MOLDING COMPACT, AND MANUFACTURING METHOD FOR TRANSDERMAL ABSORPTION SHEET

• US 20150238743A1
• Filed: 05/12/2015
• Published: 08/27/2015
• Est. Priority Date: 11/13/2012
• Status: Active Grant

• Current Assignee: Fujifilm Corporation (Fujifilm Holdings Corporation)
• Original Assignee: Fujifilm Corporation (Fujifilm Holdings Corporation)
• Inventors: CHE, Yanlong, OYAMADA, Takayoshi, OGAWA, Shotaro, YOSHIDA, Junya
• Granted Patent: US 10,029,081 B2
• Time in Patent Office: Days
• US Class Current: 1/1
• CPC Class Codes: A61K 9/0021 Intradermal administration, e.g. through microneedle arrays, needleless injectors mechanical aspects A61M
• CPC Class Codes: A61M 2037/0046 Solid microneedles
• CPC Class Codes: A61M 2037/0053 Methods for producing microneedles
• CPC Class Codes: A61M 2207/10 Device therefor
• CPC Class Codes: A61M 37/0015 by using microneedles
• CPC Class Codes: B29C 2033/385 by laminating a plurality of layers
• CPC Class Codes: B29C 33/3857 by making impressions of one or more parts of models, e.g. shaped articles and including possible subsequent assembly of the parts
• CPC Class Codes: B29C 33/40 Plastics, e.g. foam or rubber
• CPC Class Codes: B29C 33/424 Moulding surfaces provided with means for marking or patterning for injection moulding B29C45/372
• CPC Class Codes: B29L 2031/7544 Injection needles, syringes
• CPC Class Codes: B29L 2031/756 Microarticles, nanoarticles
• CPC Class Codes: B32B 2255/26 Polymeric coating
• CPC Class Codes: B32B 2305/00 Condition, form or state of the layers or laminate
• CPC Class Codes: B32B 2307/724 Permeability to gases, adsorption
• CPC Class Codes: B32B 2307/7265 Non-permeable
• CPC Class Codes: B32B 25/20 comprising silicone rubber
• CPC Class Codes: B32B 27/26 using curing agents
• CPC Class Codes: B32B 27/283 comprising polysiloxanes
• CPC Class Codes: B32B 3/30 characterised by a layer formed with recesses or projections, e.g. hollows, grooves, protuberances, ribs apertured layer B32B3/266; layer with cavities or internal voids B32B3/26
• CPC Class Codes: B32B 37/025 Transfer laminating
• CPC Class Codes: B32B 37/1018 : using only vacuum

Abstract

A molding compact for forming a transdermal absorption sheet on which a needle-shaped protruding part is arranged is a molding compact that is a laminate of: a first member having a needle-shaped recessed part formed on a front surface thereof, the needle-shaped recessed part being an inverse of the needle-shaped protruding part; a second member provided on a back surface of the first member, the second member being composed of a waterproof and moisture-permeable material; and a third member provided on a back surface of the second member, the third member being composed of a rigid body. Provided are a molding compact that makes it possible to prevent leakage of a drug-containing solution filled into the needle-shaped recessed part, and a manufacturing method for a transdermal absorption sheet using the molding compact.

Claims

1. A molding compact for forming a transdermal absorption sheet on which a needle-shaped protruding parts are arranged, the molding compact configured by laminating:

a first member having needle-shaped recessed parts formed on a front surface thereof, the needle-shaped recessed parts being an inverse of the needle-shaped protruding parts;

a second member provided on a back surface of the first member, the second member being composed of a waterproof and moisture-permeable material; and

a third member provided on a back surface of the second member, the third member being composed of a rigid body,

wherein an air permeability of the second member and the third member is 3 seconds/100 cm³ or more and 100 seconds/100 cm³ or less.

2. The molding compact according to claim 1,

wherein the second member is low in liquid permeability compared to the first member and the third member, and the third member is high in rigidity compared to the first member and the second member.

3. The molding compact according to claim 1,

wherein through holes each having a size of 1 μ

m or more and 50 μ

m or less are formed at pointed ends of the needle-shaped recessed parts of the first member.

4. The molding compact according to claim 1,

wherein the waterproof and moisture-permeable material of the second member is a porous material having a pore size of 0.1 μ

m or more and 2.0 μ

m or less.

5. The molding compact according to claim 1,

wherein the first member and the second member are secured by adhesion or suction.

6. A manufacturing method for a transdermal absorption sheet comprising:

a step of filling a solution obtained by mixing a drug and a polysaccharide, into the needle-shaped recessed parts of the molding compact according to claim 1;

a step of making a solidified matter by drying and solidifying the solution filled into the molding compact; and

a step of separating the solidified matter from the molding compact.

7. The manufacturing method for a transdermal absorption sheet according to claim 6,

wherein vacuum suction is performed from a back surface of the third member of the molding compact, in the step of filling the solution.