NON-INVASIVE HEALTH INDICATOR MONITORING SYSTEM AND USING METHOD THEREOF

• US 20150201837A1
• Filed: 11/11/2014
• Published: 07/23/2015
• Est. Priority Date: 01/20/2014
• Status: Active Grant

• Current Assignee: Korea Advanced Institute of Science and Technology
• Original Assignee: Korea Advanced Institute of Science and Technology
• Inventors: SONG, Yong Won, CHOI, Ji Won, CHEONG, Byung Ki, KIM, Jin Seok, JANG, Ho Seong, LEE, Su Youn, LEE, Ji Yeon, LIM, Jung Ah, YI, Hyun Jung
• Granted Patent: US 10,292,586 B2
• Time in Patent Office: Days
• US Class Current: 1/1
• CPC Class Codes: A61B 5/0002 Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network A61B5/07 takes precedence; transmission systems for measured values G08C; transmission H04B; transmission of digital information H04L; wireless communication networks H04W
• CPC Class Codes: A61B 5/14507 specially adapted for measuring characteristics of body fluids other than blood devices for taking samples of body liquids A61B10/0045
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/1486 using enzyme electrodes, e.g. with immobilised oxidase
• CPC Class Codes: A61B 5/6821 Eye
• CPC Class Codes: H01M 10/00 Secondary cells; Manufacture thereof
• CPC Class Codes: H01M 10/0525 Rocking-chair batteries, i.e. batteries with lithium insertion or intercalation in both electrodes; Lithium-ion batteries
• CPC Class Codes: H01M 10/058 Construction or manufacture
• CPC Class Codes: H01M 2220/30 Batteries in portable systems, e.g. mobile phone, laptop
• CPC Class Codes: H01M 50/202 Casings or frames around the primary casing of a single cell or a single battery
• CPC Class Codes: H01M 50/247 specially adapted for portable devices, e.g. mobile phones, computers, hand tools or pacemakers
• CPC Class Codes: Y02E 60/10 Energy storage using batteries

Abstract

The present invention relates to a non-invasive health indicator monitoring system including a sensing module, an electric power storage module, and a circuit module to collect health indicator information by contacting with a subject. In addition, the present invention also relates to a method for monitoring health indicator continuously by using the health indicator monitoring system.

Claims

1. A noninvasive health indicator monitoring system collecting at least one health indicator information in contact with a subject, comprising

a sensing module to collect health indicator information obtained from at least one health indicator marker;

a power storage module located on a support board to provide electric power to the sensing module continuously; and

a circuit module connected with the sensing module and the power storage module respectively to drive the sensing module, save or transmit the collected health indicator information, and control power supply of the system.

2. The noninvasive health indicator monitoring system according to claim 1, wherein the circuit module comprises a sensor driving part to drive the sensing module, a data control part to control the health indicator information, a transmission part to deliver the health indicator information to external devices or all of them.

3. The noninvasive health indicator monitoring system according to claim 1, further comprising a power generation module, wherein the power generation module is connected with the power storage module in which the generated power is stored.

4. The noninvasive health indicator monitoring system according to claim 1, wherein the system comprises multilayer structure comprising a first, a second, and a third layer;

the first layer is in contact with the subject;

the second layer is located on the first layer and comprises the power storage module and the circuit module; and

the third layer is located on the second layer and comprises the sensing module,

wherein the multilayer structure is at least partially transparent and generally flexible;

has a shape of contact lens; and

is located between the eyeball and the eyelid in a driving mode.

5. The noninvasive health indicator monitoring system according to claim 4, wherein the third layer further comprises a power generation module.

6. The noninvasive health indicator monitoring system according to claim 5,

wherein the power generation module comprises one selected from the group consisting of thin film type solar cell part, a piezoelectric nanogenerator part, a triboelectric nanogenerator part, and the combinations thereof,

wherein the thin film type solar cell part comprises a quantum dot (QD) photoelectronic device, photon cut nanoparticle or all of them and the quantum dot (QD) comprises one selected from the group consisting of SnS, CuInSe, CuS, FeS and the combinations thereof,

wherein the piezoelectric nanogenerator part comprises a nano structure of lead-free piezoelectric nano wire comprising one selected from the group consisting of ZnO, NKN, BaTiO3 and the combinations thereof, and

wherein the triboelectric nanogenerator part comprises one nano structure selected from the group consisting of PDMS, polymeric nanostructure and the combinations thereof.

7. The noninvasive health indicator monitoring system according to claim 4, wherein the health indicator information is blood glucose level and the health indicator marker is tear glucose level.

8. The noninvasive health indicator monitoring system according to claim 4, wherein the health indicator marker is one selected from the group consisting of glucose level, glycated albumin level, fructosamine level, 1,5-anhydroglucytol level, uric acid level, lactic acid level, pyruvate level, ascorbate level, and the combinations thereof.

9. The noninvasive health indicator monitoring system according to claim 4, wherein the sensing module, the power generation module, the power storage module and the circuit module are connected together though interconnect and the interconnect is biocompatible, flexible and transparent interconnect or micro interconnect having the line width of no more than 50 μ

m.

10. The noninvasive health indicator monitoring system according to claim 9, wherein the interconnect comprises one selected from the group consisting of conductive nanoparticle, nanosized metal structure, oxide semiconductor, conductive polymer, carbon nanotube, graphene and the combinations thereof.

11. The noninvasive health indicator monitoring system according to claim 4, wherein the power storage module comprises a laminated flexible thin film battery or a capacitor and the laminated flexible thin film battery comprises a grid structure having transparent or no more than 50 μ

m of micro line width.

12. The noninvasive health indicator monitoring system according to claim 11, wherein the laminated flexible thin film battery is a transparent laminated flexible thin film battery comprising transparent cathode material, transparent electrolyte, and transparent anode material.

13. The noninvasive health indicator monitoring system according to claim 4,

wherein the sensing module comprises a filter part to filter proteins and a sensor part to quantify the health indicator marker from a body fluid filtered through the filter part;

the circuit module connected with the sensor part obtains the health indicator information and saves and transmits the obtained health indicator information; and

the sensor part may comprise a multi-sensor array comprising at least two unit sensors.

14. The noninvasive health indicator monitoring system according to claim 4, wherein the system has a thickness of no more than 300 μ

m;

comprises a light transmission part comprising micro interconnect which is transparent or has a thickness of no more than eye resolution on the center of the contact lens shaped multilayer structure; and

the light transmission part has a diameter of 0.5˜

2 mm.

15. The noninvasive health indicator monitoring system according to claim 13,

wherein the sensor part comprises an enzymatic amperometric sensor, a non-enzymatic amperometric sensor or a hybrid sensor comprising both of the enzymatic amperometric sensor and the non-enzymatic amperometric sensor,

wherein the enzymatic amperometric sensor quantifies glucose from enzymatic decomposition of glucose by glucose oxidase, and

wherein the non-enzymatic amperometric sensor quantify glucose by using electrocatalytic activity of the crystal face of metal nanoparticles involved in the sensor.

16. The noninvasive health indicator monitoring system according to claim 15, wherein the metal nanoparticle comprises one selected from the group consisting of Au, Pt and the combination thereof.

17. The noninvasive health indicator monitoring system according to claim 4, wherein the supporting substrate in the multilayer structure comprises a soft hydrogel material, the multilayer structure further comprises a protective layer covering whole of the multilayer structure, and the protective layer further comprises one selected from the group consisting of HEMA, soft hydrogel, silicone acrylate, fluoro-silicone acrylate and the combinations thereof.

18. The noninvasive health indicator monitoring system according to claim 1, wherein the power storage module is supplied with energy in wireless charging manner.

19. The noninvasive health indicator monitoring system according to claim 18, wherein the wireless charging manner is magnetic resonance.

20. A method for noninvasively monitoring health indicator using a noninvasive health indicator monitoring system, comprising:

collecting health indicator information obtained from at least one health indicator marker; and

delivering the collected health indicator information to external devices,

wherein the noninvasive health indicator monitoring system collects at least one health indicator information in contact with a subject; and

comprises

a sensing module to collect health indicator information obtained from at least one health indicator marker;

a power storage module located on a support board to provide electric power to the sensing module continuously; and

a circuit module connected with the sensing module and the power storage module respectively to drive the sensing module, save or transmit the collected health indicator information, and control power supply of the system.

21. The method for noninvasively monitoring health indicator according to claim 20, wherein the circuit module comprises a sensor driving part to drive the sensing module, a data control part to control the health indicator information, a transmission part to deliver the health indicator information to external devices or all of them.

22. The method for noninvasively monitoring health indicator according to claim 20, further comprising a power generation module, wherein the power generation module is connected with the power storage module in which the generated power is stored.

23. The method for noninvasively monitoring health indicator according to claim 20, wherein the system comprises multilayer structure comprising a first, a second, and a third layer;

the first layer is in contact with the subject;

the second layer is located on the first layer and comprises the power storage module and the circuit module; and

the third layer is located on the second layer and comprises the sensing module,

wherein the multilayer structure is at least partially transparent and generally flexible;

has a shape of contact lens; and

is located between the eyeball and the eyelid in a driving mode.

24. The method for noninvasively monitoring health indicator according to claim 23, wherein the third layer further comprises a power generation module.

25. The method for noninvasively monitoring health indicator according to claim 24,

wherein the power generation module comprises one selected from the group consisting of thin film type solar cell part, a piezoelectric nanogenerator part, a triboelectric nanogenerator part, and the combinations thereof,

wherein the thin film type solar cell part comprises a quantum dot (QD) photoelectronic device, photon cut nanoparticle or all of them and the quantum dot (QD) comprises one selected from the group consisting of SnS, CuInSe, CuS, FeS and the combinations thereof,

wherein the piezoelectric nanogenerator part comprises a nano structure of lead-free piezoelectric nano wire comprising one selected from the group consisting of ZnO, NKN, BaTiO3 and the combinations thereof, and

wherein the triboelectric nanogenerator part comprises one nano structure selected from the group consisting of PDMS, polymeric nanostructure and the combinations thereof.

26. The method for noninvasively monitoring health indicator according to claim 23, wherein the health indicator information is blood glucose level and the health indicator marker is tear glucose level.

27. The method for noninvasively monitoring health indicator according to claim 23, wherein the health indicator marker is one selected from the group consisting of glucose level, glycated albumin level, fructosamine level, 1,5-anhydroglucytol level, uric acid level, lactic acid level, pyruvate level, ascorbate level, and the combinations thereof.

28. The method for noninvasively monitoring health indicator according to claim 23, wherein the sensing module, the power generation module, the power storage module and the circuit module are connected together though interconnect and the interconnect is biocompatible, flexible and transparent interconnect or micro interconnect having the line width of no more than 50 μ

m.

29. The method for noninvasively monitoring health indicator according to claim 28, wherein the interconnect comprises one selected from the group consisting of conductive nanoparticle, nanosized metal structure, oxide semiconductor, conductive polymer, carbon nanotube, graphene and the combinations thereof.

30. The method for noninvasively monitoring health indicator according to claim 23, wherein the power storage module comprises a laminated flexible thin film battery or a capacitor and the laminated flexible thin film battery comprises a grid structure having transparent or no more than 50 μ

m of micro line width.

31. The method for noninvasively monitoring health indicator according to claim 30, wherein the laminated flexible thin film battery is a transparent laminated flexible thin film battery comprising transparent cathode material, transparent electrolyte, and transparent anode material.

32. The method for noninvasively monitoring health indicator according to claim 23,

wherein the sensing module comprises a filter part to filter proteins and a sensor part to quantify the health indicator marker from a body fluid filtered through the filter part;

the circuit module connected with the sensor part obtains the health indicator information and saves and transmits the obtained health indicator information; and

the sensor part may comprise a multi-sensor array comprising at least two unit sensors.

33. The method for noninvasively monitoring health indicator according to claim 23, wherein the system has a thickness of no more than 300 μ

m;

comprises a light transmission part comprising micro interconnect which is transparent or has a thickness of no more than eye resolution on the center of the contact lens shaped multilayer structure; and

the light transmission part has a diameter of 0.5˜

2 mm.

34. The method for noninvasively monitoring health indicator according to claim 32,

wherein the sensor part comprises an enzymatic amperometric sensor, a non-enzymatic amperometric sensor or a hybrid sensor comprising both of the enzymatic amperometric sensor and the non-enzymatic amperometric sensor,

wherein the enzymatic amperometric sensor quantifies glucose from enzymatic decomposition of glucose by glucose oxidase, and

wherein the non-enzymatic amperometric sensor quantify glucose by using electrocatalytic activity of the crystal face of metal nanoparticles involved in the sensor.

35. The method for noninvasively monitoring health indicator according to claim 34, wherein the metal nanoparticle comprises one selected from the group consisting of Au, Pt and the combination thereof.

36. The method for noninvasively monitoring health indicator according to claim 23, wherein the supporting substrate in the multilayer structure comprises a soft hydrogel material, the multilayer structure further comprises a protective layer covering whole of the multilayer structure, and the protective layer further comprises one selected from the group consisting of HEMA, soft hydrogel, silicone acrylate, fluoro-silicone acrylate and the combinations thereof.

37. The method for noninvasively monitoring health indicator according to claim 20 which continuously obtains, saves and transmits quantitative information of glucose level from tear.

38. The method for noninvasively monitoring health indicator according to claim 20, wherein the power storage module is supplied with energy in wireless charging manner.

39. The method for noninvasively monitoring health indicator according to claim 37, wherein the wireless charging manner is magnetic resonance.