PORTABLE CRYOGENIC WORKSTATION

• US 20150204598A1
• Filed: 01/20/2015
• Published: 07/23/2015
• Est. Priority Date: 01/20/2014
• Status: Active Application

• Current Assignee: Brooks Automation Incorporated (Azenta, Inc.)
• Original Assignee: Brooks Automation Incorporated (Azenta, Inc.)
• Inventors: Affleck, Rhett L., Bonora, Anthony C., Neeper, Robert K., Croquette, Etienne P.
• Application Number:
  US14/600,751
• Publication Number:
  US 20150204598A1
• Time in Patent Office: Days
• US Class Current: 1/1
• CPC Class Codes: A01N 1/0257 Stationary or portable vessels generating cryogenic temperatures
• CPC Class Codes: B65B 3/003 Filling medical containers such as ampoules, vials, syringes or the like
• CPC Class Codes: F25D 23/02 Doors; Covers F25D23/08 takes precedence locks or fastenings E05B65/0042
• CPC Class Codes: F25D 29/001 for cryogenic fluid systems
• CPC Class Codes: F25D 3/107 portable, i.e. adapted to be carried personally
• CPC Class Codes: G01F 23/22 by measuring physical variables, other than linear dimensions, pressure or weight, dependent on the level to be measured, e.g. by difference of heat transfer of steam or water involving the use of floats G01F23/30
• CPC Class Codes: G01N 2035/00435 Refrigerated reagent storage
• CPC Class Codes: G01N 2035/00445 Other cooling arrangements
• CPC Class Codes: G01N 35/0099 comprising robots or similar manipulators robots per se B25J
• CPC Class Codes: G05B 15/02 electric
• CPC Class Codes: G05D 1/021 specially adapted to land vehicles

Abstract

A portable cryogenic workstation includes a housing having an internal cavity configured to hold one or more samples, a lid for sealing the internal cavity such that the portable cryogenic workstation is configured for transporting samples between about room temperature environments to about ultra-cold environments, at least one automation interface disposed on one or more of the housing and lid and configured for engagement with automated handling equipment, and a process data capture unit coupled to the housing and configured to capture process or ephemeral data corresponding to a predetermined processing characteristic(s) of at least one of the samples coincident with presence inside the portable cryogenic workstation.

Claims

1. A portable cryogenic workstation comprising:

a housing having an internal cavity configured to hold one or more samples;

a lid for sealing the internal cavity such that the portable cryogenic workstation is configured for transporting samples between about room temperature environments to about ultra-cold environments;

at least one automation interface disposed on one or more of the housing and lid and configured for engagement with automated handling equipment; and

a process data capture unit coupled to the housing and configured to capture process or ephemeral data corresponding to a predetermined processing characteristic(s) of at least one of the samples coincident with presence inside the portable cryogenic workstation.

2. The portable cryogenic workstation of claim 1, wherein the process data capture unit is configured so that the process or ephemeral data captured define process history and enables analysis of the predetermined processing characteristic(s) of at least one of the samples.

3. The portable cryogenic workstation of claim 1, wherein the process data capture unit is communicably coupled to a controller and at least one sensor connected to the controller where the at least one sensor is configured to provide one or more of sample location data, sample identification data, temperature data and a physical state of the lid relative to the housing.

4. The portable cryogenic workstation of claim 1, wherein the portable cryogenic workstation includes a consumable media level detector.

5. A portable cryogenic workstation comprising:

a housing having an opening forming an interior cavity configured to hold one or more racks of cryogenic samples, a workstation interface and a lid interface disposed around a periphery of the opening; and

a lid configured to close the opening and substantially seal the interior cavity, the lid having a housing interface configured to engage the lid interface so that the lid effects sealing of the interior cavity and to disengage the lid interface and unseal the interior cavity with a single axis movement of the lid relative to the housing;

wherein the housing is configured to engage a closable input/output port of a workstation.

6. The portable cryogenic workstation of claim 5, wherein engagement of the housing with the input/output port effects a seal between the input/output port and the workstation interface so that when the lid is opened the interior cavity is in sealed communication with an interior of the workstation.

7. The portable cryogenic workstation of claim 5, wherein the housing is configured to effect a seal between the input/output port and the workstation interface with the lid separated from the housing.

8. The portable cryogenic workstation of claim 6, wherein the housing is configured to effect the seal between the input/output port and the workstation interface with the lid engaged to the housing and separated from the housing.

9. The portable cryogenic workstation of claim 6, wherein the seal between the input/output port and the portable cryogenic workstation seals the interior of a loading module of the workstation from an external atmosphere.

10. The portable cryogenic workstation of claim 6, wherein the seal between the input/output port and the portable cryogenic workstation seals the interior of the portable cryogenic workstation from an outside atmosphere.

11. The portable cryogenic workstation of claim 6, wherein the housing is configured to effect the seal between the input/output port and the workstation interface with the lid engaged to the housing.

12. The portable cryogenic workstation of claim 5, wherein the portable cryogenic workstation includes a consumable media level detector.

13. The portable cryogenic workstation of claim 5, wherein the portable cryogenic workstation is configured to record process data related to predetermined characteristics of one or more of the samples, the housing and the lid.

14. The portable cryogenic workstation of claim 5, further comprising a controller, a memory and at least one sensor, the memory and the at least one sensor each being connected to the controller, the controller being configured to effect a recordation of process tracking data in the memory based on signals from the at least one sensor.

15. The portable cryogenic workstation of claim 12, wherein the controller is configured to effect the recordation of process tracking data in response to a triggering event.

16. The portable cryogenic workstation of claim 12, wherein the controller is configured to allow analysis of the process tracking data.

17. The portable cryogenic workstation of claim 12, wherein the controller, memory and at least one sensor are integral with the one or more of the housing and the lid.

18. The portable cryogenic workstation of claim 5, wherein the portable cryogenic workstation effects a thermal block to heat load entry into the cryogenic portion of the workstation through the input/output port.

19. A cryogenic workstation comprising:

a storage module having an ultra-cold storage vault configured to store racks of cryogenic samples;

a loading module disposed external to the storage module and including a load port and a closeable opening, the closeable opening communicably connecting the loading module to the storage module where the cryogenic samples are transferred between the storage module and the loading module through the closeable opening, and the load port including a closeable input/output port; and

a portable cryogenic workstation module configured to engage the closeable input/output port.

20. The cryogenic workstation of claim 19, wherein engagement of the portable cryogenic workstation with the closeable input/output port effects a seal between the load port and the portable cryogenic workstation so that when the load port is opened an interior of the loading module is in sealed communication with an interior of the portable cryogenic workstation.

21. The cryogenic workstation of claim 20, wherein the seal between the load port and the portable cryogenic workstation module seals the interior of the loading module from an external atmosphere.

22. The cryogenic workstation of claim 20, wherein the seal between the load port and the portable cryogenic workstation seals the interior of the portable cryogenic workstation module from an outside atmosphere.

23. The cryogenic workstation of claim 19, wherein the portable cryogenic workstation module includes a housing configured to close the closeable input/output port when the load port is opened.

24. The cryogenic workstation of claim 19, further comprising an interface device for a portable cryogenic workstation, the interface device includes a housing forming an internal chamber and at least one portable cryogenic workstation interface disposed at least partly within the internal chamber, the at least one portable cryogenic workstation interface being configured to access an interior of the portable cryogenic workstation and load and unload samples from the interior, where the portable cryogenic workstation is configured for porting in and out of the interface device housing while maintaining a cryogenic atmosphere within the portable cryogenic workstation.

25. The cryogenic workstation of claim 24, wherein the interface device is configured to isolate a human operator from the interior.

26. The cryogenic workstation of claim 24, wherein the interface device is configured as a stand alone device for bench top placement.

27. The cryogenic workstation of claim 24, wherein the interface device may be integrated with an automated material handling system or refrigerant replenishment station.

28. The cryogenic workstation of claim 24, wherein the at least one portable cryogenic workstation interface is configured for manual operation.

29. The cryogenic workstation of claim 24, wherein the at least one portable cryogenic workstation interface is configured for automated operation.

30. The cryogenic workstation of claim 24, wherein the interface device includes a display and processor for communicating process or ephemeral data to and from the portable cryogenic workstation.

31. The cryogenic workstation of claim 19, wherein the at least one portable cryogenic workstation interface device includes one or more kinematic locating features for deterministically locating the portable cryogenic workstation with respect to a predetermined reference frame of the interface device.

32. An automated material handling system for transporting portable cryogenic workstations comprising:

a first cryogenic workstation location and a second cryogenic workstation location that is different than the first cryogenic workstation location;

an automated transport configured to travel between the first and second cryogenic workstation locations, the automated transport having an effector for transporting at least one portable cryogenic workstation; and

the at least one portable cryogenic workstation includes a housing configured to hold a cryogenic environment within an openable cavity of the housing through a removable closure, the housing including a first interface configured to engage the automated transport and a second interface configured to deterministically position the at least one portable cryogenic workstation at an interface station at one of the first and second cryogenic workstation locations; and

an automated workpiece transport configured to automatically pick or place at least one workpiece within the at least one portable cryogenic workstation.

33. The automated material handling system of claim 32, wherein the automated workpiece transport comprises a robotic arm with an end effector configured for picking workpieces.

34. The automated material handling system of claim 32, wherein the automated transport comprises an overhead transport system.

35. The automated material handling system of claim 32, wherein the automated transport comprises an automated guided vehicle.

36. The automated material handling system of claim 32, wherein the automated transport comprises a conveyor.

37. The automated material handling system of claim 32, wherein the automated transport comprises two different types of transport configured to transfer the at least one portable cryogenic workstation between the two different types of transports.

38. An automated material handling system comprising:

a portable cryogenic workstation transport unit having an effector configured to engage and transport a portable cryogenic workstation, where the portable cryogenic workstation includes a housing forming an internal cavity and a lid configured to substantially seal the internal cavity; and

an automated sample handling system configured to transport samples to and from the internal cavity, at least one of the automated sample handling system and the transport unit having a lid removal system configured to engage kinematic coupling features of the lid for deterministically locating the lid relative to the lid removal system.

39. The automated material handling system of claim 38, wherein the effector is configured to engage kinematic coupling features of the housing to deterministically locate the housing relative to the automated sample handling system.

40. A consumable media replenishment station comprising:

a fill port configured to communicate a consumable media to an interior of a portable cryogenic workstation; and

kinematic locating features configured to interface with the portable cryogenic workstation for deterministically locating the portable cryogenic workstation relative to the fill port.

41. The consumable media replenishment station of claim 40, wherein the consumable media replenishment station is disposed at a load port of an automated cryogenic sample handling station.

42. The consumable media replenishment station of claim 40, wherein the consumable media replenishment station is a stand alone replenishment station.

43. The consumable media replenishment station of claim 40, wherein the fill port comprises a manifold configured to interface with two or more portable cryogenic workstations.