Antimicrobial Composition

• US 20150224072A1
• Filed: 08/30/2013
• Published: 08/13/2015
• Est. Priority Date: 09/03/2012
• Status: Active Application

• Current Assignee: Dutch Renewable Energy B.V
• Original Assignee: Dutch Renewable Energy B.V
• Inventors: Pellikaan, Hubert Clemens
• Application Number:
  US14/425,478
• Publication Number:
  US 20150224072A1
• Time in Patent Office: Days
• US Class Current: 1/1
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/047 having two or more hydroxy groups, e.g. sorbitol
• CPC Class Codes: A61K 31/19 Carboxylic acids, e.g. valproic acid salicylic acid A61K31/60
• CPC Class Codes: A61K 31/194 having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
• CPC Class Codes: A61K 31/20 having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
• CPC Class Codes: A61K 31/352 condensed with carbocyclic rings, e.g. methantheline cannabinoids A61K31/658
• CPC Class Codes: A61K 31/723 Xanthans
• CPC Class Codes: A61P 31/02 Local antiseptics
• CPC Class Codes: Y02A 50/30 Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

Provided herein is an antimicrobial composition having at least one free fatty acid or a derivative and/or a pharmaceutically acceptable salt thereof, wherein the free fatty acid has from 6 to 16 carbon atoms, at least one carboxylic acid or a pharmaceutically acceptable salt thereof and/or at least one carbohydrate or a pharmaceutically acceptable salt thereof, wherein the carbohydrate is selected from a hydrogenated carbohydrate, a monosaccharide, a disaccharide, a polysaccharide and combinations thereof. The antimicrobial composition provides enhanced anti-adhesion and/or disinfecting properties. The composition of the present invention can be formulated into a drink, gel or spray suitable for treating or preventing the first stage in pathogenesis.

Claims

1. Antimicrobial composition comprising:

a) at least one free fatty acid or a derivative and/or a pharmaceutically acceptable salt thereof, wherein the free fatty acid is selected from a free fatty acid having from 6 to 16 carbon atoms;

b) at least one carboxylic acid or a pharmaceutically acceptable salt thereof; and

/or

c) at least one carbohydrate or a pharmaceutically acceptable salt thereof, wherein the carbohydrate is selected from a hydrogenated carbohydrate, a monosaccharide, a disaccharide, a polysaccharide and combinations thereof.

2. Antimicrobial composition according to claim 1, wherein the free fatty acid is selected from saturated free fatty acid, unsaturated free fatty acid and combinations thereof, having from 7 to 14 carbon atoms, preferably having from 8 to 10 carbon atoms.

3. Antimicrobial composition according to claim 1 or 2, wherein the free fatty acid is selected from caproic acid, enanthic acid, pelargonic acid, caprylic acid, capric acid, undecanoic acid, undecylenic acid, lauric acid, myristic acid, palmitic acid and combinations thereof, and pharmaceutically acceptable salts and esters thereof.

4. Antimicrobial composition according to any of the preceding claims, wherein the free fatty acid is selected from caprylic acid, capric acid and combinations thereof, and pharmaceutically acceptable salts and esters thereof.

5. Antimicrobial composition according to any of the preceding claims, wherein the carboxylic acid is selected from alpha hydroxyl acids, diacids, polyacids and combinations thereof.

6. Antimicrobial composition according to any of the preceding claims, wherein the carboxylic acid is selected from glycolic acid, lactic acid, citric acid, mandelic acid, oxalic acid, malonic acid, succinic acid, glutaric acid, tartaric acid, adipic acid, pimelic acid, malic acid, maleic acid, fumaric acid and combinations thereof.

7. Antimicrobial composition according to any of the preceding claims, wherein the amount of carboxylic acid is in the range of about 0.01% to about 4% by weight of the total weight of the composition.

8. Antimicrobial composition according to any of the preceding claims, wherein the carbohydrate is selected from monosaccharides and/or disaccharides.

9. Antimicrobial composition according to any of the preceding claims, wherein the carbohydrate is selected from glucose, fructose, galactose, ribose, sucrose, maltose, lactose, xylitol, mannitol, sorbitol, erythritol and combinations thereof.

10. Antimicrobial composition according to any of the preceding claims, wherein the carbohydrate is selected from sucrose, xylitol, mannitol and combinations thereof.

11. Antimicrobial composition according to any of the preceding claims, wherein the organic acid is caprylic acid and the carbohydrate is xylitol.

12. Antimicrobial composition according to any of the preceding claims, wherein the composition further comprising at least one flavonoid or a pharmaceutically acceptable salt thereof.

13. Antimicrobial composition according to claim 12, wherein the flavonoid is selected from flavanols, flavones, anthocyanidins, isoflavonoids, neoflavonoids and combinations thereof.

14. Antimicrobial composition according to claim 12 or 13, wherein the flavonoid is a proanthocyanidin.

15. Antimicrobial composition according to any of the preceding claims, wherein the composition further comprising at least one flavouring agent, viscosity-enhancing agent, emulsifying agent, acidity-regulating agent, humectant and/or preservative.

16. Antimicrobial composition according to claim 15, wherein the amount of surfactant is less than 10% by weight of the total weight of free fatty acid present, preferably about 4% by weight of the total weight of free fatty acid present.

17. Antimicrobial composition according to any of the preceding claims, wherein the composition is dissolved in an aqueous medium.

18. Antimicrobial composition according to claim 17, wherein the aqueous medium has a pH in the range of about 5.5 to about 7.0, preferably a pH in the range of about 6.0 to about 6.5.

19. Pharmaceutical formulation comprising the composition of any of the preceding claims, wherein the formulation is in the form of a drink, gel, drops or spray.

20. Pharmaceutical formulation according to claim 19, wherein the formulation is in the form of a throat spray, mouthwash, nasal spray, ear drops, wound spray or wound gel.

21. Pharmaceutical formulation according to claim 19 or 20 for treating or preventing the first stage in pathogenesis.

22. Pharmaceutical formulation according to claim 19 or 20 for preventing or reducing the adhesion of gram-positive bacteria, gram-negative bacteria and/or other microorganism to human tissue.

23. Pharmaceutical formulation according to claim 22, wherein the gram-positive bacteria is selected from Staphylococcus aureus, Streptococcus pyogenes and/or Streptococcus faecalis, the gram-negative bacteria is selected from Escherichia coli, Enterobacter aerogenes, Enterobacter and/or Haemophilus influenzae and the other microorganism is selected from Candida albicans.

24. Use of a free fatty acid as an anti-adhesion agent, wherein the free fatty acid is selected from a free fatty acid having from 6 to 16 carbon atoms.

25. Use according to claim 24, wherein the free fatty acid is selected from caprylic acid, capric acid and combinations thereof.