ADHESIVE FUNCTIONAL STRIP FOR TRANSCUTANEOUS FLUORESCENCE MEASUREMENT

• US 20150245799A1
• Filed: 09/04/2013
• Published: 09/03/2015
• Est. Priority Date: 09/13/2012
• Status: Active Grant

• Current Assignee: Lohmann GmbH & Company KG, MediBeacon Inc.
• Original Assignee: Lohmann GmbH & Company KG
• Inventors: Gretz, Norbert, Schock-Kusch, Daniel, Herbertz, Michael, Nittenwilm, Ralf
• Granted Patent: US 9,861,315 B2
• Time in Patent Office: Days
• US Class Current: 1/1
• CPC Class Codes: A61B 2560/0285 Apparatus for single use
• CPC Class Codes: A61B 2562/12 Manufacturing methods specially adapted for producing sensors for in-vivo measurements
• CPC Class Codes: A61B 5/0071 by measuring fluorescence emission
• CPC Class Codes: A61B 5/02 Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters
• CPC Class Codes: A61B 5/201 Assessing renal or kidney functions
• CPC Class Codes: A61B 5/4244 liver
• CPC Class Codes: A61B 5/425 pancreas
• CPC Class Codes: A61B 5/6833 Adhesive patches
• CPC Class Codes: A61B 5/68335 including release sheets or liners
• CPC Class Codes: C08K 3/04 Carbon
• CPC Class Codes: C09J 133/08 Homopolymers or copolymers of acrylic acid esters
• CPC Class Codes: C09J 2301/1242 the opposite adhesive layers being different
• CPC Class Codes: C09J 2301/302 the adhesive being pressure-sensitive, i.e. tacky at temperatures inferior to 30°C
• CPC Class Codes: C09J 2301/408 additives as essential feature of the adhesive layer
• CPC Class Codes: C09J 2400/22 Presence of unspecified polymer
• CPC Class Codes: C09J 2421/00 Presence of unspecified rubber
• CPC Class Codes: C09J 2433/00 Presence of (meth)acrylic polymer
• CPC Class Codes: C09J 2467/006 : in the substrate
• CPC Class Codes: C09J 2483/00 : Presence of polysiloxane
• CPC Class Codes: C09J 2483/005 : in the release coating
• CPC Class Codes: C09J 7/22 : Plastics; Metallised plastics
• CPC Class Codes: C09J 7/38 : Pressure-sensitive adhesives [PSA]
• CPC Class Codes: C09J 7/381 : based on macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds

Abstract

The present invention pertains to a functional patch to be affixed to the skin, with the aim of measuring metabolic disruptions to organs, and general organ functions, of kidneys, liver, heart, pancreas and muscles (lactate), for example—more particularly it concerns the measurement of the glomerular filtration rate (GFR)—and also to a method for producing a functional patch of this kind.

Claims

1. An adhesive functional strip for transcutaneous fluorescence measurement of general organ functions or metabolic organ disorders with the aid of a sensor fastened to the strip, characterised in that the strip consists substantially of a laminate of the following layers:

backing-less transparent transfer adhesive strip or transparent adhesive tape provided on both sides with a pressure-sensitive adhesive coating suitable and approved for applications to the skin

transparent film

at least one light-absorbing pressure-sensitive adhesive layer with at least one recess

stabilising transparent cover.

2. An adhesive functional strip according to claim 1, characterised in that a circumferential sealing frame comprising four sealing strips is applied on its side remote from the skin, the production of which frame is particularly preferably integrated in the production process of the functional patch, and which thus is an integral component of the functional patch which may however also be present either as a separate sealing frame which is to be attached before the application of the sensor or as a sealing frame which is connected to the sensor and therefore is to be fastened simultaneously with the application of the sensor.

3. An adhesive functional strip according to claim 1, characterised in that the transfer adhesive strip or the transparent adhesive tape which is suitable and approved for applications to the skin comprises an adhesive on the basis of either acrylate, silicone or rubber.

4. An adhesive functional strip according to claim 1, characterised in that the at least one light-absorbing pressure-sensitive adhesive layer consists of a soot-pigmented and consequently black adhesive on the basis of acrylate, silicone or rubber.

5. An adhesive functional strip according to claim 1, characterised in that the light-absorbing pressure-sensitive adhesive layer is present in the form of a backing-based adhesive tape provided on both sides with a soot-pigmented and consequently black adhesive on the basis of acrylate, silicone or rubber.

6. An adhesive functional strip according to claim 1, characterised in that the light-absorbing pressure-sensitive adhesive layer(s) contains/contain a recess through which the direct light contact both of the sensor head which is equipped with LED light and also of the photodiode with the skin is made possible.

7. An adhesive functional strip according to claim 1, characterised in that the double-sided light-absorbing adhesive tape contains a plurality of window-shaped recesses located next to one another and separated from one another by light-impermeable webs, through which recesses the direct light contact both of the sensor head equipped with LED light and also of the photodiode with the skin is made possible.

8. An adhesive functional strip according to claim 2, characterised in that the sealing strips consist of a foam coated on both sides with an adhesive on the basis of acrylate, silicone or rubber.

9. An adhesive functional strip according to claim 6, characterised in that the recess(es) is/are produced by a punching process.

10. An adhesive functional strip according to claim 1, characterised in that it is produced in a sequence of lamination and punching operations.

11. An adhesive functional strip according to claim 1, characterised in that it is either capable of being re-used several times or is to be disposed of after a single use.

12. An adhesive functional strip according to claim 1, characterised in that it is used in particular for transcutaneous measurement of the glomerular filtration rate (GFR).

13. An adhesive functional strip according to claim 1, characterised in that it is used either for transcutaneous measurement of liver, heart or pancreas functions or also for measuring lactate or glucose values.