DETECTING CANCER WITH ANTI-CXCL13 AND ANTI-CXCR5 ANTIBODIES
First Claim
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1. A method for detecting the presence of cancer in a subject, comprising:
- detecting the level of expression of one or more cancer marker in a biological sample obtained from said subject; and
comparing the level of expression of said one or more cancer markers in said biological sample to a normal level of expression of said one or more cancer markers,wherein a higher than normal level of expression of said one or more cancer markers in said biological sample is indicative of the presence of cancer in said subject,wherein said normal level of expression of said one or more cancer markers is a predetermined value or is obtained from a control sample of known normal non-cancerous cells of the same origin or type as said biological sample, andwherein said cancer is carcinoma, andwherein said one or more cancer markers comprises CXCL13 or CXCR5 or both CXCL13 and CXCR5.
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Abstract
Methods for diagnosing cancer in a subject are disclosed. The method includes detecting the level of expression of one or more cancer markers in a biological sample obtained from the subject; and comparing the level of expression of the one or more cancer markers in the biological sample to a normal level of expression of the one or more cancer markers. The one or more cancer markers comprises CXCL13 or CXCR5 or both CXCL13 and CXCR5. Also disclosed is a kit for detecting cancer or monitoring cancer progression.
4 Citations
23 Claims
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1. A method for detecting the presence of cancer in a subject, comprising:
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detecting the level of expression of one or more cancer marker in a biological sample obtained from said subject; and comparing the level of expression of said one or more cancer markers in said biological sample to a normal level of expression of said one or more cancer markers, wherein a higher than normal level of expression of said one or more cancer markers in said biological sample is indicative of the presence of cancer in said subject, wherein said normal level of expression of said one or more cancer markers is a predetermined value or is obtained from a control sample of known normal non-cancerous cells of the same origin or type as said biological sample, and wherein said cancer is carcinoma, and wherein said one or more cancer markers comprises CXCL13 or CXCR5 or both CXCL13 and CXCR5. - View Dependent Claims (2, 3, 5, 6, 17)
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4. (canceled)
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7-16. -16. (canceled)
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18. A method for assessing the prognosis of a subject with a cancer, comprising:
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determining the expression level of one or more cancer markers in a biological sample from said subject, and comparing the level of expression of said one or more cancer markers in said biological sample to a control level of expression of said one or more cancer markers, wherein a higher level of expression of said one or more cancer markers in the biological sample relative to said control level indicates that the prognosis of said subject is poor, wherein a lower or similar level of expression of said one or more cancer markers in said biological sample relative to said control level indicates that the prognosis of said subject is good, wherein a poor prognosis indicates that said cancer is of an aggressive or invasive type, wherein said cancer is carcinoma, and wherein said one or more cancer markers comprise CXCL13 or CXCR5 or both CXCL13 and CXCR5. - View Dependent Claims (19)
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20. A method for monitoring the course of cancer treatment in a subject, comprising:
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determining the expression levels of one or more cancer markers in one or more biological samples obtained from said subject during or after said treatment, and comparing the level of expression of said one or more cancer markers in said one or more biological samples to a control level of expression of said one or more cancer markers, wherein said control level of said one or more cancer markers is a pre-treatment level of said one or more cancer markers in said subject or a predetermined reference level, wherein said treatment is deemed efficacious if said one or more cancer markers in said one or more biological samples is similar to or lower than said control level, wherein said cancer is carcinoma, and wherein said one or more cancer markers comprise CXCL13 or CXCR5 or both CXCL13 and CXCR5. - View Dependent Claims (21)
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22. A kit for detecting cancer or monitoring cancer progression, comprising:
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reagents for determining expression of CXCL13 and/or CXCR5 in a biological sample; and
instructions for how to use said reagents,wherein said reagents comprise an anti-CXCL13 antibody, an anti-CXCR5 antibody, or both and wherein said cancer is carcinoma. - View Dependent Claims (23)
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Specification