BULK FREEZE DRYING USING SPRAY FREEZING AND AGITATED DRYING

• US 20150226478A1
• Filed: 04/03/2015
• Published: 08/13/2015
• Est. Priority Date: 08/04/2010
• Status: Active Grant

• Current Assignee: IMA LIFE North America Inc.
• Original Assignee: IMA LIFE North America Inc.
• Inventors: DeMarco, Francis W., Renzi, Ernesto, Ganguly, Arnab
• Granted Patent: US 9,945,611 B2
• Time in Patent Office: Days
• US Class Current: 1/1
• CPC Class Codes: F26B 5/065 the product to be freeze-dried being sprayed, dispersed or pulverised

Abstract

A freeze dryer processes bulk powder products. The freeze dryer freezes the product by mixing an atomized spray of product with sterile liquid nitrogen. The resultant powder is freeze dried in a vessel, and the vessel contents is agitated to maintain product contact with heated vessel wall and to prevent agglomeration.

Claims

1. A freeze drying system for freeze drying bulk product by removing a liquid, comprising:

a freezing chamber;

at least one spray nozzle directed to an interior of the freezing chamber, the at least one spray nozzle being connected for spraying the bulk product and a freezing agent, the at least one spray nozzle being configured to spray the bulk product and the freezing agent in the interior of the freezing chamber to create a spray-frozen powder;

a vacuum drying chamber;

a selectively closeable conduit connecting the freezing chamber with the vacuum drying chamber, the selectively closeable conduit having an open configuration for transferring the spray-frozen powder without using trays and shelves, the selectively closeable conduit further having a closed configuration for conducting a drying operation under vacuum in the vacuum drying chamber while conducting a different stage of freeze drying in the freezing chamber;

an agitating mechanism for agitating the spray-frozen powder in the vacuum drying chamber to move particles of the spray-frozen powder into and out of contact with a wall of the drying chamber;

a heater for heating the wall of the vacuum drying chamber;

a condensing chamber in communication with the vacuum drying chamber and comprising surfaces for condensing a vapor from exhaust gas received from the vacuum drying chamber; and

a vacuum pump in communication with the condensing chamber.

2. The system of claim 1, further comprising a controller including memory storing a program that, when executed by the controller, causes the freeze drying system to perform:

an aseptic spray freezing cycle wherein the bulk product and the freezing agent are sprayed from the at least one spray nozzle, to produce a spray frozen powder in the freezing chamber at a first pressure;

a transfer cycle wherein the selectively closeable conduit is configured in the open configuration and the spray frozen powder is transferred from the freezing chamber to the vacuum drying chamber; and

an aseptic vacuum freeze drying cycle wherein the selectively closeable conduit is configured in the closed configuration and the vacuum pump evacuates the condensing chamber and the vacuum drying chamber to a vacuum pressure lower than the first pressure, the heater heats the wall of the vacuum drying chamber and the agitating mechanism agitates the spray frozen powder.

3. The system of claim 2, wherein the aseptic spray freezing cycle and the aseptic vacuum freeze drying cycle are performed concurrently on different bulk product batches.

4. The system of claim 1, wherein the agitating mechanism comprises a vibrating mechanism externally mounted to the vacuum drying chamber.

5. The system of claim 1, wherein the agitating mechanism comprises a vibrating mechanism mounted to a supporting leg of the vacuum drying chamber.

6. The system of claim 1, wherein the agitating mechanism comprises a sterile gas introduction system configured to fluidize the spray-frozen powder.

7. The system of claim 6, wherein the agitating mechanism further comprises a mechanism selected from the group consisting of a vibration mechanism and a stirring mechanism.

8. The system of claim 1, wherein the freezing agent is sterile liquid nitrogen.

9. The system of claim 1, wherein a lower portion of the vacuum drying chamber is conical in shape.

10. The system of claim 1, wherein the heater is an electrical heater.

11. The system of claim 1, wherein the heater is a jacket for circulating a heated fluid.

12. The system of claim 1, further comprising

a jacket attached to the freezing chamber for circulating a cooled fluid for cooling the freezing chamber during spraying;

and

a heat exchanger for cooling the cooled fluid using gas vented from a source of the freezing agent.

13. The system of claim 1, wherein each one of the at least one spray nozzles is connected for spraying both the bulk product and the freezing agent.

14. The system of claim 1, wherein the at least one spray nozzle comprises at least one nozzle connected for spraying only the bulk product and at least one nozzle connected for spraying only the freezing agent.

15. A method for freeze drying a bulk product containing a liquid, comprising:

spraying the bulk product and a freezing agent into the freezing chamber, the freezing chamber being at a first pressure, the freezing agent intermingling with the sprayed bulk product to freeze the liquid contained in the bulk product to form a spray-frozen powder in the freezing chamber;

transferring the spray-frozen powder from the freezing chamber to a vacuum drying chamber;

subjecting the vacuum drying chamber to a vacuum pressure lower than the first pressure;

agitating the spray-frozen powder under the vacuum pressure in the vacuum drying chamber using an agitating mechanism to bring particles of the spray-frozen powder into and out of contact with a wall of the vacuum drying chamber;

during the agitating the spray-frozen powder under the vacuum pressure in the vacuum drying chamber, heating the spray-frozen powder to cause sublimation of frozen liquid to form a freeze dried product.

16. The method of claim 15, wherein the freezing agent is sterile liquid nitrogen.

17. The method of claim 15, wherein the bulk product and the freezing agent are sprayed from separate nozzles into the freezing chamber.

18. The method of claim 15, wherein the bulk product and the freezing agent are sprayed from at least one common nozzle into the freezing chamber.

19. The method of claim 15, wherein operations performed in the freezing chamber are performed concurrently with operations performed in the vacuum drying chamber, on different batches of the bulk product.

20. The method of claim 15, wherein heating the frozen powder comprises transferring heat to the wall of the vacuum drying chamber using a heat transfer fluid.

21. The method of claim 15, further comprising:

removing heat from a wall of the freezing chamber during the spraying using a heat transfer fluid cooled using vented gas from production of the freezing agent.

22. The method of claim 15, further comprising:

condensing vapor from the sublimation of the frozen liquid in a condensing chamber.

23. The method of claim 15, wherein transferring the frozen powder from the freezing chamber to the vacuum drying chamber comprises configuring a selectively closeable conduit connecting the freezing chamber with the vacuum drying chamber from a closed configuration to an open configuration.

24. The method of claim 15, wherein agitating the frozen powder under vacuum in the vacuum drying chamber using an agitating mechanism comprises vibrating a wall of the vacuum drying chamber.

25. The method of claim 15, wherein agitating the frozen powder under vacuum in the vacuum drying chamber using an agitating mechanism comprises introducing a sterile gas into the spray-frozen product to form a fluidized bed.