Metal Oxide Scaffolds
First Claim
1. A metal oxide scaffold comprising titanium oxide, said scaffold having a compression strength of about 0.1-150 MPa, wherein the titanium oxide constitutes 40-100 wt % and wherein the titanium oxide is formed from titanium oxide particles comprising less than about 10 ppm of contaminations of secondary and/or tertiary phosphates on the surface of the titanium oxide particles.
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Abstract
The present invention relates to a metal oxide scaffold comprising titanium oxide. The scaffolds of the invention are useful for implantation into a subject for tissue regeneration and for providing a framework for cell growth and stabilization to the regenerating tissue. The invention also relates to methods for producing such metal oxide scaffolds and their uses.
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Citations
22 Claims
- 1. A metal oxide scaffold comprising titanium oxide, said scaffold having a compression strength of about 0.1-150 MPa, wherein the titanium oxide constitutes 40-100 wt % and wherein the titanium oxide is formed from titanium oxide particles comprising less than about 10 ppm of contaminations of secondary and/or tertiary phosphates on the surface of the titanium oxide particles.
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18. A medical implant comprising a metal oxide scaffold comprising titanium oxide, said scaffold having a compression strength of about 0.1-150 MPa, wherein the titanium oxide constitutes 40-100 wt % and wherein the titanium oxide is formed from titanium oxide particles comprising less than about 10 ppm of contaminations of secondary and/or tertiary phosphates on the surface of the titanium oxide particles.
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19. A slurry for preparing a metal oxide scaffold comprising an aqueous solution of titanium oxide particles, said titanium oxide particles comprising less than about 10 ppm of contaminations of secondary and/or tertiary phosphates on the surface of the titanium oxide particles, wherein the titanium oxide constitutes 40-100 wt % of the titanium oxide particles.
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20. (canceled)
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21. A method for producing a metal oxide scaffold comprising the steps of
a) preparing a slurry of metal oxide comprising titanium oxide particles, wherein the oxide of titanium particles comprise less than about 10 ppm of contaminations of secondary and/or tertiary phosphates on the surface of the titanium oxide particles, wherein the titanium oxide constitutes 40-100 wt % of the titanium oxide particles, b) providing the slurry of step a) to a porous polymer structure c) allowing the slurry of step b) to solidify d) removing the porous polymer structure from the solidified metal oxide slurry.
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22-40. -40. (canceled)
Specification