METHODS AND DEVICES FOR THE TREATMENT OF OCULAR DISEASES IN HUMAN SUBJECTS
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Abstract
Methods and devices are provided for targeted non-surgical administration of a drug formulation to the suprachoroidal space (SCS) of the eye of a human subject for the treatment of a posterior ocular disorder or a choroidal malady. In one embodiment, the method comprises inserting a hollow microneedle into the eye at an insertion site and infusing a drug formulation through the inserted microneedle and into the suprachoroidal space of the eye, wherein the infused drug formulation flows within the suprachoroidal space away from the insertion site during the infusion. In one embodiment, the fluid drug formulation comprises drug nanoparticles or microparticles.
112 Citations
261 Claims
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1-241. -241. (canceled)
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242. A method of treating uveitis in a human subject in need thereof, the method comprising,
non-surgically administering an effective amount of a drug formulation comprising an anti-inflammatory drug to the suprachoroidal space (SCS) of the eye of the human subject in need of treatment of the posterior ocular disorder, wherein upon administration, the drug formulation flows away from the insertion site and is substantially localized to the posterior segment of the eye.
- 257. A composition comprising triamcinolone acetonide, carboxymethylcellulose sodium and polysorbate 80.
Specification