COMBINATIONS OF 5-HT2A INVERSE AGONISTS AND ANTAGONISTS WITH ANTIPSYCHOTICS
First Claim
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1. A method of treating a condition amenable to treatment with an antipsychotic, comprising:
- administering a first amount of a 5-HT2A inverse agonist or antagonist; and
administering a second amount of an antipsychotic agent, wherein the first and second amounts are such that an efficacious effect is achieved faster than when the antipsychotic agent is administered alone at an efficacious dose.
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Abstract
Combinations of 5-HT2A inverse agonists or antagonists such as pimavanserin with antipsychotics such as risperidone are shown induce a rapid onset of antipsychotic action and increase the responders when compared to therapy with the antipsychotic alone. These effects can be achieved at a low dose of the antipsychotic, thereby reducing the incidence of side effects. The combinations are also effective at decreases the incidence of weight gain and increased glucose or prolactin levels caused by the antipsychotic.
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Citations
70 Claims
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1. A method of treating a condition amenable to treatment with an antipsychotic, comprising:
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administering a first amount of a 5-HT2A inverse agonist or antagonist; and administering a second amount of an antipsychotic agent, wherein the first and second amounts are such that an efficacious effect is achieved faster than when the antipsychotic agent is administered alone at an efficacious dose. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29)
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- 30. A method of inducing a rapid onset of an antipsychotic effect, comprising co-administering a 5-HT2A inverse agonist or antagonist and an antipsychotic agent to a subject suffering from psychosis such that there is a rapid onset of antipsychotic effect.
- 33. A method of inducing a rapid onset of an antidepressant effect, comprising co-administering a 5-HT2A inverse agonist or antagonist and an antipsychotic agent to a subject suffering from depression such that there is a rapid onset of antidepressant effect.
- 35. A method of increasing the percentage of patients responding to antipsychotic therapy, comprising co-administering a 5-HT2A inverse agonist or antagonist and an antipsychotic agent to a subject suffering from psychosis such that a greater percentage of patients experience an efficacious effect than when the antipsychotic agent is administered alone at an efficacious dose.
- 38. A method of reducing or preventing weight gain associated with administration of an antipsychotic agent, comprising co-administering a 5-HT2A inverse agonist or antagonist with the antipsychotic agent to a subject at risk or of suffering from weight gain associated with administration of an antipsychotic agent.
- 41. A method of increasing patient compliance during antipsychotic therapy, comprising, co-administering a 5-HT2A inverse agonist or antagonist with an antipsychotic agent, wherein the doses of co-administration are such that patient compliance is increased as compared to compliance when administering an efficacious dose of the antipsychotic agent alone.
- 44. A method of reducing or preventing hyperprolactinemia caused by administration of risperidone, comprising co-administering a 5-HT2A inverse agonist or antagonist with less than 6 mg per day of risperidone to a subject at risk of or suffering from hyperprolactinemia associated with administration of risperidone.
- 46. A method of reducing or preventing increased serum glucose associated with administration of an antipsychotic-agent, comprising co-administering a 5-HT2A inverse agonist or antagonist with the antipsychotic agent to a subject at risk of or suffering from increased serum glucose associated with administration of an antipsychotic agent.
- 49. A method of reducing or preventing increased serum glucose and reducing or preventing weight gain associated with administration of an antipsychotic agent, comprising co-administering a 5-HT2A inverse agonist or antagonist with the antipsychotic agent to a subject at risk of or suffering from increased serum glucose and weight gain associated with administration of an antipsychotic agent.
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52. A pharmaceutical composition, comprising:
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a first amount of a 5-HT2A inverse agonist or antagonist; and a second amount of an antipsychotic agent, wherein the first and second amounts are such that when the composition is administered, an efficacious antipsychotic effect is achieved faster than when the antipsychotic agent is administered alone at an efficacious dose. - View Dependent Claims (53, 54, 55, 56)
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57. A package, comprising:
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a first amount of a 5-HT2A inverse agonist or antagonist; and instructions for administering the first amount of the 5-HT2A inverse agonist or antagonist and a second amount of an antipsychotic agent, wherein the first and second amounts are such that an efficacious antipsychotic effect is achieved faster than when the antipsychotic agent is administered alone at an efficacious dose. - View Dependent Claims (58, 59, 60, 61)
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62. A method of treatment, comprising:
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determining that a first pharmaceutical agent modulates a pharmacological property of a second pharmaceutical agent; determining that the first pharmaceutical agent has a longer half-life than a second pharmaceutical agent; and co-administering the first and second pharmaceutical agent to a patient. - View Dependent Claims (63, 64, 65, 66, 67, 68)
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69. A method of determining whether a test therapeutic agent is a good candidate for combination therapy with a therapeutic agent having a first half-life, comprising:
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obtaining a test therapeutic agent having a second half-life that is longer than said first half-life; and evaluating whether administering said test therapeutic agent in combination with said therapeutic agent allows said therapeutic agent to be efficacious at a level at which it is not efficacious when administered alone. - View Dependent Claims (70)
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Specification