INTRA-ABDOMINAL PRESSURE TO PROMOTE HEMOSTASIS AND SURVIVAL

• US 20150223819A1
• Filed: 01/15/2015
• Published: 08/13/2015
• Est. Priority Date: 08/24/2009
• Status: Active Grant

• Current Assignee: Arsenal Medical, Inc
• Original Assignee: Arsenal Medical, Inc
• Inventors: Rago, Adam, Marini, John, Zugates, Gregory T., Helmick, Marc, Sharma, Upma
• Granted Patent: US 9,820,749 B2
• Time in Patent Office: Days
• US Class Current: 1/1
• CPC Class Codes: A61B 17/12 for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord specially adapted for vas deferens or fallopian tubes A61F6/20; materials for ligaturing blood vessels A61L17/00
• CPC Class Codes: A61B 2017/12004 for haemostasis, for prevention of bleeding
• CPC Class Codes: A61L 24/0036 Porous materials, e.g. foams or sponges
• CPC Class Codes: A61L 24/046 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds A61L24/043 takes precedence
• CPC Class Codes: A61L 2400/04 Materials for stopping bleeding
• CPC Class Codes: A61M 13/003 Blowing gases other than for carrying powders, e.g. for inflating, dilating or rinsing
• CPC Class Codes: A61M 2205/3341 stabilising pressure or flow to avoid excessive variation
• CPC Class Codes: A61M 2205/3344 Measuring or controlling pressure at the body treatment site
• CPC Class Codes: A61M 2210/1021 Abdominal cavity
• CPC Class Codes: A61M 2210/12 Blood circulatory system
• CPC Class Codes: C08L 75/04 Polyurethanes

Abstract

Systems, methods and kits for treating hemorrhages within cavities are provided. The methods utilize the application of a rapid spike of pressure to the closed cavity, followed by a steady state pressure or pressures.

Claims

1. A method of treating a hemorrhage within a cavity, comprising the steps of:

applying a pressure to an interior boundary of the cavity, wherein the pressure is applied by an article placed into the cavity, and wherein the article is a foam, which is formed inside of the cavity by applying a formulation comprising at least one liquid phase into the cavity.

2. The method of claim 1, wherein the pressure is characterized by a transient peak value and wherein the transient peak value less than about 84 mmHg.

3. The method of claim 1, wherein the pressure is characterized by a transient peak value and wherein the transient peak value is at least about 51 mmHg.

4. The method of claim 1, wherein the pressure is characterized by a transient peak value and wherein the transient peak value is at least about 20 mmHg.

5. The method of claim 1, wherein the pressure is characterized by a transient peak value and at least one steady state value.

6. The method of claim 1, wherein the cavity is a human abdominal cavity.

7. The method of claim 1, wherein the formulation is applied in a dosage ranging from 45 mL to 100 mL.

8. The method of claim 1, wherein the formulation is applied in a dosage ranging from 45 mL to <

75 mL.

9. The method of claim 1, wherein the formulation is applied in a dosage ranging from 45 mL to 65 mL.

10. The method of claim 1, wherein a volume of the foam that is formed ranges from 900 mL to 3200 mL.

11. A kit for treating hemorrhage in a cavity of a patient, the kit comprising:

a formulation comprising at least one liquid phase, the formulation configured to form a foam when disposed into the cavity; and

instructions instructing a user to perform the method of claim 1.

12. The kit of claim 11, wherein the foam is configured to apply a pressure to an interior boundary of the body cavity, the pressure being characterized by a transient peak value that is less than about 84 mmHg.

13. The kit of claim 11, wherein the foam is configured to apply a pressure to an interior boundary of the body cavity, the pressure being characterized by a transient peak value that is at least about 51 mmHg.

14. The kit of claim 11, wherein the foam is configured to apply a pressure to an interior boundary of the body cavity, the pressure being characterized by a transient peak value that is at least about 20 mmHg.

15. The kit of claim 11, wherein the foam is configured to apply a pressure to an interior boundary of the body cavity, the pressure being characterized by a transient peak value and at least one steady state value.

16. The kit of claim 11, wherein the cavity is a human abdominal cavity.

17. The kit of claim 11, wherein the formulation is provided in a dosage ranging from 45 mL to 100 mL.

18. The kit of claim 11, wherein the formulation is provided in a dosage ranging from 45 mL to <

75 mL.

19. The kit of claim 11, wherein the formulation is provided in a dosage ranging from 45 mL to 65 mL.

20. The kit of claim 11, wherein a volume of the foam that is formed ranges from 900 mL to 3200 mL.