Multilayer preform obtained by electro-spinning, method for producing a preform as well as use thereof

• US 20150265744A1
• Filed: 06/08/2015
• Published: 09/24/2015
• Est. Priority Date: 10/09/2008
• Status: Abandoned Application

• Current Assignee: Technische Universiteit Eindhoven
• Original Assignee: Technische Universiteit Eindhoven
• Inventors: Baaijens, Franciscus Petrus Thomas
• Application Number:
  US14/733,564
• Publication Number:
  US 20150265744A1
• Time in Patent Office: Days
• US Class Current: 1/1
• CPC Class Codes: A61B 17/11 for performing anastomosis; Buttons for anastomosis
• CPC Class Codes: A61B 2017/00526 Methods of manufacturing
• CPC Class Codes: A61B 2017/1107 for blood vessels
• CPC Class Codes: A61B 2017/1135 End-to-side connections, e.g. T- or Y-connections
• CPC Class Codes: A61F 2/062 Apparatus for the production of blood vessels made from natural tissue or with layers of living cells prostheses made from natural tissue or living cells A61L27/507
• CPC Class Codes: A61F 2/2415 Manufacturing methods
• CPC Class Codes: A61F 2/2418 Scaffolds therefor, e.g. support stents
• CPC Class Codes: A61F 2210/0004 bioabsorbable
• CPC Class Codes: A61F 2210/0076 multilayered, e.g. laminated structures
• CPC Class Codes: A61L 2430/20 for reconstruction of the heart, e.g. heart valves
• CPC Class Codes: A61L 27/56 Porous materials, e.g. foams or sponges
• CPC Class Codes: A61L 27/58 Materials at least partially resorbable by the body
• CPC Class Codes: D01D 5/0007 Electro-spinning non-woven fabrics produced by electro-spinning D04H1/728
• CPC Class Codes: D04H 1/4374 using different kinds of webs, e.g. by layering webs
• CPC Class Codes: D04H 1/43838 Ultrafine fibres, e.g. microfibres
• CPC Class Codes: D04H 1/728 by electro-spinning electro-spinning methods and apparatus D01D5/0007

Abstract

The invention relates a multilayer preform obtained by electro-spinning, which preform is suitable as a scaffold for a prosthesis, which preform comprises layers of different diameter microfibers. The present invention also relates to a method of producing said preform. The present invention also relates to the use of the present preform as a substrate for growing human or animal tissue thereon. The present invention furthermore relates to a method for growing human or animal tissue on a substrate, wherein the present preform is used as the substrate.

Claims

1. A multilayer preform obtained by electro-spinning, which preform is suitable as a scaffold for a cardiovascular prosthesis, which preform comprises layers of microfibers having different diameters in the range of 3 micrometers to 20 micrometers,

wherein the pore sizes within the layer of fibers are in the range of 1 micrometers to 300 micrometers and suitable for cell infiltration and cell ingrowth throughout the thickness of the layer of fibers,

wherein the infiltrated and ingrown cells are capable of forming the cardiovascular prosthesis,

wherein the fibers in the layer of fibers are biodegradable or bioabsorbable polymeric fibers, and

wherein the fibers biodegrade or bioabsorb upon formation of the cardiovascular prosthesis therewith replacing the scaffold and leaving the cardiovascular prosthesis.

2. The preform according to claim 1, wherein the pore size of the at least one layer of microfibers is between 5 and 100 micrometers.

3. The preform according to claim 1, wherein the diameter of the microfibers is in the range of 5 micrometers to 18 micrometers.

4. The preform according to claim 1, wherein the porosity of the layer of microfibers and/or the layer of nanofibers is in the range of 70 to 95%.

5. The preform according to claim 1, wherein the cardiovascular prosthesis is a heart valve prosthesis.