HYBRID BLOCK COPOLYMER MICELLES WITH MIXED STEREOCHEMISTRY FOR ENCAPSULATION OF HYDROPHOBIC AGENTS

• US 20150232616A1
• Filed: 02/05/2015
• Published: 08/20/2015
• Est. Priority Date: 04/30/2007
• Status: Abandoned Application

• Current Assignee: Intezyne Technologies
• Original Assignee: Intezyne Technologies
• Inventors: Sill, Kevin N., Skaff, Habib, Breitenkamp, Kurt
• Application Number:
  US14/615,383
• Publication Number:
  US 20150232616A1
• Time in Patent Office: Days
• US Class Current: 1/1
• CPC Class Codes: A61K 47/34 Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers A61K47/10 takes precedence
• CPC Class Codes: A61K 9/1075 Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers A61K9/0026 takes precedence
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: C08G 2261/126 block
• CPC Class Codes: C08G 65/2627 containing aromatic or arylaliphatic amine groups
• CPC Class Codes: C08G 65/325 containing nitrogen
• CPC Class Codes: C08G 65/33341 aromatic
• CPC Class Codes: C08G 69/08 derived from amino-carboxylic acids
• CPC Class Codes: C08G 73/028 Polyamidoamines
• CPC Class Codes: C08J 2377/04 Polyamides derived from alpha-amino carboxylic acids C08J2377/10 takes precedence
• CPC Class Codes: C08J 3/03 in aqueous media
• CPC Class Codes: C08L 2203/02 for biomedical use
• CPC Class Codes: Y10S 930/29 Polyamino acid or polypeptide with an uninterrupted series of peptide repeating units
• CPC Class Codes: Y10S 977/773 Nanoparticle, i.e. structure having three dimensions of 100 nm or less
• CPC Class Codes: Y10S 977/906 Drug delivery

Abstract

The present invention relates to the field of polymer chemistry and more particularly to multiblock copolymers and micelles comprising the same.

Claims

1-28. -28. (canceled)

29. A multiblock copolymer of formula I:

30. The multiblock copolymer according to claim 29, wherein R^y consists of a mixture of R^y consists of a mixture of D-leucine and L-tyrosine amino acid side-chain groups.

31. The multiblock copolymer according to claim 29, wherein R^y consists of a mixture of D- and L-amino acid side-chain groups selected from:

D-benzylglutamate and L-benzylglutamate, or

D-benzylaspartate and L-benzylaspartate.