Surfactant Systems for Zinc Containing Compositions

• US 20150297500A1
• Filed: 12/06/2012
• Published: 10/22/2015
• Est. Priority Date: 12/06/2012
• Status: Active Application

• Current Assignee: Colgate-Palmolive Company
• Original Assignee: Colgate-Palmolive Company
• Inventors: ROBINSON, Richard Scott, JOSIAS, Wilbens
• Application Number:
  US14/649,557
• Publication Number:
  US 20150297500A1
• Time in Patent Office: Days
• US Class Current: 1/1
• CPC Class Codes: A61K 8/19 containing inorganic ingredients
• CPC Class Codes: A61K 8/27 Zinc; Compounds thereof
• CPC Class Codes: A61K 8/416 Quaternary ammonium compounds A61K8/35 takes precedence
• CPC Class Codes: A61K 8/44 Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
• CPC Class Codes: A61K 8/442 substituted by amido group(s)
• CPC Class Codes: A61K 8/58 containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur or phosphorus
• CPC Class Codes: A61K 8/90 Block copolymers A61K8/89 takes precedence
• CPC Class Codes: A61Q 11/00 Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Abstract

Disclosed are oral care compositions comprising an orally acceptable vehicle, a basic amino acid in free or salt form, particles of precipitated calcium carbonate, a source of zinc ions, and a surfactant system selected from at least one of a poloxamer nonionic surfactant and a betaine zwitterionic surfactant or a mixture thereof.

Claims

1. An oral care composition comprising an orally acceptable vehicle, a basic amino acid in free or salt form, calcium carbonate, a source of zinc ions, and at least one surfactant selected from a nonionic block copolymer surfactant and a betaine zwitterionic surfactant or a mixture thereof.

2. The oral care composition according to claim 1 wherein the nonionic block copolymer surfactant is present in an amount of from 0.25 to 2 wt % based on the weight of the oral care composition.

3. The oral care composition according to claim 2 wherein the nonionic block copolymer surfactant is present in an amount of from 0.5 to 1.5 wt % based on the weight of the oral care composition.

4. The oral care composition according to claim 3 wherein the nonionic block copolymer surfactant is present in an amount of about 1 wt % based on the weight of the oral care composition.

5. The oral care composition according to claim 1 wherein the nonionic block copolymer surfactant has a polyoxypropylene molecular mass of from 3000 to 5000 g/mol and a polyoxyethylene content of from 60 to 80 mol %.

6. The oral care composition according to claim 1, wherein the nonionic block copolymer surfactant comprises a poloxamer.

7. The oral care composition according to claim 6 wherein the poloxamer nonionic surfactant comprises poloxamer 407.

8. The oral care composition according to claim 1 wherein the betaine zwitterionic surfactant is present in an amount of from 0.25 to 2 wt % based on the weight of the oral care composition.

9. The oral care composition according to claim 8 wherein the betaine zwitterionic surfactant is present in an amount of from 0.5 to 1.5 wt % based on the weight of the oral care composition.

10. The oral care composition according to claim 9 wherein the betaine zwitterionic surfactant is present in an amount of about 1 wt % based on the weight of the oral care composition.

11. The oral care composition according to claim 1 wherein the betaine zwitterionic surfactant comprises a C₈-C₁₆ amidopropyl betaine.

12. The oral care composition according to claim 11 wherein the betaine zwitterionic surfactant comprises cocamidopropyl betaine.

13. The oral care composition according to claim 1 wherein the calcium carbonate is present in an amount of from 10 to 50 wt % based on the weight of the oral care composition.

14. The oral care composition according to claim 13 wherein the calcium carbonate is present in an amount of from 25 to 40 wt % based on the weight of the oral care composition.

15. The oral care composition according to claim 1 wherein the calcium carbonate has an average particle size of no greater than a dentin tubule of a mammalian tooth.

16. The oral care composition according to claim 1 wherein the calcium carbonate has an average particle size of from 1 to 5 microns.

17. The oral care composition according to claim 1 wherein the calcium carbonate comprises a mixture of first particles having a particle size range of from 1 to 7 microns and second particles having a particle size range of from 0.5 to 6 microns.

18. The oral care composition according to claim 17 wherein the first particles are present in an amount of from 5 to 20 wt % based on the weight of the oral care composition and the second particles are present in an amount of from 5 to 40 wt % based on the weight of the oral care composition.

19. The oral care composition according to claim 18 wherein the first particles are present in an amount of from 5 to 15 wt % based on the weight of the oral care composition and the second particles are present in an amount of from 20 to 30 wt % based on the weight of the oral care composition.

20. The oral care composition according to claim 1 wherein the basic amino acid in free or salt form comprises arginine bicarbonate.

21. The oral care composition according to claim 1 wherein the basic amino acid in free or salt form is present in an amount of from 5 to 15 wt % based on the weight of the oral care composition.

22. The oral care composition according to claim 21 wherein the basic amino acid in free or salt form is present in an amount of from 7 to 12 wt % based on the weight of the oral care composition.

23. The oral care composition according to claim 1 wherein the zinc ion source comprises at least one of zinc citrate, zinc lactate, zinc gluconate or zinc oxide, or any mixture of any two or more thereof.

24. The oral care composition according to claim 23 wherein the zinc ion source is present in an amount of from 0.5 to 3 wt % based on the weight of the oral care composition.

25. The oral care composition according to claim 24 wherein the zinc ion source is present in an amount of from 1 to 2 wt % based on the weight of the oral care composition.

26. The oral care composition according to claim 23 wherein the zinc ion source comprises a mixture of zinc citrate and zinc oxide.

27. The oral care composition according to claim 26 wherein zinc citrate is present in an amount of from 0.25 to 0.75 wt % based on the weight of the oral care composition and zinc oxide is present in an amount of from 0.75 to 1.25 wt % based on the weight of the oral care composition.

28. The oral care composition according to claim 1, wherein the basic amino acid in free or salt form comprises arginine bicarbonate, the zinc ion source comprises zinc oxide, and wherein the composition comprises a nonionic block copolymer surfactant comprising poloxamer 407.

29. The oral care composition according to claim 1, wherein the basic amino acid in free or salt form comprises arginine bicarbonate, the zinc ion source comprises zinc oxide, and wherein the composition comprises a betaine zwitterionic surfactant comprising cocamidopropyl betaine.

30. The oral care composition according to claim 1, wherein the basic amino acid in free or salt form comprises arginine bicarbonate, the zinc ion source comprises a mixture of zinc citrate and zinc oxide, and wherein the composition comprises a nonionic block copolymer surfactant comprising poloxamer 407 and a betaine zwitterionic surfactant comprising cocamidopropyl betaine.

31. The oral care composition according to claim 1 wherein the orally acceptable vehicle comprises sorbitol which is present in an amount of from 12 to 30 wt % based on the weight of the oral care composition.

32. The oral care composition according to claim 31 wherein the sorbitol is present in an amount of from 15 to 25 wt % based on the weight of the oral care composition.

33. The oral care composition according to claim 1 wherein the oral care composition does not comprise any sodium lauryl sulfate.

34. The oral care composition according to claim 33 wherein the oral care composition does not comprise any anionic surfactant.

35. The oral care composition according to claim 1 wherein the composition is formulated into a dentifrice in the form of a paste or gel.

36. The oral care composition according to claim 1 wherein the composition is formulated into a form adapted to be applied undiluted within the oral cavity directly to the surface of a mammalian tooth and to be retained within the cavity on the surface for a period of at least 1 hour for treating or preventing hypersensitivity of the tooth.

37. The oral care composition according to claim 1 for enhancing the uptake of zinc ions by the surface of a mammalian tooth in a method comprising applying the oral care composition to the tooth surface.

38. The oral care composition according to claim 1 for increasing the foaming of the oral care composition in an oral cavity in a method comprising applying the composition to the surface of a mammalian tooth in the oral cavity.

39. A method of reducing dental sensitivity comprising applying to the surface of a mammalian tooth an oral care composition of claim 1.

40. A method of occluding a dentin tubule of a mammalian tooth comprising applying to the tooth surface a composition according to claim 1.

41. A method of enhancing the uptake of zinc ions to a mammalian tooth comprising applying to the tooth surface a composition according to claim 1.

42-54. -54. (canceled)