COLON CLEANSING OF RESIDUAL STOOL AND SECRETIONS DURING COLONOSCOPY

• US 20150224127A1
• Filed: 04/22/2015
• Published: 08/13/2015
• Est. Priority Date: 10/14/2009
• Status: Abandoned Application

• Current Assignee: GI Innovations, PLLC
• Original Assignee: GI Innovations, PLLC
• Inventors: NIZAM, RAYEES
• Application Number:
  US14/693,390
• Publication Number:
  US 20150224127A1
• Time in Patent Office: Days
• US Class Current: 1/1
• CPC Class Codes: A61B 1/015 Control of fluid supply or evacuation
• CPC Class Codes: A61B 1/31 for the rectum, e.g. proctoscopes, sigmoidoscopes , colonoscopes
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/195 having an amino group
• CPC Class Codes: A61K 31/198 Alpha-amino acids, e.g. alanine or edetic acid [EDTA] betaine A61K31/205; proline A61K31/401; tryptophan A61K31/405; histidine A61K31/4172; peptides not degraded to individual amino acids A61K38/00
• CPC Class Codes: A61K 31/22 of acyclic acids, e.g. pravastatin
• CPC Class Codes: A61K 31/225 Polycarboxylic acids
• CPC Class Codes: A61K 31/695 Silicon compounds
• CPC Class Codes: A61K 31/80 Polymers containing hetero atoms not provided for in groups A61K31/755 - A61K31/795
• CPC Class Codes: A61K 9/0053 Mouth and digestive tract, i.e. intraoral and peroral administration rectal administration A61K9/0031
• CPC Class Codes: A61K 9/08 Solutions composition of solutions A61K47/00
• CPC Class Codes: A61M 31/00 Devices for introducing or retaining media, e.g. remedies, in cavities of the body A61M25/00 takes precedence ; introducing or retaining ophthalmic products into the ocular cavities A61F9/0008
• CPC Class Codes: A61P 1/00 Drugs for disorders of the alimentary tract or the digestive system
• CPC Class Codes: A61P 1/10 Laxatives
• CPC Class Codes: G06Q 30/0239 Online discounts or incentives
• CPC Class Codes: G06Q 30/0241 Advertisements
• CPC Class Codes: H04L 51/04 Real-time or near real-time messaging, e.g. instant messaging [IM]
• CPC Class Codes: H04L 51/216 Handling conversation history, e.g. grouping of messages in sessions or threads
• CPC Class Codes: H04W 4/025 using location based information parameters

Abstract

This invention relates, e.g., to a composition comprising two or more of: (a) N-acetylcysteine and/or (b) simethicone and/or (c) a docusate salt. In one embodiment of the invention, the amounts of (a) and/or (b) and/or (c) are effective, when the composition is administered into a colon of a subject undergoing colonoscopy, to cleanse a region of the colon in the visual field of the colonoscope so that the region contains no adherent stool or intestinal secretions obscuring the visual field. Methods for using this or other compositions of the invention, e.g. to cleanse the colon of a subject in order to enhance visualization of the colon during a colonoscopy, are also described, as are kits for carrying out methods of the invention.

Claims

1. A composition comprising two or more of:

a) N-acetylcysteine, or

b) simethicone, or

c) a docusate salt.

2. The composition of claim 1, wherein the amounts of a) and/or b) and/or c) are effective when the composition is administered into a colon of a subject undergoing colonoscopy to cleanse a region of the colon in the visual field of the colonoscope so that the region contains no adherent stool or intestinal secretions obscuring the visual field.

3. The composition of claim 1, wherein the composition is effective, when administered orally to a subject, to reduce the amount of adherent stool and/or intestinal secretions in the colon of the subject.

7. The composition of claim 1, formulated as a liquid,

wherein the N-acetylcysteine is packaged separately from the other components and is added to them no more than about 96 hours before the composition is to be used.

11. The method of claim 8, wherein introduction into the colon through the colonoscope comprises

operating a pump which is operably linked via a conduit to a container that comprises the composition of claim 1, allowing inflow of the composition from the container to the pump, and is also operably linked via a channel to a colonoscope, allowing outflow of the composition from the pump to the channel in the colonoscope,

thereby administering the composition to the colon.

12. The method of claim 8, wherein introduction into the colon through the colonoscope comprises

introducing, with a syringe, composition of claim 1 into a channel in the colonoscope,

thereby administering the composition to the subject.

16. A method for treating constipation in a patient in need thereof comprising administering to the patient the composition of claim 1.

17. A method for decreasing abdominal discomfort in a patient in need thereof comprising administering to the patient the composition of claim 1.

18. A kit comprising:

a) the composition claim 1; and

b) a container that is suitable for administering the composition to a subject via a colonoscope.

19. The kit of claim 18, wherein the container is a plastic container.

4. The composition of claim 4, further comprising a solvent, wherein the concentrations of a), b), and c) are:

a) N-acetylcysteine;

from about 20 mg to 20 g/L,

b) simethicone;

from about 3 mg to 3 g/L,

c) a docusate salt;

from about 2 mg to 2 g/L.

5. The composition of claim 4, wherein the N-acetylcysteine is in an amount of about 2 g/L.

6. The composition of claim 4, wherein the simethicone is in an amount of about 600 mg/L.

8. A method for cleansing the colon of a subject, comprising introducing into the colon of the subject, through a channel in a colonoscope, a liquid form of a composition comprising one or more of:

a) N-acetylcysteine and/or

b) simethicone and/or

c) a docusate salt,

provided that N-acetylcysteine or docusate salt is not administered by itself,

wherein the amounts of a), b) and c), are effective, when administered through a colonoscope, in two or fewer flushes, to cleanse stool from the colon of the subject such that a region of the colon in the visual field of the colonoscope contains substantially no adherent stool or intestinal secretions.

10. The method of claim 8, wherein the purgative is polyethylene glycol.

13. The method of claim 8, wherein administering the composition occurs before the day of the patient'"'"'s colonoscopy.

14. The method of claim 8, wherein administering the composition occurs on the day of the patient'"'"'s colonoscopy.

15. The method of claim 8, wherein administering the composition occurs simultaneously with the patient'"'"'s colonoscopy.

9. A method for enhancing the ability of a purgative to cleanse the colon of a subject, comprising orally administering to the subject, before, during, or after administering the purgative, a composition comprising one or more of:

a) N-acetylcysteine and/or

b) simethicone and/or

c) a docusate salt,

provided that N-acetylcysteine or docusate salt is not administered by itself,

wherein the amounts of a), b) and c), are effective to enhance the amount of adherent stool and/or intestinal secretions in the colon of the subject.