PHARMA-INFORMATICS SYSTEM

• US 20150223751A1
• Filed: 01/13/2015
• Published: 08/13/2015
• Est. Priority Date: 04/28/2005
• Status: Active Grant

• Current Assignee: Proteus Digital Health, Inc. (Otsuka Holdings Company Limited)
• Original Assignee: Proteus Digital Health, Inc. (Otsuka Holdings Company Limited)
• Inventors: Zdeblick, Mark, Thompson, Andrew, Pikelny, Aleksandr, Robertson, Timothy, Hafezi, Hooman
• Granted Patent: US 9,681,842 B2
• Time in Patent Office: Days
• US Class Current: 1/1
• CPC Class Codes: A61B 2560/0214 of power generation or supply
• CPC Class Codes: A61B 2560/0462 Apparatus with built-in sensors
• CPC Class Codes: A61B 2562/08 Sensors provided with means for identification, e.g. barcodes or memory chips
• CPC Class Codes: A61B 2562/162 Capsule shaped sensor housings, e.g. for swallowing or implantation
• CPC Class Codes: A61B 5/0028 Body tissue as transmission medium, i.e. transmission systems where the medium is the human body
• CPC Class Codes: A61B 5/0031 Implanted circuitry
• CPC Class Codes: A61B 5/07 Endoradiosondes
• CPC Class Codes: A61B 5/073 Intestinal transmitters
• CPC Class Codes: A61B 5/076 Permanent implantations telemetry using implanted circuitry A61B5/0031; implanted stimulators for therapy A61N1/3605, A61N1/362, A61N1/372
• CPC Class Codes: A61B 5/1473 invasive, e.g. introduced into the body by a catheter A61B5/1482 takes precedence
• CPC Class Codes: A61B 5/4833 Assessment of subject's compliance to treatment
• CPC Class Codes: A61B 5/4839 combined with drug delivery
• CPC Class Codes: A61B 5/6861 Capsules, e.g. for swallowing or implanting
• CPC Class Codes: A61B 5/7282 Event detection, e.g. detecting unique waveforms indicative of a medical condition A61B5/4094, A61B5/4818, A61B5/349, A61B5/0823 take precedence
• CPC Class Codes: A61J 3/007 Marking tablets or the like apparatus for printing on tablets or the like B41F17/36
• CPC Class Codes: G06K 7/10168 the powering being adversely affected by environmental influences, e.g. unwanted energy loss in the interrogation signal due to metallic or capacitive objects in the proximity of the interrogation device or in the proximity of the interrogated record carrier
• CPC Class Codes: G06K 7/10366 the interrogation device being adapted for miscellaneous applications
• CPC Class Codes: G16H 20/10 relating to drugs or medications, e.g. for ensuring correct administration to patients
• CPC Class Codes: H01Q 1/273 Adaptation for carrying or wearing by persons or animals
• CPC Class Codes: H04B 13/005 Transmission systems in which the medium consists of the human body
• CPC Class Codes: H04W 4/80 : Services using short range communication, e.g. near-field communication [NFC], radio-frequency identification [RFID] or low energy communication
• CPC Class Codes: Y10T 29/49117 : Conductor or circuit manufacturing

Abstract

An apparatus including a coil configured to receive a signal associated with a composition ingested by a user and a data storage element operatively coupled to the coil, the data storage element configured to store, based on the signal, at least one of time information, date information, or identity information associated with the composition.

Claims

1. An apparatus, comprising:

a coil configured to receive a signal associated with a composition ingested by a user; and

a data storage element operatively coupled to the coil, the data storage element configured to store, based on the signal, at least one of time information, date information, or identity information associated with the composition.

2. The apparatus of claim 1, wherein the coil is configured to be positioned outside a body of the user to receive the signal.

3. The apparatus of claim 1, wherein the coil is disposed within at least one of a watch, a belt, a necklace or an earring configured to be worn by the user to receive the signal.

4. The apparatus of claim 1, wherein the coil is configured to receive the signal in response to an identifier of the composition conductively transmitting the signal in response to contacting an internal physiological site of the user.

5. The apparatus of claim 1, wherein the signal comprises the identity information associated with the composition.

6. The apparatus of claim 1, wherein the coil is configured to be positioned within a body of the user to receive the signal.

7. The apparatus of claim 1, further comprising:

a data transmission element configured to send, to an external device, at least one of the time information, the date information, or the identity information associated with the composition.

8. The apparatus of claim 1, wherein the composition comprises an active agent.

9. The apparatus of claim 1, wherein the signal is a conductive signal having a frequency between about 1 kHz to about 500 kHz.

10. The apparatus of claim 1, wherein the signal comprises an address associated with the composition, the identity information including the address, the data storage element configured to store the identity information.

11. An apparatus, comprising:

a detector configured to detect a signal associated with a composition ingested by a user, the detector configured to be at least partially disposed on a skin of the user when detecting the signal; and

a data storage element operatively coupled to the detector, the data storage element configured to store, based on the signal, at least one of time information, date information, or identity information associated with the composition.

12. The apparatus of claim 11, wherein the signal comprises the identity information associated with the composition.

13. The apparatus of claim 11, further comprising:

a data transmission element configured to send, to an external device, at least one of the time information, the date information, or the identity information associated with the composition.

14. The apparatus of claim 11, wherein the detector is disposed within at least one of a watch, a belt, a necklace or an earring configured to be worn by the user to detect the signal.

15. The apparatus of claim 11, wherein the composition comprises an active agent.

16. The apparatus of claim 11, wherein the detector is configured to detect the signal in response to an identifier of the composition conductively transmitting the signal in response to contacting an internal physiological site of the user.

17. The apparatus of claim 11, wherein the signal is a conductive signal having a frequency between about 1 kHz to about 500 kHz.

18. A method, comprising:

receiving, at a coil, a signal associated with a composition ingested by the user; and

storing, in a data storage element and based on the signal, at least one of time information, date information, or identity information associated with the composition.

19. The method of claim 18, wherein the coil is disposed within at least one of a watch, a belt, a necklace or an earring configured to be worn by the user.

20. The method of claim 18, further comprising:

send, to an external device and in response to the receiving, at least one of the time information, the date information, or the identity information associated with the composition.

21. The method of claim 18, wherein the signal comprises the identity information associated with the composition.

22. The method of claim 18, wherein the coil is positioned outside a body of the user.

23. The method of claim 18, wherein the receiving is in response to an identifier of the composition conductively transmitting the signal in response to contacting an internal physiological site of the user.

24. The method of claim 18, wherein the signal is a conductive signal having a frequency between about 1 kHz to about 500 kHz.

25. An apparatus, comprising:

a coil configured to detect a current signal within a physiological fluid; and

a data storage element operatively coupled to the coil, the data storage element configured to store, based on the current signal, at least one physiological datum.

26. The apparatus of claim 25, wherein the coil is configured to be positioned outside a user'"'"'s body containing the physiological fluid to receive the current signal.

27. The apparatus of claim 25, wherein the coil is disposed within at least one of a watch, a belt, a necklace or an earring configured to be worn by a user.

28. The apparatus of claim 25, wherein the current signal has a frequency between about 1 kHz to about 500 kHz.

29. An apparatus, comprising:

a detector configured to detect a monophasic signal associated with a composition ingested by a user; and

a data storage element operatively coupled to the detector, the data storage element configured to store, based on the monophasic signal, at least one of time information, date information, or identity information associated with the composition.

30. The apparatus of claim 29, wherein the monophasic signal is a conductive signal having a frequency between about 1 kHz to about 500 kHz.

31. The apparatus of claim 29, wherein the detector is disposed within at least one of a watch, a belt, a necklace or an earring configured to be worn by the user to detect the monophasic signal.

32. The apparatus of claim 29, wherein the monophasic signal is generated by a flow of ions between an anode and a cathode associated with the composition ingested by the user.

33. The apparatus of claim 29, wherein the monophasic signal is generated by current modulated in a single direction between two disparate materials.

34. The apparatus of claim 29, wherein the monophasic signal is generated by a reaction between two disparate materials in a physiological fluid.

35. A system, comprising:

an identifier comprising;

a partial power source comprising a first material and a second material, the partial power source configured to;

generate, upon contact with a conducting medium, a potential difference between the first material and the second material to provide power to a control device; and

generate, using the first material and the second material, a current flow within the conducting medium, the current flow encoding information based on a variable conductance between the first material and the second material; and

a membrane to define a path for the current flow; and

a receiver configured to communicate with the identifier, the receiver comprising a first coil configured to receive the information, wherein the information is associated with a composition ingested by a user.

36. The system of claim 35, wherein the identifier further comprises a second coil to receive an interrogation signal to apprise a transmitter of the interrogation signal of presence and identity of the identifier.

37. The system of claim 35, wherein the identifier further comprises:

a control device configured to produce the variable conductance between the first material and the second material when the partial power source is in contact with the conducting medium; and

a power receiver configured to receive broadcast power and transduce the broadcast power into a form suitable for driving the control device.

38. The system of claim 37, wherein the power receiver is a second coil.

39. The system of claim 37, wherein the receiver further comprises a data storage element operatively coupled to the first coil, the data storage element configured to store, based on the information, at least one of time information, date information, or identity information associated with the composition.

40. A system, comprising:

an identifier comprising;

a partial battery comprising a first electrode and a second electrode, the partial battery configured to;

generate, upon contact with a physiological fluid, a potential difference between the first electrode and the second electrode to provide power to a signal generationelement; and

generate, using the first electrode and the second electrode, a current within the physiological fluid when in contact with the physiological fluid to conductively transmit a signal; and

a first coil to receive an interrogation signal to apprise a transmitter of the interrogation signal of presence and identity of the identifier. and

a receiver configured to communicate with the identifier, the receiver comprising a second coil configured to receive the signal, wherein the signal is associated with a composition ingested by a user.

41. The system of claim 40, wherein the identifier further comprises a membrane to define a path for the current.

42. The system of claim 40, wherein the identifier further comprises a power receiver configured to receive broadcast power and transduce the broadcast power into a form suitable for driving the signal generation element.

43. The system of claim 42, wherein the power receiver is the first coil.

44. The system of claim 40, wherein the receiver further comprises a data storage element operatively coupled to the first coil, the data storage element configured to store, based on the signal, at least one of time information, date information, or identity information associated with the composition.

45. A system comprising:

an identifier comprising;

a partial battery comprising a first material and a second material, the partial battery configured to;

generate, upon contact of the first material and the second material with a physiological fluid, a potential difference between the first material and the second material using the physiological fluid as an electrolyte of the partial battery to provide power to a control device; and

modulate a current flow within the physiological fluid being used as the electrolyte and based on a variable conductance within the control device and between the first material and the second material; and

a membrane to define a path for the current flow; and

a receiver configured to communicate with the identifier, the receiver comprising a first coil configured to receive the current flow, wherein the current flow is associated with a composition ingested by a user.

46. The system of claim 45, wherein the identifier further comprises a second coil to receive an interrogation signal to apprise a transmitter of the interrogation signal of presence and identity of the identifier.

47. The system of claim 45, wherein the identifier further comprises a power receiver configured to receive broadcast power and transduce the broadcast power into a form suitable for driving the control device.

48. The system of claim 47, wherein the power receiver is a second coil.

49. The system of claim 45, wherein the receiver further comprises a data storage element operatively coupled to the first coil, the data storage element configured to store, based on the signal, at least one of time information, date information, or identity information associated with the composition.