SUBCUTANEOUS CONTROLLED DELIVERY SYSTEM FOR THE TOPICAL ADMINISTRATION OF DRUGS, BIOLOGICAL AGENTS OR THERAPEUTIC AGENTS TO TARGETED AREAS WITHIN THE BODY

• US 20150283371A1
• Filed: 04/04/2014
• Published: 10/08/2015
• Est. Priority Date: 12/16/2011
• Status: Abandoned Application

• Current Assignee: Topicare Incorporated
• Original Assignee: Topicare Incorporated
• Inventors: Raman, Jaishankar
• Application Number:
  US14/245,279
• Publication Number:
  US 20150283371A1
• Time in Patent Office: Days
• US Class Current: 1/1
• CPC Class Codes: A61K 9/0024 Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue compositions for intravenous administration, normal injectable solutions or dispersions for, e.g. subcutaneous administration A61K9/0019; brain implants A61K9/0085; (coated) prostheses, catheters or stents A61L
• CPC Class Codes: A61M 2205/04 implanted
• CPC Class Codes: A61M 2205/3317 Electromagnetic, inductive or dielectric measuring means
• CPC Class Codes: A61M 2205/3584 using modem, internet or bluetooth
• CPC Class Codes: A61M 39/0208 Subcutaneous access sites for injecting or removing fluids transcutaneous access sites A61M39/0247; implantable infusion devices A61M5/14276

Abstract

The present invention is directed to a subcutaneous controlled delivery device that provides for a refillable reservoir port, a release mechanism and tubing that operably connects the reservoir port to the release mechanism. Such a device is capable of being implanted under the dermis of the skin and allows for the controlled release of drugs, biological agents or therapeutic agents to a target site of interest in the body for treatment.

Claims

1. A subcutaneous delivery device comprising:

a reservoir port;

a release mechanism; and

tubing that operably connects the reservoir port to the release mechanism to administer drugs, biological agents or therapeutic agents to a target treatment site in a controlled manner.

2. The device of claim 1, wherein the reservoir port is implanted in a small area near the dermis.

3. The device of claim 1, wherein the reservoir port has a membrane through which the agents are injected.

4. The device of claim 1, wherein the tubing transports the agent from the reservoir port to the site of treatment.

5. The device of claim 1, wherein the release mechanism comprises macro-, micro, or nanopores for local treatment.

6. The device of claim 1, wherein the release mechanism comprises polymeric membranes or silicon based porous surfaces.

7. The device of claim 6, wherein the polymeric membranes are interfaced with 3-dimensional mechanical tissue engineering constructs for release and sustenance of stem cells at the target site for treatment.

8. The device of claim 1, wherein the release mechanism is customizable depending on the desired treatment.

9. The device of claim 1, wherein the reservoir port includes a wireless transmitter/receiver to relay data between the device and a control unit located outside the body.

10. The device of claim 9, wherein the control unit triggers operation of the release mechanism and/or reservoir port.

12. The device of claim 1, wherein the release mechanism at the target site includes a sensor for relying information from the target site to the control unit.