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STRATEGY FOR ENGINEERING VARIOUS 3D TISSUES, ORGANOIDS AND VASCULATURE

  • US 20150284689A1
  • Filed: 10/24/2013
  • Published: 10/08/2015
  • Est. Priority Date: 10/26/2012
  • Status: Abandoned Application
First Claim
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1. A method of generating an organ specific tubular tissue structure, comprising:

  • (a) contacting a stem cell, branching epithelial cell, or branching endothelial cell with one or more cell survival agents or biological active agents to stimulate growth and proliferation;

    (b) contacting the cells with one or more branching agents that promotes formation of tubular tissue branches and/or globular morphology to generate budding tissue;

    (c) combining the bud tissue with tissue specific mesenchyme in a biocompatible matrix; and

    (d) culturing the combination to form an organ specific tubular tissue structure from which the tissue specific mesenchyme was obtain in vitro.

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