THREE-DIMENSIONAL METAL ION SENSOR ARRAYS ON PRINTED CIRCUIT BOARDS

• US 20150198557A1
• Filed: 03/24/2015
• Published: 07/16/2015
• Est. Priority Date: 08/14/2008
• Status: Abandoned Application

• Current Assignee: Charles Stark Draper Laboratory Incorporated
• Original Assignee: Charles Stark Draper Laboratory Incorporated
• Inventors: Bickford, James A., Williams, John R., Harjes, Daniel I., Reiter, Andrew
• Application Number:
  US14/667,167
• Publication Number:
  US 20150198557A1
• Time in Patent Office: Days
• US Class Current: 1/1
• CPC Class Codes: G01N 27/333 Ion-selective electrodes or membranes glass electrodes G01N27/36
• CPC Class Codes: G01N 27/3335 the membrane containing at least one organic component G01N27/3271 takes precedence; aspects concerning the enzyme reagent in enzyme electrodes C12Q1/001
• CPC Class Codes: Y10T 156/10 Methods of surface bonding and/or assembly therefor

Abstract

An electronic device includes a substrate and a plurality of sensors. Each sensor is disposed in a well over the substrate and includes a working electrode, an inner filling solution disposed thereover, and an ion-selective membrane. The working electrode is in contact with the substrate and the ion-selective membrane is disposed over the inner filling solution and substantially seals the well.

Claims

1. An electronic device, comprising:

a) a substrate; and

b) a plurality of sensors, each disposed within a well over the substrate and comprising;

i) a working electrode in contact with the substrate;

ii) an inner filling solution disposed over the working electrode; and

iii) an ion-selective membrane disposed over the inner filling solution and substantially sealing the well.

2. The electronic device of claim 1, further comprising a silver chloride coating on the working electrode.

3. The electronic device of claim 1, wherein the inner filling solution comprises or consists essentially of a hydrogel.

4. The electronic device of claim 1, wherein the ion-selective membrane comprises polyvinyl chloride.

5. The electronic device of claim 1, further comprising:

c) a second plurality of sensors, each disposed within a well under the substrate and comprising;

i) a working electrode in contact with the substrate;

ii) an inner filling solution disposed over the working electrode; and

iii) an ion-selective membrane disposed over the inner filling solution and substantially sealing the well.

6. The electronic device of claim 1, further comprising a cover disposed over a sub-array of the plurality of sensors, the cover comprising or consisting essentially of solder or a shape-memory alloy.

7. The electronic device of claim 1, further comprising, electrically connected to at least one sensor, at least one of an amplifier, a conditioner, a microprocessor, a memory device, a power source, or a transmitter.

8. The electronic device of claim 1, wherein each well is disposed within a plate disposed over and in direct contact with the substrate.

9. The electronic device of claim 1, wherein each well comprises a non-vertical sidewall.

10. The electronic device of claim 1, wherein the substrate comprises one of a printed circuit board or a ground plane.

11. The electronic device of claim 1, wherein the inner filling solution comprises a liquid i) having a boiling point higher than 100°

C. and ii) capable of conducting ions.

12. The electronic device of claim 1, wherein a first sensor further comprises an ion-conductive filter disposed over the ion-selective membrane.

13. The electronic device of claim 1, further comprising a micro-fluidic front end for delivering a sample solution to the plurality of sensors.

14. The electronic device of claim 13, wherein the micro-fluidic front end comprises a micro-fluidic channel for temporally separating particles of different mass in the sample solution.

15. The electronic device of claim 1, wherein the plurality of sensors is arranged in a two-dimensional array.

16. The electronic device of claim 15, wherein the two-dimensional array temporally separates particles of different mass in a sample solution.

17. The electronic device of claim 1, wherein the plurality of sensors is arranged in a three-dimensional array.