GEOGRAPHIC ATROPHY IDENTIFICATION AND MEASUREMENT
First Claim
1. A method of processing acquired ophthalmic image data comprising:
- providing an imaging signal produced by an imaging device capable of penetrating beyond the retinal pigment epithelium (RPE) of a subject'"'"'s eye;
detecting intensities of the imaging signal as the imaging signal is backscattered by each of a plurality of tissue layers in the subject'"'"'s eye for a plurality of axial scans;
determining a ratio of the intensities of the backscattered imaging signals, the ratio being the intensity of the backscattered imaging signal of at least a portion of a retinal layer with respect to the intensity of the backscattered imaging signal of at least a portion of a sub-RPE layer for each of the plurality of axial scans; and
determining a representative value for each of the plurality of axial scans based at least in part on the determined ratio for the corresponding axial scan.
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Accused Products
Abstract
Geographic atrophy of the eye can be detected and measured by imaging the eye at a depth greater than the retinal pigment epithelium (RPE) at a plurality of locations of the eye, for example, using optical coherence tomography (OCT); determining a ratio of the intensities of imaging signals of a retinal layer(s) with respect to the intensity of imaging signals of a sub-RPE layer(s) at each location; determining representative values based at least in part on the determined ratios; generating a map of the representative values; and identifying diseased areas from the map. Contours and binary maps may be generated based on the identified diseased areas. The size and shape of the identified areas may be analyzed and monitored over a period of time.
21 Citations
27 Claims
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1. A method of processing acquired ophthalmic image data comprising:
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providing an imaging signal produced by an imaging device capable of penetrating beyond the retinal pigment epithelium (RPE) of a subject'"'"'s eye; detecting intensities of the imaging signal as the imaging signal is backscattered by each of a plurality of tissue layers in the subject'"'"'s eye for a plurality of axial scans; determining a ratio of the intensities of the backscattered imaging signals, the ratio being the intensity of the backscattered imaging signal of at least a portion of a retinal layer with respect to the intensity of the backscattered imaging signal of at least a portion of a sub-RPE layer for each of the plurality of axial scans; and determining a representative value for each of the plurality of axial scans based at least in part on the determined ratio for the corresponding axial scan. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A method of processing acquired ophthalmic image data comprising:
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providing an imaging signal produced by an imaging device capable of penetrating beyond the choroid/sclera interface of a subject'"'"'s eye; detecting intensities of the imaging signal as the imaging signal is backscattered by each of a plurality of tissue layers in the subject'"'"'s eye for a plurality of axial scans; determining a ratio of the intensities of the backscattered imaging signals for each of the plurality of axial scans, the ratio being the intensity of a first portion of the backscattered imaging signal with respect to the intensity of a second portion of the backscattered imaging; and determining a representative value of each of the plurality of axial scans based at least in part on the determined ratio for the corresponding axial scan. - View Dependent Claims (13, 14, 15, 16, 17, 18, 19, 20)
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21. A method of processing acquired ophthalmic image data comprising:
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providing an imaging signal produced by a imaging device, the imaging signal having a center wavelength of at least 1 μ
m or being a polarization-sensitive optical coherence tomography (PS-OCT) signal;detecting intensities of the imaging signal as the imaging signal is backscattered by each of a plurality of tissue layers in a subject'"'"'s eye for a plurality of axial scans; determining a ratio of the intensities of the backscattered imaging signals for each of the plurality of axial scans, the ratio being the intensity of a first portion of the backscattered imaging signal with respect to the intensity of a second portion of the backscattered imaging; identifying diseased areas of the subject'"'"'s eye based at least in part on the determined ratio. - View Dependent Claims (22, 23, 24, 25, 26, 27)
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Specification