METHOD AND SYSTEM FOR OPTICAL ANALYSIS

• US 20150241353A1
• Filed: 02/18/2015
• Published: 08/27/2015
• Est. Priority Date: 02/21/2014
• Status: Abandoned Application

• Current Assignee: Kyushu University, Ushio Denki Kabushiki Kaisha
• Original Assignee: Kyushu University, Ushio Denki Kabushiki Kaisha
• Inventors: OKI, Yuji, MORITA, Kinichi
• Application Number:
  US14/625,180
• Publication Number:
  US 20150241353A1
• Time in Patent Office: Days
• US Class Current: 1/1
• CPC Class Codes: B01L 2300/0654 Lenses; Optical fibres
• CPC Class Codes: B01L 2400/0481 squeezing of channels or chambers
• CPC Class Codes: B01L 3/502715 characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
• CPC Class Codes: G01N 2021/0346 Capillary cells; Microcells
• CPC Class Codes: G01N 21/3581 using far infrared light; using Terahertz radiation
• CPC Class Codes: G01N 21/6428 Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" in vivo A61B5/00; immunoassay G01N33/53
• CPC Class Codes: G01N 2201/0221 Portable; cableless; compact; hand-held
• CPC Class Codes: G01N 2201/08 Optical fibres; light guides

Abstract

A method for optical analysis, which enables a point of care testing to optically analyze a specimen with a disposal microchip. The method uses a portable terminal device having a processing unit, a light receiving unit, and a display unit for displaying processing results of the processing unit. The microchip has a light introducing portion and a light emitting portion, but does not have a light source. The specimen is held in an optical path extending from the light introducing portion to the light emitting portion. The specimen is irradiated with light for analysis of the specimen. The method includes preparing another optical path for guiding light emitted from the light emitting portion of the microchip to the light receiving portion, and introducing the light into the light introducing portion.

Claims

1. A method for optical analysis comprising:

preparing a portable terminal device having an operating and calculating unit, a light receiving unit, and a display unit configured to display processing results of the operating and calculating unit;

preparing a microchip having a light inlet portion and a light outlet portion, but having no light source, the microchip being configured to hold a specimen in a first optical path extending from the light inlet portion to the light outlet portion;

preparing a second optical path configured to guide light exiting from the light outlet portion of the microchip to the light receiving unit;

introducing light into the light inlet portion of the microchip to irradiate the specimen in the first optical path with the light;

guiding the light, which is emitted from the irradiated specimen, to the light receiving unit through the second optical path; and

analyzing the light, which is received at the light receiving unit, by the operating and calculating unit.

2. The method according to claim 1, wherein said introducing light into the light inlet portion of the microchip includes using an external light source other than the portable terminal device to introduce the light into the light inlet portion.

3. The method according to claim 2, wherein said introducing light into the light inlet portion of the microchip includes causing the portable terminal device to feed electricity to the external light source.

4. The method according to claim 3, wherein the portable terminal device further includes a control unit configured to control the display unit, and during said introducing light into the light inlet portion of the microchip, the control unit controls the display unit to reduce or stop light emission from the display unit.

5. The method according to claim 4 further including, prior to said introducing light into the light inlet portion of the microchip, determining whether or not a remaining battery energy of the portable terminal device is equal to or greater than a value which is sufficient to feed the electricity to the external light source.

6. The method according to claim 2, wherein light emitted from the external light source is different from light emitted from the display unit in terms of at least one of wavelength and intensity.

7. The method according to claim 2, wherein the light emitted from the external light source includes pulsed light, coherent light, terahertz light, and/or polarized light.

8. The method according to claim 1 further including, prior to said introducing light into the light inlet portion of the microchip, determining whether the light receiving unit functions normally.

17. A program that causes the portable terminal device to perform the method according to claim 1.

9. A system for optical analysis comprising:

a portable terminal device having an operating and calculating unit, a light receiving unit, and a display unit configured to display processing results of the operating and calculating unit;

a microchip having a light inlet portion and a light outlet portion such that a specimen is held in a first optical path extending from the light inlet portion to the light outlet portion, the specimen being irradiated with light for analysis of the specimen; and

a second optical path configured to guide light exiting from the light outlet portion of the microchip to the light receiving unit such that the operating and calculating unit of the portable terminal device analyzes the light which is received at the light receiving unit.

10. The system according to claim 9 further including an external light source configured to receive electricity from the portable terminal device, and to emit the light with which the specimen is irradiated.

11. The system according to claim 9, wherein the second optical path has a light condensing portion configured to enhance an intensity of the light directed to the light receiving unit.

12. The system according to claim 9, wherein the portable terminal device further includes a control unit configured to control the display unit in order to reduce or stop light emission from the display unit.

13. The system according to claim 10 further including a unit for determining whether or not a remaining battery energy of the portable terminal device is equal to or greater than a value which is sufficient to feed the electricity to the external light source.

14. The system according to claim 10, wherein light emitted from the external light source is different from light emitted from the display unit in terms of at least one of wavelength and intensity.

15. The system according to claim 10, wherein the light emitted from the external light source includes pulsed light, coherent light, terahertz light, and/or polarized light.

16. The system according to claim 9 further including a unit for determining, prior to introducing the light into the light inlet portion of the microchip, whether the light receiving unit functions normally.