ELECTROCHEMICAL-BASED ANALYTICAL TEST STRIP WITH BARE INTERFERENT ELECTRODES
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Accused Products
Abstract
An electrochemical-based analytical test strip (“TS”) for the determination of an analyte in a bodily fluid sample includes an electrically insulating substrate, a patterned conductor layer disposed over the electrically-insulating substrate and having an analyte working electrode (“WE”), a bare interferent electrode (“IE”) and a shared counter/reference electrode (“CE”). The TS also includes a patterned insulation layer (“PIL”) with an electrode exposure slot configured to expose the WE, IE and CE, an enzymatic reagent layer disposed on the WE and CE, and a patterned spacer layer (“PSL”). The PIL and the PSL define a sample receiving chamber with a sample-receiving opening. The IE and the CE constitute a first electrode pair configured for measurement of an interferent electrochemical response and the WE and the CE constitute a second electrode pair configured for measurement of an analyte electrochemical response. The WE and the IE are electrically isolated from one another.
16 Citations
40 Claims
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1-20. -20. (canceled)
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21. An electrochemical-based analytical test strip for the determination of an analyte in a bodily fluid sample, the electrochemical-based analytical test strip comprising:
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an electrically insulating substrate; at least one patterned conductor layer disposed over the electrically-insulating base layer, the patterned conductive layer including; at least one analyte working electrode; at least one bare interferent electrode; and a shared counter/reference electrode; an enzymatic reagent layer disposed on the at least one analyte working electrode and the shared counter/reference electrode; and a patterned spacer layer, wherein the patterned spacer layer defines a sample receiving chamber with a sample-receiving opening, and wherein the at least one bare interferent electrode and the shared counter/reference electrode constitute a first electrode pair configured for measurement of an interferent electrochemical response; and wherein the at least one analyte working electrode and the shared counter/reference electrode constitute a second electrode pair configured for measurement of an analyte electrochemical response; and wherein the at least one analyte working electrode and the at least one bare interferent electrode are electrically isolated from one another. - View Dependent Claims (22, 23, 24, 25, 26, 27, 28, 29, 30)
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31. A method for determining an analyte in a bodily fluid sample, the method comprising:
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applying a bodily fluid sample containing at least one interferent to an electrochemical-based analytical test strip with at least one analyte working electrode covered by an enzymatic reagent layer and at least one bare interferent electrode, the at least one working analyte electrode and at least one bare interferent electrode being electrically isolated from one another; measuring an electrochemical response of the bare interferent electrode and an uncorrected electrochemical response of the analyte working electrode; correcting the measured uncorrected electrochemical response of the analyte working electrode based on the electrochemical response of the bare interferent electrode using an algorithm to create a corrected electrochemical response of the analyte working electrode; and determining the analyte based on the corrected electrochemical response. - View Dependent Claims (32, 33, 34, 35, 36, 37, 38, 39, 40)
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Specification