MICROFLUIDIC DEVICES FOR LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY AND MICROSCOPIC IMAGING
First Claim
1. An apparatus comprising:
- a first wafer, the first wafer defining a sample input hole; and
a second wafer, the first wafer and the second wafer defining a first channel, the first channel including a first end and a second end, the first end of the first channel proximate the sample input hole, the first channel configured to contain separation media; and
an emitter, the emitter being disposed between the first wafer and the second wafer, the second end of the first channel proximate the emitter.
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Abstract
This disclosure provides systems, methods, and apparatus for integration of microscopic imaging and liquid chromatography-mass spectrometry on a microfluidic device. In one aspect, an apparatus includes a first wafer, a second wafer, and an emitter. The emitter is disposed between the first wafer and the second wafer. The first wafer defines a sample input hole. The first wafer and the second wafer define a first channel, the first channel including a first end and a second end. The first end of the first channel is proximate the sample input hole. The first channel is configured to contain separation media. The second end of the first channel is proximate the emitter.
33 Citations
20 Claims
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1. An apparatus comprising:
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a first wafer, the first wafer defining a sample input hole; and a second wafer, the first wafer and the second wafer defining a first channel, the first channel including a first end and a second end, the first end of the first channel proximate the sample input hole, the first channel configured to contain separation media; and an emitter, the emitter being disposed between the first wafer and the second wafer, the second end of the first channel proximate the emitter. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
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17. An apparatus comprising:
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an emitter; a first wafer; a second wafer, the first wafer and the second wafer defining a sample input hole, the first wafer and the second wafer defining a first exit channel having a first end and a second end, the emitter being disposed between the first wafer and the second wafer, the second end of the first exit channel proximate the emitter; and a transparent wafer, the second wafer and the transparent wafer defining a first channel having a first end and a second end, the first end of the first channel proximate the sample input hole, the second end of the first channel proximate the first end of the first exit channel, the first channel being configured to contain separation media. - View Dependent Claims (18, 19, 20)
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Specification