Metal Oxide Scaffolds

• US 20150209471A1
• Filed: 01/30/2015
• Published: 07/30/2015
• Est. Priority Date: 12/21/2006
• Status: Abandoned Application

• Current Assignee: Corticalis AS
• Original Assignee: Corticalis AS
• Inventors: Haugen, Havard J., Ellingsen, Jan Eirik, Lyngstadaas, Stale Petter
• Application Number:
  US14/610,394
• Publication Number:
  US 20150209471A1
• Time in Patent Office: Days
• US Class Current: 1/1
• CPC Class Codes: A61F 2/28 Bones joints A61F2/30
• CPC Class Codes: A61F 2002/2835 Bone graft implants for filling a bony defect or an endoprosthesis cavity, e.g. by synthetic material or biological material
• CPC Class Codes: A61F 2002/3092 having an open-celled or open-pored structure
• CPC Class Codes: A61F 2310/00185 based on metal oxides
• CPC Class Codes: A61L 2400/18 Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment
• CPC Class Codes: A61L 2430/02 for reconstruction of bones; weight-bearing implants
• CPC Class Codes: A61L 27/025 Other specific inorganic materials not covered by A61L27/04 - A61L27/12
• CPC Class Codes: A61L 27/50 Materials characterised by their function or physical properties , e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
• CPC Class Codes: A61L 27/56 Porous materials, e.g. foams or sponges
• CPC Class Codes: B29C 39/003 characterised by the choice of material
• CPC Class Codes: B29L 2031/7532 Artificial members, protheses

Abstract

The present invention relates to a metal oxide scaffold comprising titanium oxide. The scaffolds of the invention are useful for implantation into a subject for tissue regeneration and for providing a framework for cell growth and stabilization to the regenerating tissue. The invention also relates to methods for producing such metal oxide scaffolds and their uses.

Claims

1. A metal oxide scaffold comprising titanium oxide, said scaffold having a compression strength of about 0.1-150 MPa, wherein the titanium oxide constitutes 40-100 wt % and wherein the titanium oxide is formed from titanium oxide particles comprising less than about 10 ppm of contaminations of secondary and/or tertiary phosphates on the surface of the titanium oxide particles.

2. A metal oxide scaffold according to claim 1, wherein said compression strength is about 5-15 MPa.

3. A metal oxide scaffold according to claim 1 having a porosity of about 40-99% preferably 70-90%.

4. A metal oxide scaffold according to claim 1 having a pore size of about 10-3000 μ

m, preferably about 20-2000 μ

m, more preferably about 30-1500 μ

m and even more preferably about 30-700 μ

m.

5. A metal oxide scaffold according to claim 1 having a fractal dimension strut of about 2.0-3.0, preferably about 2.2-2.3.

6. A metal oxide scaffold according to claim 1 having an inner strut volume of about 0.001-3.0 μ

m³, preferably about 0.8-1.2 μ

m³.

7. A metal oxide scaffold according to claim 1, wherein said pore are interconnective or partially interconnective.

8. A metal oxide scaffold according to claim 1, further comprising a least one oxide of Zr, Hf, V, Nb, Ta and/or Al.

9. A metal oxide scaffold according to claim 1 wherein the titanium oxide constitutes 40-100 wt %, preferably 60-90 wt %, of the metal oxides present in the scaffold.

10. A metal oxide scaffold according to claim 1 comprising at least one surface which is at least partially covered with fluoride and/or fluorine.

11. A metal oxide scaffold according to claim 10, wherein said fluoride is provided in an aqueous solution comprising HF, NaF and/or CaF2, in a gas phase and/or as a vapour.

12. A metal oxide scaffold according to claim 1 wherein the titanium oxide comprises less than about 10 ppm of contaminations of secondary and/or tertiary phosphates.

13. A metal oxide scaffold according to claim 1, wherein the titanium oxide comprises TiO₂.

14. A metal oxide scaffold according to claim 1, wherein said metal oxide comprises one or more titanium oxides selected from TiO₂, Ti₃O, Ti₂O, Ti₃O₂, TiO, Ti₂O₃, or Ti₃O₅.

15. A metal oxide scaffold according to claim 1, wherein the metal oxide consists of one or more oxides of titanium.

16. A metal oxide scaffold claim 15, wherein the oxide of titanium consists of TiO₂.

17. A metal oxide scaffold according to claim 1 for the regeneration, repair, substitution and/or restoration of tissue, such as bone.

18. A medical implant comprising a metal oxide scaffold comprising titanium oxide, said scaffold having a compression strength of about 0.1-150 MPa, wherein the titanium oxide constitutes 40-100 wt % and wherein the titanium oxide is formed from titanium oxide particles comprising less than about 10 ppm of contaminations of secondary and/or tertiary phosphates on the surface of the titanium oxide particles.

19. A slurry for preparing a metal oxide scaffold comprising an aqueous solution of titanium oxide particles, said titanium oxide particles comprising less than about 10 ppm of contaminations of secondary and/or tertiary phosphates on the surface of the titanium oxide particles, wherein the titanium oxide constitutes 40-100 wt % of the titanium oxide particles.

20. (canceled)

21. A method for producing a metal oxide scaffold comprising the steps of

a) preparing a slurry of metal oxide comprising titanium oxide particles, wherein the oxide of titanium particles comprise less than about 10 ppm of contaminations of secondary and/or tertiary phosphates on the surface of the titanium oxide particles, wherein the titanium oxide constitutes 40-100 wt % of the titanium oxide particles,

b) providing the slurry of step a) to a porous polymer structure

c) allowing the slurry of step b) to solidify

d) removing the porous polymer structure from the solidified metal oxide slurry.

22-40. -40. (canceled)