PROCESSES AND INTERMEDIATES FOR PRODUCING AZAINDOLES
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Abstract
The present invention relates to processes and intermediates for the preparation of compounds useful as inhibitors of Janus kinases (JAK).
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Citations
111 Claims
- 1. A process for preparing a compound of Formula I:
- 37. A process for preparing a compound of Formula 4:
- 56. A process for preparing a compound of Formula 1:
- 73. A process for preparing a compound of Formula 1:
- 83. A process for preparing a compound of Formula 2
- 85. A process for preparing a compound of Formula 2:
- 99. A process for preparing (R)-2-(2-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-ylamino)-2-methyl-N-(2,2,2-trifluoroethyl)butanamide of Formula Ia:
- 101. A process for preparing 2-(2-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoropyrimidin-4-ylamino)-2-methyl-N-(2,2,2-trifluoroethyl)propanamide of Formula Ib:
- 103. A solid form of (R)-2-(2-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-ylamino)-2-methylbutanoic acid (4a) designated as Form E.
- 105. A solid form of (R)-2-(2-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-ylamino)-2-methylbutanoic acid (4a) designated as Form B.
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108. A solid form of (R)-2-(2-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-ylamino)-2-methylbutanoic acid (4a) designated as Form B.
- 109. A solid form of (R)-2-(2-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-ylamino)-2-methyl-N-(2,2,2-trifluoroethyl)butanamide (Ia) designated as Form A.
Specification