SPINAL CORD PULSATION-CANCELATION INJECTION SYSTEM

• US 20150224331A1
• Filed: 09/23/2013
• Published: 08/13/2015
• Est. Priority Date: 09/24/2012
• Status: Abandoned Application

• Current Assignee: Regents of the University of California (University of California)
• Original Assignee: Regents of the University of California (University of California)
• Inventors: Marsala, Martin
• Application Number:
  US14/430,384
• Publication Number:
  US 20150224331A1
• Time in Patent Office: Days
• US Class Current: 1/1
• CPC Class Codes: A61B 17/3401 Puncturing needles for the peridural or subarachnoid space or the plexus, e.g. for anaesthesia local anaesthesia A61M19/00
• CPC Class Codes: A61B 2017/00694 with means correcting for movement of or for synchronisation with the body
• CPC Class Codes: A61B 2017/00876 magnetic
• CPC Class Codes: A61B 2017/3407 including a base for support on the body
• CPC Class Codes: A61M 2202/09 Body tissue
• CPC Class Codes: A61M 2202/206 Viruses
• CPC Class Codes: A61M 2210/1003 Spinal column
• CPC Class Codes: A61M 25/06 Body-piercing guide needles or the like
• CPC Class Codes: A61M 37/00 Other apparatus for introducing media into the body for reproduction or fertilisation A61B17/425; apparatus for iontophoresis or cataphoresis A61N1/30; Percutany, i.e. introducing medicines into the body by diffusion through the skin salt baths A61H33/04
• CPC Class Codes: A61M 5/32 Needles; Details of needles pertaining to their connection with syringe or hub infusion needles A61M5/158; Accessories for bringing the needle into, or holding the needle on, the body A61M5/42, A61M5/46 take precedence; guide needles for catheters A61M25/065; Devices for protection of needles apparatus specially adapted for cleaning or sterilising needles A61M5/001
• CPC Class Codes: A61N 2/002 in combination with another treatment

Abstract

Delivery devices, systems, and methods related thereto may be used in humans for spinal delivery of cells, drugs or vectors. The patient population may include patients with spinal traumatic injury, amyotrophic lateral sclerosis, multiple sclerosis, spinal ischemia and any other spinal neurodegenerative disorders which will require spinal cell, vector or drug delivery. The delivery device compensates for spinal cord pulsation during such injections.

Claims

1. A spinal cord pulsation-cancelation injection device comprising:

(a) a frame having an elongated body and a plurality of holders extending therefrom;

(b) a plurality of first magnets, each being fixedly attached to a holder;

(c) a tube having a first end and a second end, the tube being slidingly disposed within through-holes disposed in each holder and in each first magnet;

(d) a plurality of second magnets fixedly attached to an exterior surface of the tube; and

(e) a needle fixedly attached to the first end of the tube.

2. The spinal cord pulsation-cancelation injection device according to claim 1, wherein each of the first magnets and the each of the second magnets are disposed such that a north pole of one first magnet faces a north pole of one second magnet or a south pole of one first magnet faces a south pole of one second magnet, thereby providing a magnetic repulsive force upon which the tube floats.

3. The spinal cord pulsation-cancelation injection device according to claim 1, wherein the frame comprises two holders, each having attached thereto a first magnet, and a single second magnet is fixedly attached to the tube.

4. The spinal cord pulsation-cancelation injection device according to claim 1, wherein the frame comprises two holders, each having attached thereto a first magnet, and two second magnets are fixedly attached to the tube.

5. The spinal cord pulsation-cancelation injection device according to claim 1, further comprising a stop ring fixedly attached to the first end of the tube or an area near the first end of the tube.

6. The spinal cord pulsation-cancelation injection device according to claim 1, further comprising a stop ring fixedly attached to the second end of the tube or an area near the second end of the tube.

7. The spinal cord pulsation-cancelation injection device according to claim 1, wherein the frame is made from stainless steel.

8. The spinal cord pulsation-cancelation injection device according to claim 1, wherein the needle is from about 27 to about 32 gauge.

9. The spinal cord pulsation-cancelation injection device according to claim 1, further comprising tubing removably attached to the second end of the tube and configured for supplying a substrate to the needle.

10. A spinal cord pulsation-cancelation injection system comprising:

(a) the spinal cord pulsation-cancelation injection device according to claim 1; and

(b) a reservoir in fluid communication with the needle, the reservoir containing a substrate to be administered to a subject.

11. The system according to claim 10, further comprising a digital microinjector configured to control flow of the substrate through the needle.

12. The system according to claim 10, wherein the substrate is selected from the group consisting of cells, drugs, viruses, plasmids, and growth factors.

13. The system according to claim 10, wherein the frame comprises two holders, each having attached thereto a first magnet, and a single second magnet is fixedly attached to the tube.

14. The system according to claim 10, wherein the frame comprises two holders, each having attached thereto a first magnet, and two second magnets are fixedly attached to the tube.

15. A method of compensating for spinal cord pulsation during administration of a substrate to a spinal cord of a subject comprising:

(a) positioning the spinal cord pulsation-cancelation injection system according to claim 10 over the spinal cord of the subject;

(b) lowering the needle into the spinal cord; and

(c) delivering a dose of the substrate to the spinal cord,

wherein the needle and tube of the device float due to magnetic repulsive forces within the device, thereby compensating for spinal cord pulsation.

16. The method of claim 15, further comprising repeating each of the steps at multiple sites along the spinal cord.

17. The method of claim 15, wherein the step of delivering comprises activating a digital microinjector configured to control flow of the substrate through the needle.

18. The method of claim 15, wherein the step of lowering the needle comprises inserting the needle into the spinal parenchyma until a needle stop ring that is fixedly attached to the needle contacts the subject.