EMBOLIC DEVICES
First Claim
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1. An hydrogel for implantation comprising:
- a shapeable polymeric filament formed from a combination of precursors comprising trimethylolpropane ethoxylate triacrylamide;
at least one ethylenically unsaturated acrylamide monomer and at least one ethylenically unsaturated methacrylate monomer; and
a crosslinker; and
comprising at least one visualization agent; and
wherein the hydrogel includes no metal support members.
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Abstract
Described herein are apparatus, compositions, systems and methods for occluding vascular structures and vascular malformations with radiopaque hydrogel filaments. The filaments can contain no support members and can be CT and MR compatible. Methods of forming such filaments are also disclosed.
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Citations
22 Claims
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1. An hydrogel for implantation comprising:
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a shapeable polymeric filament formed from a combination of precursors comprising trimethylolpropane ethoxylate triacrylamide;
at least one ethylenically unsaturated acrylamide monomer and at least one ethylenically unsaturated methacrylate monomer; and
a crosslinker; and
comprising at least one visualization agent; andwherein the hydrogel includes no metal support members. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A method of forming a hydrogel comprising:
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a. preparing a polymerization solution comprising trimethylolpropane ethoxylate triacrylamide;
at least one ethylenically unsaturated monomer; and
at least one visualization element in a solvent;b. polymerizing the polymerization solution to create a polymerized hydrogel; and c. drying the polymerized hydrogel thereby forming the hydrogel. - View Dependent Claims (13, 14, 15, 16, 17, 18, 19)
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20. A method of forming a hydrogel comprising:
drying a hydrogel filament, wherein the hydrogel filament is polymerized from a polymerization solution comprising a trimethylolpropane ethoxylate triacrylamide 900 macromer;
at least one ethylenically unsaturated monomer; and
at least one visualization element in a solvent.
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21. A hydrogel filament consisting essentially of about 27% w/w trimethylolpropane ethoxylate triacrylamide 900, about 6% w/w t-butyl acrylamide, about 2% hydroxyethyl methacrylate, about 0.5% w/w N,N-methylenebisacrylamide, about 64% barium sulfate, and about 0.5% 2,2′
- -azobisisobutyronitrile.
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22. A hydrogel filament consisting essentially of about 30% w/w trimethylolpropane ethoxylate triacrylamide 900, about 6% w/w t-butyl acrylamide, about 2% hydroxyethyl methacrylate, about 0.75% w/w N,N-methylenebisacrylamide, about 48% barium sulfate, and about 0.5% 2,2′
- -azobisisobutyronitrile.
Specification