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MASS-SPECTROMETER SYSTEMS AND METHODS

  • US 20150198570A1
  • Filed: 01/09/2015
  • Published: 07/16/2015
  • Est. Priority Date: 01/10/2014
  • Status: Active Grant
First Claim
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1. A system for determining the concentration of an analyte of interest in a bodily fluid, the system comprising:

  • a fluid pumping system comprising at least one positive pressure pump and at least one valve for directing fluid flow;

    a sample preparation portion comprising a disposable cartridge having a sample introduction port, a filtration region, a chromatography region, and an outlet;

    a sample analysis portion comprising a mass spectrometer, wherein the mass spectrometer produces a spectra for the analyte of interest in a sample of a bodily fluid, and at least one of a plurality of isotopes of the analyte of interest or a plurality of derivatized samples of the analyte of interest added to the sample in a single spectral measurement; and

    at least one processor having operational thereon computer instructions for at least controlling operation of the system, determining a concentration of the analyte contained in the bodily fluid sample, and reporting the at least one analyte concentration.

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