SYSTEMS AND METHODS FOR AUTOMATED OPTIMIZATION OF A MULTI-MODE INDUCTIVELY COUPLED PLASMA MASS SPECTROMETER
First Claim
1. A system for automated optimization (tuning) of a multi-mode inductively coupled plasma mass spectrometer (ICP-MS), the system comprising:
- a multi-mode inductively coupled plasma mass spectrometer (ICP-MS);
a processor and a non-transitory computer readable medium storing instructions thereon, wherein the instructions, when executed, cause the processor to;
receive user data input regarding an optimization to be performed on the ICP-MS, wherein the user data input comprises an identification of one or more selected modes of operation in which the ICP-MS is to be operated;
receive a user input for initiating an automated optimization routine for the ICP-MS; and
following receipt of the user input for initiating the routine, transmit a signal to the ICP-MS to perform the automated optimization routine, wherein the automated optimization routine comprises a plurality of steps performed in a sequence prescribed by the processor.
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Abstract
The present disclosure provides methods and systems for automated tuning of multimode inductively coupled plasma mass spectrometers (ICP-MS). In certain embodiments, a ‘single click’ optimization method is provided for a multi-mode ICP-MS system that automates tuning of the system in one or more modes selected from among the multiple modes, e.g., a vented cell mode, a reaction cell mode (e.g., dynamic reaction cell mode), and a collision cell mode (e.g., kinetic energy discrimination mode). Workflows and computational routines, including a dynamic range optimization technique, are presented that provide faster, more efficient, and more accurate tuning.
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Citations
41 Claims
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1. A system for automated optimization (tuning) of a multi-mode inductively coupled plasma mass spectrometer (ICP-MS), the system comprising:
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a multi-mode inductively coupled plasma mass spectrometer (ICP-MS); a processor and a non-transitory computer readable medium storing instructions thereon, wherein the instructions, when executed, cause the processor to; receive user data input regarding an optimization to be performed on the ICP-MS, wherein the user data input comprises an identification of one or more selected modes of operation in which the ICP-MS is to be operated; receive a user input for initiating an automated optimization routine for the ICP-MS; and following receipt of the user input for initiating the routine, transmit a signal to the ICP-MS to perform the automated optimization routine, wherein the automated optimization routine comprises a plurality of steps performed in a sequence prescribed by the processor. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. A method for automated optimization (tuning) of a multi-mode inductively coupled plasma mass spectrometer (ICP-MS), the method comprising:
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receiving, by a processor of a computing device, user data input regarding an optimization to be performed on a multi-mode inductively coupled plasma mass spectrometer (ICP-MS), wherein the user data input comprises an identification of one or more selected modes of operation in which the ICP-MS is to be operated; receiving, by the processor, a user input for initiating an automated optimization routine for the ICP-MS; and
,following receipt of the user input for initiating the routine, transmitting, by the processor, a signal to the ICP-MS to perform the automated optimization routine, wherein the automated optimization routine comprises a plurality of steps performed in a sequence prescribed by the processor. - View Dependent Claims (15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28)
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29. A non-transitory computer readable medium having instructions stored thereon, wherein the instructions, when executed by a processor, cause the processor to:
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receive user data input regarding an optimization to be performed on a multi-mode inductively coupled plasma mass spectrometer (ICP-MS), wherein the user data input comprises an identification of one or more selected modes of operation in which the ICP-MS is to be operated; receive a user input for initiating an automated optimization routine for the ICP-MS; and
,following receipt of the user input for initiating the routine, transmit a signal to the ICP-MS to perform the automated optimization routine, wherein the automated optimization routine comprises a plurality of steps performed in a sequence prescribed by the processor. - View Dependent Claims (30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41)
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Specification