COLON CLEANSING OF RESIDUAL STOOL AND SECRETIONS DURING COLONOSCOPY
First Claim
1. A composition comprising two or more of:
- a) N-acetylcysteine, orb) simethicone, orc) a docusate salt.
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Abstract
This invention relates, e.g., to a composition comprising two or more of: (a) N-acetylcysteine and/or (b) simethicone and/or (c) a docusate salt. In one embodiment of the invention, the amounts of (a) and/or (b) and/or (c) are effective, when the composition is administered into a colon of a subject undergoing colonoscopy, to cleanse a region of the colon in the visual field of the colonoscope so that the region contains no adherent stool or intestinal secretions obscuring the visual field. Methods for using this or other compositions of the invention, e.g. to cleanse the colon of a subject in order to enhance visualization of the colon during a colonoscopy, are also described, as are kits for carrying out methods of the invention.
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Citations
19 Claims
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1. A composition comprising two or more of:
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a) N-acetylcysteine, or b) simethicone, or c) a docusate salt. - View Dependent Claims (2, 3, 7, 11, 12, 16, 17, 18, 19)
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4. The composition of claim 4, further comprising a solvent, wherein the concentrations of a), b), and c) are:
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a) N-acetylcysteine;
from about 20 mg to 20 g/L,b) simethicone;
from about 3 mg to 3 g/L,c) a docusate salt;
from about 2 mg to 2 g/L. - View Dependent Claims (5, 6)
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8. A method for cleansing the colon of a subject, comprising introducing into the colon of the subject, through a channel in a colonoscope, a liquid form of a composition comprising one or more of:
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a) N-acetylcysteine and/or b) simethicone and/or c) a docusate salt, provided that N-acetylcysteine or docusate salt is not administered by itself, wherein the amounts of a), b) and c), are effective, when administered through a colonoscope, in two or fewer flushes, to cleanse stool from the colon of the subject such that a region of the colon in the visual field of the colonoscope contains substantially no adherent stool or intestinal secretions. - View Dependent Claims (10, 13, 14, 15)
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9. A method for enhancing the ability of a purgative to cleanse the colon of a subject, comprising orally administering to the subject, before, during, or after administering the purgative, a composition comprising one or more of:
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a) N-acetylcysteine and/or b) simethicone and/or c) a docusate salt, provided that N-acetylcysteine or docusate salt is not administered by itself, wherein the amounts of a), b) and c), are effective to enhance the amount of adherent stool and/or intestinal secretions in the colon of the subject.
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Specification