SYSTEMS, METHODS AND COMPOSITIONS FOR IMPROVED TREATMENT OF ACIDOSIS
First Claim
1. A system for treating an acidotic patient, comprising:
- an intravenous-fluid supply system;
an automated fluid mixer and dispenser connected to said intravenous-fluid supply system to receive at least one supply fluid therefrom;
an electronic control system configured to communicate with said automated fluid mixer and dispenser; and
an intravenous line fluidly connected to said automated fluid mixer and dispenser, said intravenous line comprising an intravenous connecter configured for injecting intravenous fluid dispensed from said automated fluid mixer and dispenser intravenously into said acidotic patient,wherein said electronic control system is configured to control at least one of a total volume or a flow rate of said intravenous fluid to be injected into said acidotic patient'"'"'s blood based on at least a measured pH of said acidotic patient'"'"'s blood and based on a composition of said at least one supply fluid.
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Accused Products
Abstract
A system for treating an acidotic patient includes an intravenous-fluid supply system, an automated fluid mixer and dispenser connected to the intravenous-fluid supply system to receive at least one supply fluid therefrom, an electronic control system configured to communicate with the automated fluid mixer and dispenser, and an intravenous line fluidly connected to the automated fluid mixer and dispenser. The intravenous line includes an intravenous connecter configured for injecting intravenous fluid dispensed from the automated fluid mixer and dispenser intravenously into the acidotic patient. The electronic control system is configured to control at least one of a total volume or a flow rate of the intravenous fluid to be injected into the acidotic patient'"'"'s blood based on at least a measured pH of the acidotic patient'"'"'s blood and based on a composition of the at least one supply fluid. An intravenous solution for treating acidosis includes sodium bicarbonate and at least one of disodium carbonate, sodium hydroxide, and tris(hydroxymethyl)aminomethane dissolved in an aqueous solution. The intravenous solution has a pH of at least 10 and a total concentration of osmolites within a near isotonic range.
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Citations
28 Claims
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1. A system for treating an acidotic patient, comprising:
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an intravenous-fluid supply system; an automated fluid mixer and dispenser connected to said intravenous-fluid supply system to receive at least one supply fluid therefrom; an electronic control system configured to communicate with said automated fluid mixer and dispenser; and an intravenous line fluidly connected to said automated fluid mixer and dispenser, said intravenous line comprising an intravenous connecter configured for injecting intravenous fluid dispensed from said automated fluid mixer and dispenser intravenously into said acidotic patient, wherein said electronic control system is configured to control at least one of a total volume or a flow rate of said intravenous fluid to be injected into said acidotic patient'"'"'s blood based on at least a measured pH of said acidotic patient'"'"'s blood and based on a composition of said at least one supply fluid. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
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17. An intravenous solution for treating acidosis, comprising:
- sodium bicarbonate; and
at least one of disodium carbonate, sodium hydroxide, and tris(hydroxymethyl)aminomethane dissolved in an aqueous solution,wherein said intravenous solution has a pH of at least 10 and a total concentration of osmolites within a near isotonic range. - View Dependent Claims (18, 19)
- sodium bicarbonate; and
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20. A method of treating acidosis, comprising:
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providing an intravenous solution for treating acidosis; and administering said intravenous solution intravenously to an acidotic patient, wherein said intravenous solution has a pH of at least 10 and a total concentration of osmolites within a near isotonic range. - View Dependent Claims (21, 22, 24, 25, 26)
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23. A method of treating acidosis according to claim 23, wherein said intravenous solution consists essentially of said disodium carbonate and sodium bicarbonate dissolved in said aqueous solution.
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27. An intravenous dispersion for treating acidosis, comprising:
a liquid; and a plurality of particles dispersed in said liquid, wherein each particle of said plurality of particles has a maximum outer dimension of less than about 2 micrometers such that said particles can pass unhindered through capillary blood vessels of an acidotic patient being treated, wherein each of said plurality of particles comprises at least one of a shell and a matrix material that dissolves at a predetermined rate within said acidotic patient'"'"'s blood stream, and wherein each of said plurality of particles comprises a pH-influencing material that mixes in said acidotic patient'"'"'s blood stream at a controlled rate while said at least one of said shell and said matrix material dissolves. - View Dependent Claims (28)
Specification