using a back-scattering technique.