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GLUCOSE-REGULATING POLYPEPTIDES AND METHODS OF MAKING AND USING SAME

  • US 20150274800A1
  • Filed: 12/05/2014
  • Published: 10/01/2015
  • Est. Priority Date: 06/08/2009
  • Status: Active Grant
First Claim
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1. A method of producing a fusion protein comprising a glucose regulating peptide that is at least 90% identical to an amino acid sequence selected from SEQ ID NO:

  • 2, SEQ ID NO;

    3, SEQ ID NO;

    4, SEQ ID NO;

    5, SEQ ID NO;

    6, SEQ ID NO;

    7, SEQ ID NO;

    8, or SEQ ID NO;

    10, wherein said glucose regulating peptide is linked to an extended recombinant polypeptide (XTEN), wherein the XTEN sequence exhibits at least 90% sequence identity to a comparable length of an amino acid sequence selected from the group consisting of the sequences of SEQ ID NOS;

    189-207, comprising;

    (a) providing host cell comprising a recombinant polynucleotide molecule encoding the fusion protein;

    (b) culturing the host cell under conditions permitting the expression of the fusion protein; and

    (c) recovering the fusion protein.

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