MANUFACTURE OF VASCULAR SMOOTH MUSCLE CELLS AND THE USE
First Claim
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1. A method for preparing brain-specific vascular smooth muscle cells, the method comprising the step of:
- (a) contacting a population of stem cells with a composition comprising a bone morphogenetic protein (BMP) antagonist, a fibroblast growth factor (FGF) and an activin or nodal inhibitor to produce a population of neural crest cells.
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Abstract
A method for preparing brain-specific vascular smooth muscle cells comprising the step of: (a) contacting a population of stem cells with a composition comprising a bone morphogenetic protein (BMP) antagonist, a fibroblast growth factor (FGF) and an activin or nodal inhibitor to produce a population of neural crest cells.
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24 Claims
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1. A method for preparing brain-specific vascular smooth muscle cells, the method comprising the step of:
(a) contacting a population of stem cells with a composition comprising a bone morphogenetic protein (BMP) antagonist, a fibroblast growth factor (FGF) and an activin or nodal inhibitor to produce a population of neural crest cells. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
- 23. A composition comprising a BMP antagonist which is noggin present in a concentration of about 200 ng/ml, a FGF which is bFGF present in a concentration of about 12 ng/ml, an activin or nodal inhibitor which is SB431542 present in a concentration of about 10 μ
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