ANTIBACTERIAL COMPOUNDS AND BIOLOGICAL APPLICATIONS THEREOF
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Accused Products
Abstract
The invention relates to compounds of formulae (Ia), (Ib) or (Ic) wherein, A1 and A2, identical or different, are H, (C1-C6) alkyl, (C1-C6) fluoroalkyl, (C2-C6) alkenyl, (C2-C6) alkynyl, (C1-C6) alkyl-ORa, (C1-C6) alkyl-SRa, (C1-C6) alkyl-NRaRb, ORa, SRa, NRaRb, or CORa; A3 is H, OH or form a carbonyl with A4; A4 is H, OH or form a carbonyl with A3; A5 is H, CRaRbOH, F, OH or forms a double bond with X in the case where X is CH; A6 is H or F; X is CH2, CHF, CF2, CHOH, O, S, NRa or a simple bond, or X is CH in the case where A5 forms with X a double bond; Y is P(O)(ORa)(ORb) or P(O)(ORa)(NRaRb); V is O or S; A7 is H, (C1-C6) alkyl, (C1-C6) fluoroalkyl, (C2-C6) alkenyl, (C2-C6) alkynyl or (C1-C6) alkyl-ORa; A8 is OH or H, Ra and Rb, identical or different, are H, (C1-C6) alkyl, (C1-C6) fluoroalkyl, (C1-C6) alkyl-OH or (C1-C6) alkyl-O—(C1-C6) alkyl; and their addition salts thereof with acids and bases, their preparation and their use in the antibacterial prevention and therapy, used alone or in association with antibacterials, antivirulence agents or drugs reinforcing the host innate immunity.
6 Citations
23 Claims
- 1. The compounds having the general formula (I)
Specification