SC-BETA CELLS AND COMPOSITIONS AND METHODS FOR GENERATING THE SAME
First Claim
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1. A composition comprising a non-native pancreatic β
- cell, wherein;
(a) the non-native pancreatic β
cell comprises one or more crystalline insulin granules;
(b) the non-native pancreatic β
cell expresses the following genes;
INS, PDX1, NKX6-1, and ZNT8; and
(c) the non-native pancreatic β
cell exhibits an in vitro glucose-stimulated insulin secretion response to a first glucose challenge and a second glucose challenge when the first glucose challenge and the second glucose challenge are applied sequentially.
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Abstract
Disclosed herein are methods, compositions, kits, and agents useful for inducing β cell maturation, and isolated populations of SC-β cells for use in various applications, such as cell therapy.
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23 Claims
-
1. A composition comprising a non-native pancreatic β
- cell, wherein;
(a) the non-native pancreatic β
cell comprises one or more crystalline insulin granules;(b) the non-native pancreatic β
cell expresses the following genes;
INS, PDX1, NKX6-1, and ZNT8; and(c) the non-native pancreatic β
cell exhibits an in vitro glucose-stimulated insulin secretion response to a first glucose challenge and a second glucose challenge when the first glucose challenge and the second glucose challenge are applied sequentially. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23)
- cell, wherein;
Specification