IMAGE-GUIDED THERAPY OF A TISSUE
First Claim
1. A method for effecting thermal therapy using an in vivo side fire probe, comprising:
- positioning the side fire probe in a volume in a patient at a target position;
identifying a three-dimensional region of interest at which to apply thermal therapy; and
delivering, by processing circuitry, thermal therapy to the three-dimensional region of interest, wherein delivering thermal therapy comprisesa) activating emissions exiting the side fire probe to at a high power output for a first period of time,b) deactivating emissions exiting the side fire probe for a second period of time, andc) repeating steps a) and b) until determining completion of thermal therapy;
whereindetermining completion of thermal therapy comprises at least one of i) identifying the three-dimensional region of interest has reached a target temperature, and ii) identifying a thermal dose that is based on a temperature history of the three-dimensional region of interest over a specified time period.
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Accused Products
Abstract
Image-guided therapy of a tissue can utilize magnetic resonance imaging (MRI) or another medical imaging device to guide an instrument within the tissue. A workstation can actuate movement of the instrument, and can actuate energy emission and/or cooling of the instrument to effect treatment to the tissue. The workstation and/or an operator of the workstation can be located outside a vicinity of an MRI device or other medical imaging device, and drive means for positioning the instrument can be located within the vicinity of the MRI device or the other medical imaging device. The instrument can be an MRI compatible laser or high-intensity focused ultrasound probe that provides thermal therapy to, e.g., a tissue in a brain of a patient.
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Citations
24 Claims
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1. A method for effecting thermal therapy using an in vivo side fire probe, comprising:
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positioning the side fire probe in a volume in a patient at a target position; identifying a three-dimensional region of interest at which to apply thermal therapy; and delivering, by processing circuitry, thermal therapy to the three-dimensional region of interest, wherein delivering thermal therapy comprises a) activating emissions exiting the side fire probe to at a high power output for a first period of time, b) deactivating emissions exiting the side fire probe for a second period of time, and c) repeating steps a) and b) until determining completion of thermal therapy; wherein determining completion of thermal therapy comprises at least one of i) identifying the three-dimensional region of interest has reached a target temperature, and ii) identifying a thermal dose that is based on a temperature history of the three-dimensional region of interest over a specified time period. - View Dependent Claims (2, 3, 4, 5)
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6. A system for effecting thermal therapy using an in vivo side fire probe, comprising:
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a processor; and a memory having instructions stored thereon, wherein the instructions, when executed by the processor, cause the processor to; identify a three-dimensional region of interest at which to apply thermal therapy within a volume of a patient, wherein the side fire probe is positioned in the volume; identify, based upon one or more of a) a probe type, b) a probe emission style, and c) a depth of the three-dimensional region of interest, a pulsed energy output pattern, wherein the pulsed energy output pattern comprises an active duration and an inactive duration; and cause application of the pulsed energy output pattern to the three-dimensional region of interest, wherein causing application of the pulsed energy output pattern comprises a) activating probe emission for the active duration at the high power output, b) deactivating probe emission for the inactive duration, and c) repeating steps a) and b) while monitoring feedback data until identifying, based upon the feedback data, conclusion of the thermal therapy, wherein the feedback data comprises at least one of temperature-sensitive data and imaging data, and the feedback data is provided by at least one of a magnetic resonance (MR) imaging system and a thermometry imaging system. - View Dependent Claims (7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 20, 23, 24)
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18. A non-transitory computer readable medium having instructions stored thereon, wherein the instructions, when executed by a processor, cause the processor to:
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identify a three-dimensional region of interest at which to apply thermal therapy within a volume of a patient, wherein the probe is positioned in the volume; identify a pulsed energy output pattern, wherein the pulsed energy output pattern comprises an active duration, a target energy level, and an inactive duration; and cause application of the pulsed energy output pattern to the three-dimensional region of interest, wherein causing application of the pulsed energy output pattern comprises a) activating probe emission for the active duration at the target energy level, b) deactivating probe emission for the inactive duration, and c) repeating steps a) and b) while monitoring feedback data, until identifying, within the feedback data, evidence comprising at least one of i) evidence of potential damage to tissue proximate to an emission region of the probe, and ii) evidence of a mismatch between a target depth of treatment and an actual depth of treatment, and d) responsive to identifying the evidence, adjusting at least one of the inactive duration and the target energy level. - View Dependent Claims (19, 21, 22)
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Specification