SYSTEMS AND METHODS FOR USING GEOMETRY SENSITIVITY INFORMATION FOR GUIDING WORKFLOW

• US 20150278727A1
• Filed: 04/01/2014
• Published: 10/01/2015
• Est. Priority Date: 04/01/2014
• Status: Active Grant

• Current Assignee: Heartflow Inc.
• Original Assignee: Heartflow Inc.
• Inventors: SANKARAN, Sethuraman, GRADY, Leo J., TAYLOR, Charles A.
• Granted Patent: US 9,773,219 B2
• Time in Patent Office: Days
• US Class Current: 1/1
• CPC Class Codes: G06F 30/33 Design verification, e.g. functional simulation or model checking
• CPC Class Codes: G06Q 10/063 Operations research, analysis or management
• CPC Class Codes: G06Q 10/0633 Workflow analysis
• CPC Class Codes: G16B 15/00 ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment
• CPC Class Codes: G16H 50/50 for simulation or modelling of medical disorders

Abstract

Systems and methods are disclosed for using geometry sensitivity information for guiding workflows in order to produce reliable models and quantities of interest. One method includes determining a geometric model associated with a target object; determining one or more quantities of interest; determining sensitivity information associated with one or more subdivisions of the geometric model and the one or more quantities of interest; and generating, using a processor, a workflow based on the sensitivity information.

Claims

1. A computer-implemented method of guiding a workflow, using a computer system, the method comprising:

receiving a geometric model of a patient'"'"'s anatomy, the geometric model being defined by a plurality of geometric parameters;

determining one or more quantities of interest associated with the patient'"'"'s anatomy;

determining a sensitivity value of each of the one or more quantities of interest to changes in values of the geometric parameters of one or more subdivisions of the geometric model; and

generating or modifying, using a processor, a sequence or workflow of user interfaces for enabling a user to interact with the geometric model based on the sensitivity value of the each of the one or more quantities of interest.

2. The method of claim 1, further including:

determining a functional relationship between the one or more quantities of interest and the one or more subdivisions of the geometric model; and

calculating the one or more quantities of interest further based on the determined functional relationship.

3. The method of claim 1, wherein each sensitivity value measures variance calculated based on the one or more quantities of interest.

4. The method of claim 1, further including:

determining the one or more subdivisions of the geometric model based on an interval or one or more features of the geometric model; and

determining associations between the one or more subdivisions of the geometric model.

5. The method of claim 4, further including:

assigning the sensitivity value to the one or more subdivisions of the geometric model based on the associations between the one or more subdivisions of the geometric model.

6. The method of claim 1, further including:

determining one or more types of uncertainty based on the geometric model, wherein each sensitivity value is a measure of the one or more types of uncertainty in the geometric model.

7. The method of claim 1, further including:

determining one or more threshold values associated with each sensitivity value; and

determining one or more sequences of the workflow based on the one or more threshold values being exceeded.

8. The method of claim 7, wherein the one or more sequences of the workflow include one or more representations, user prompts, workflow steps, or a combination thereof,

wherein the one or more representations include highlighting one or more portions of the geometric model based on each sensitivity value, the one or more threshold values, or a combination thereof.

21. The method of claim 1, wherein the one or more quantities of interest include measures of one or more of:

myocardial mass, body surface area, viscosity, inlet aortic flow rate, coronary flow rate, coronary resistance, pressure, fractional flow reserve (FFR), and resistance of outlet aorta.

9. A system of guiding a workflow, the system comprising:

a data storage device storing instructions for guiding a workflow using geometry sensitivity information; and

a processor configured to execute the instructions to perform a method including;

receiving a geometric model of a patient'"'"'s anatomy, the geometric model being defined by a plurality of geometric parameters;

determining one or more quantities of interest associated with the patient'"'"'s anatomy;

determining a sensitivity value of each of the one or more quantities of interest to changes in values of the geometric parameters of one or more subdivisions of the geometric model; and

generating or modifying a sequence or workflow of user interfaces for enabling a user to interact with the geometric model based on the sensitivity value of the each of the one or more quantities of interest.

10. The system of claim 9, wherein the processor is further configured for:

determining a functional relationship between the one or more quantities of interest and the one or more subdivisions of the geometric model; and

calculating the one or more quantities of interest further based on the determined functional relationship.

11. The system of claim 9, wherein each sensitivity value measures variance calculated based on the one or more quantities of interest.

12. The system of claim 9, wherein the processor is further configured for:

determining the one or more subdivisions of the geometric model based on an interval or one or more features of the geometric model; and

determining associations between the one or more subdivisions of the geometric model.

13. The system of claim 12, wherein the processor is further configured for:

assigning the sensitivity value to the one or more subdivisions of the geometric model based on the associations between the one or more subdivisions of the geometric model.

14. The system of claim 9, wherein the processor is further configured for:

determining one or more types of uncertainty based on the geometric model, wherein each sensitivity value is a measure of the one or more types of uncertainty in the geometric model.

15. The system of claim 9, wherein the processor is further configured for:

determining one or more threshold values associated with each sensitivity value; and

determining one or more sequences of the workflow based on the one or more threshold values being exceeded.

16. The system of claim 9, wherein the one or more sequences of the workflow include one or more representations, user prompts, workflow steps, or a combination thereof,

wherein the one or more representations include highlighting one or more portions of the geometric model based on each sensitivity value, the one or more threshold values, or a combination thereof.

22. The system of claim 9, wherein the one or more quantities of interest include measures of one or more of:

myocardial mass, body surface area, viscosity, inlet aortic flow rate, coronary flow rate, coronary resistance, pressure, fractional flow reserve (FFR), and resistance of outlet aorta.

17. A non-transitory computer readable medium for use on a computer system containing computer-executable programming instructions for guiding a workflow using geometry sensitivity information, the method comprising:

receiving a geometric model of a patient'"'"'s anatomy, the geometric model being defined by a plurality of geometric parameters;

determining one or more quantities of interest associated with the patient'"'"'s anatomy;

determining a sensitivity value of each of the one or more quantities of interest to changes in values of the geometric parameters of one or more subdivisions of the geometric model; and

generating or modifying, using a processor, a sequence or workflow of user interfaces for enabling a user to interact with the geometric model based on the sensitivity value of the each of the one or more quantities of interest.

18. The non-transitory computer readable medium of claim 17, further including:

determining a functional relationship between the one or more quantities of interest and the one or more subdivisions of the geometric model; and

calculating the one or more quantities of interest further based on the determined functional relationship.

19. The non-transitory computer readable medium of claim 17, wherein each sensitivity value measures variance calculated based on the one or more parameters.

20. The non-transitory computer readable medium of claim 17, further including:

determining the one or more subdivisions of the geometric model based on an interval or one or more features of the geometric model; and

determining associations between the one or more subdivisions of the geometric model.

23. The non-transitory computer readable medium of claim 17, wherein the one or more quantities of interest include measures of one or more of:

myocardial mass, body surface area, viscosity, inlet aortic flow rate, coronary flow rate, coronary resistance, pressure, fractional flow reserve (FFR), and resistance of outlet aorta.