SYSTEM AND METHOD FOR DELIVERING MODULATED SUB-THRESHOLD THERAPY TO A PATIENT

• US 20150217116A1
• Filed: 01/21/2015
• Published: 08/06/2015
• Est. Priority Date: 02/05/2014
• Status: Active Grant

• Current Assignee: Boston Scientific Neuromodulation Corporation (Boston Scientific Corporation)
• Original Assignee: Boston Scientific Neuromodulation Corporation (Boston Scientific Corporation)
• Inventors: Parramon, Jordi, Hershey, Bradley L., Lee, Dongchul
• Granted Patent: US 9,381,359 B2
• Time in Patent Office: Days
• US Class Current: 1/1
• CPC Class Codes: A61N 1/0551 Spinal or peripheral nerve electrodes
• CPC Class Codes: A61N 1/36071 Pain
• CPC Class Codes: A61N 1/36125 Details of circuitry or electric components
• CPC Class Codes: A61N 1/36132 using patient feedback
• CPC Class Codes: A61N 1/3615 Intensity
• CPC Class Codes: A61N 1/36164 Sub-threshold or non-excitatory signals non-excitatory signals to the heart A61N1/3628
• CPC Class Codes: A61N 1/37247 User interfaces, e.g. input or presentation means

Abstract

A neuromodulation system configured for providing sub-threshold neuromodulation therapy to a patient. The neuromodulation system comprises a neuromodulation lead having at least one electrode configured for being implanted along a spinal cord of a patient, a plurality of electrical terminals configured for being respectively coupled to the at least one electrode, modulation output circuitry configured for delivering sub-threshold modulation energy to active ones of the at least one electrode, and control/processing circuitry configured for selecting a percentage from a plurality of percentages based on a known longitudinal location of the neuromodulation lead relative to the spinal cord, computing an amplitude value as a function of the selected percentage, and controlling the modulation output circuitry to deliver sub-threshold modulation energy to the patient at the computed amplitude value.

Claims

1. A neuromodulation system, comprising:

a neuromodulation lead having at least one electrode configured for being implanted along a spinal cord of a patient;

a plurality of electrical terminals configured for being respectively coupled to the at least one electrode;

modulation output circuitry configured for delivering sub-threshold modulation energy to active ones of the at least one electrode; and

control/processing circuitry configured for selecting a percentage from a plurality of percentages based on a known longitudinal location of the neuromodulation lead relative to the spinal cord, computing an amplitude value as a function of the selected percentage, and controlling the modulation output circuitry to deliver sub-threshold modulation energy to the patient at the computed amplitude value.

2. The neuromodulation system of claim 1, wherein the control/processing circuitry is configured for determining the known longitudinal location of the implanted neuromodulation lead relative to the spinal cord.

3. The neuromodulation system of claim 1, further comprising a user interface configured for receiving user input defining the known longitudinal location of the implanted neuromodulation lead relative to the spinal cord.

4. The neuromodulation system of claim 1, wherein the control/processing circuitry is configured for computing the amplitude value as a function of the percentage and a perception threshold of the patient.

5. The neuromodulation system of claim 4, wherein the selected percentage is a first percentage if the longitudinal location is in a first region of the spinal cord, and the selected percentage is a second percentage if the longitudinal location is in a second region of the spinal cord, wherein the second percentage is higher than the first percentage, and the second region of the spinal cord is caudal to the first region of the spinal cord.

6. The neuromodulation system of claim 4, wherein the selected percentage is a first percentage if the longitudinal location is in a cervical region of the spinal cord, the selected percentage is a second percentage if the longitudinal location is in a thoracic region of the spinal cord, the selected percentage is a third percentage if the longitudinal location is in a lumbar region of the spinal cord, and the selected percentage is a fourth percentage if the longitudinal location is in a sacral region of the spinal cord, wherein the second percentage is greater than the first percentage, the third percentage is greater than the second percentage, and the fourth percentage is greater than the third percentage.

7. The neuromodulation system of claim 6, wherein the fourth percentage is in the range of 50%-90% of the perception threshold, the third percentage is in the range of 40%-80% of the perception threshold, the second percentage is in the range of 30%-70% of the perception threshold, and the first percentage is in the range of 20%-60% of the perception threshold.

8. The neuromodulation system of claim 1, further comprising memory storing a look-up table containing a plurality of different percentages and associated neuromodulation lead locations, wherein the control/processing circuitry is configured for selecting the percentage by matching the known longitudinal location of the neuromodulation lead relative to the spinal cord with one of the neuromodulation lead locations stored in the look-up table and selecting the percentage associated with the matched neuromodulation lead location.

9. An external controller for use with a neuromodulation device coupled to at least one electrode, the external controller comprising:

a user interface configured for receiving user input;

control/processing circuitry configured for selecting a percentage from a plurality of percentages based on a known longitudinal location of the neuromodulation lead relative to the spinal cord, computing an amplitude value as a function of the selected percentage; and

output circuitry configured for transmitting the amplitude value to the neuromodulation device.

10. The external controller of claim 9, wherein the control/processing circuitry is configured for determining the known longitudinal location of the implanted neuromodulation lead relative to the spinal cord.

11. The external controller of claim 9, wherein the user interface is further configured for receiving user input defining the known longitudinal location of the implanted neuromodulation lead relative to the spinal cord.

12. The external controller of claim 9, wherein the control/processing circuitry is configured for computing the amplitude value as a function of the percentage and a perception threshold of the patient.

13. The external controller of claim 12, wherein the selected percentage is a first percentage if the longitudinal location is in a first region of the spinal cord, and the selected percentage is a second percentage if the longitudinal location is in a second region of the spinal cord, wherein the second percentage is higher than the first percentage, and the second region of the spinal cord is caudal to the first region of the spinal cord.

14. The external controller of claim 12, wherein the selected percentage is a first percentage if the longitudinal location is in a cervical region of the spinal cord, the selected percentage is a second percentage if the longitudinal location is in a thoracic region of the spinal cord, the selected percentage is a third percentage if the longitudinal location is in a lumbar region of the spinal cord, and the selected percentage is a fourth percentage if the longitudinal location is in a sacral region of the spinal cord, wherein the second percentage is greater than the first percentage, the third percentage is greater than the second percentage, and the fourth percentage is greater than the third percentage.

15. The external controller of claim 14, wherein the fourth percentage is in the range of 50%-90% of the perception threshold, the third percentage is in the range of 40%-80% of the perception threshold, the second percentage is in the range of 30%-70% of the perception threshold, and the first percentage is in the range of 20%-60% of the perception threshold.

16. The external controller of claim 9, further comprising memory storing a look-up table containing a plurality of different percentages and associated neuromodulation lead locations, wherein the control/processing circuitry is configured for selecting the percentage by matching the known longitudinal location of the neuromodulation lead relative to the spinal cord with one of the neuromodulation lead locations stored in the look-up table and selecting the percentage associated with the matched neuromodulation lead location.

17. A method of providing sub-threshold modulation therapy to a patient, comprising:

selecting a percentage from a plurality of percentages based on a known longitudinal location of the neuromodulation lead relative to the spinal cord;

computing an amplitude value as a function of the selected percentage; and

delivering sub-threshold modulation energy to the patient at the computed amplitude value.

18. The method of claim 17, further comprising:

determining the known longitudinal location of the neuromodulation lead relative to the spinal cord.

19. The method of claim 17, further comprising:

receiving user input defining the longitudinal location of the implanted neuromodulation lead relative to the spinal cord.

20. The method of claim 17, further comprising:

computing the amplitude value as a function of the percentage and a perception threshold of the patient,