HYBRID SENSOR ARRAY

• US 20150268208A1
• Filed: 03/24/2015
• Published: 09/24/2015
• Est. Priority Date: 12/29/2009
• Status: Abandoned Application

• Current Assignee: Nanosense Incorporated
• Original Assignee: Nanosense Incorporated
• Inventors: RHODES, PAUL A., KHAMIS, SAMUEL M.
• Application Number:
  US14/667,565
• Publication Number:
  US 20150268208A1
• Time in Patent Office: Days
• US Class Current: 1/1
• CPC Class Codes: B82Y 15/00 Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
• CPC Class Codes: G01M 3/20 using special tracer materials, e.g. dye, fluorescent material, radioactive material
• CPC Class Codes: G01N 27/4141 specially adapted for gases
• CPC Class Codes: G01N 27/4145 specially adapted for biomolecules, e.g. gate electrode with immobilised receptors
• CPC Class Codes: G01N 27/4146 involving nanosized elements, e.g. nanotubes, nanowires
• CPC Class Codes: G01N 27/4148 Integrated circuits therefor, e.g. fabricated by CMOS processing CMOS processing per se H01L21/82
• CPC Class Codes: G01N 33/0031 comprising two or more sensors, e.g. a sensor array
• CPC Class Codes: G01N 33/0047 Organic compounds
• CPC Class Codes: G01N 33/54373 involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
• CPC Class Codes: H01L 29/786 Thin film transistors, i.e. transistors with a channel being at least partly a thin film transistors having only the source or the drain region on an insulator layer H01L29/0653; thin film FinFETs H01L29/785
• CPC Class Codes: H10K 10/484 characterised by the channel regions
• CPC Class Codes: H10K 19/10 comprising field-effect transistors
• CPC Class Codes: H10K 85/225 comprising substituents

Abstract

The present invention provides devices, methods and systems to selectively detect the binding of a molecular species to a biomolecule. In its olfactory sensing application, the hybrid sensor arrays of the present invention provide a high dimensional signature of odorants present that is also readily reversible, together enabling the identification and localization of a source analyte in the presence of the background odorant landscape inherent in a real-world setting.

Claims

1. A hybrid sensor array, said hybrid sensor array comprising:

a first hybrid sensor, wherein said first hybrid sensor has a first nanotube field effect transistor (NT FET) and a first companion transistor, wherein said first companion transistor addresses said first NT FET by gating a flow of current thereto; and

a second hybrid sensor, wherein said second hybrid sensor has a second NT FET and a second companion transistor, wherein said second companion transistor addresses said second NT FET by gating the flow of current thereto.

2. The hybrid sensor array of claim 1, wherein the nanotube of said first and said second NT FET may be the same or different and is a member selected from the group consisting of a single conducting nanotube, a single semiconducting nanotube, a mat of semiconducting nanotubes, and a mat of a combination of an intercalated semiconducting NT and a metallic nanotube.

3. The hybrid sensor array of claim 2, wherein said first NT FET and said second NT FET are each a carbon nanotube (CNT) FET.

4. The hybrid sensor array of claim 3, wherein said first CNT FET and said second CNT FET may be the same or different and each is a member of the group consisting of a single wall carbon nanotube (SWCNT), a multiwall carbon nanotube (MWCNT), graphene and a mixture thereof.

5. The hybrid sensor array of claim 4, wherein said first and said second CNT FET are each functionalized with a biomolecule.

6. The hybrid sensor array of claim 5, wherein said functionalized biomolecule is covalently or noncovalently bound to said first and said second CNT FET.

7. The hybrid sensor array of claim 5, wherein said functionalized biomolecule interacts with an analyte.

8. The hybrid sensor array of claim 7, wherein said interaction affects the current flow of said CNT FET.

9. The hybrid sensor array of claim 1, wherein said first companion transistor and said second companion transistor are each a thin film transistor (TFT).

10. The hybrid sensor array of claim 5, wherein said hybrid sensor array consists of at least n hybrid sensors, wherein n is a number in the range of about 4 to about 10⁵.

11. The hybrid sensor array of claim 10, wherein n is between at least 8 hybrid sensors to at least 64 hybrid sensors.

12. The hybrid sensor array of claim 10, wherein n is at least 16 hybrid sensors.

13. The hybrid sensor array of claim 12, wherein said at least 16 hybrid sensor array is a first hybrid sensor array in a first well of a multiwell sensor module.

14. They hybrid sensor array of claim 13, wherein each CNT FET of said at least 16 hybrid sensor array of the first hybrid sensor array is functionalized the same.

15. The hybrid sensor array of claim 13, wherein said sensor module has a second at least 16 hybrid sensor array in a second well of said multiwell sensor module.

16. The hybrid sensor array of claim 15, wherein each of said hybrid sensors of said second hybrid sensor array has a different functionalization than said first at least 16 hybrid sensor array.

17. The hybrid sensor array of claim 15, wherein said multiwell sensor module has y multiwells.

18. The hybrid sensor array of claim 17, wherein y of said multiwell sensor module is 96 wells.

19-31. -31. (canceled)

32. A method for detecting an analyte, said method comprising:

contacting said analyte with a hybrid sensor array, said hybrid sensor array comprising;

a first hybrid sensor, wherein said first hybrid sensor has a first nanotube field effect transistor (NT FET) and a first companion transistor, wherein said first companion transistor addresses said first NT FET by gating a flow of current thereto;

a second hybrid sensor, wherein said second hybrid sensor has a second NT FET and a second companion transistor, wherein said second companion transistor addresses said second CNT FET by gating the flow of current thereto;

affecting the current flow of said first and said second NT FET to generate a signal; and

detecting said signal thereby detecting said analyte.

33-62. -62. (canceled)

63. A distributed leak detection system of a defined geographical location to enable identification of a leak source, said leak detection system comprising:

a plurality of hybrid sensor arrays, wherein each of said hybrid sensor arrays comprises a first hybrid sensor, wherein said first hybrid sensor has a first nanotube field effect transistor (NT FET) and a first companion transistor, wherein said first companion transistor addresses said first NT FET by gating a flow of current thereto;

a second hybrid sensor, wherein said second hybrid sensor has a second NT FET and a second companion transistor, wherein said second companion transistor addresses said second NT FET by gating the flow of current thereto; and

the plurality of hybrid sensor arrays comprising at least one members selected from the group consisting of a stationary, a hand held, a mobile and a portable hybrid sensor array, wherein the plurality of hybrid sensors are recognizable on a map of said defined geographical location, wherein a leak affects the current flow of one of the plurality of hybrid sensors to generate a signal thereby detecting the leak.

64-68. -68. (canceled)