Apparatus and Method to Determine the Blood Sedimentation Rate and Other Parameters Connected Thereto

• US 20150300937A1
• Filed: 07/19/2013
• Published: 10/22/2015
• Est. Priority Date: 07/31/2012
• Status: Active Grant

• Current Assignee: Alifax S.r.l.
• Original Assignee: Alifax Holding SPA
• Inventors: Galiano, Paolo
• Granted Patent: US 9,494,507 B2
• Time in Patent Office: Days
• US Class Current: 1/1
• CPC Class Codes: G01N 15/05 in blood

Abstract

An apparatus to determine the blood sedimentation rate and other parameters connected thereto, carried out by emitting, by means of emitter means, a beam of radiations which passes through a sample being examined, and by detecting, by means of receiver means, the beam of radiations after they have passed through said sample, comprising a reading chamber associated to at least a tube connected to a feed of the sample to be analyzed. Said reading chamber is at least partly transparent to radiations in a certain range of wavelengths, and has at least a substantially rectilinear segment of reduced size into which the sample to be analyzed is introduced. The reading chamber consists of a tube made of plastic material, or glass, defining a capillary channel coupled to said tube in fluidic continuity.

Claims

1. Apparatus to determine the blood sedimentation rate and other parameters connected thereto, carried out by emitting, by means of emitter means, a beam of radiations which passes through a sample being examined, and by detecting, by means of receiver means, the beam of radiations after they have passed through said sample, comprising a reading chamber associated to at least a tube connected to a feed of the sample to be analyzed, said reading chamber being at least partly transparent to radiations in a certain range of wavelengths, and having at least a substantially rectilinear segment of reduced size into which the sample to be analyzed is introduced, wherein the reading chamber consists of a body made of plastic material, or glass, having an entrance hole and an exit hole able to be selectively coupled to respective feed and discharge ends of said tube, a through transit channel of a capillary size being defined between said entrance hole and said exit hole for the passage of the blood sample to be analyzed.

2. Apparatus as in claim 1, wherein said plastic material is acrylic material.

3. Apparatus as in claim 1, wherein said body with a through transit channel has at least a flat surface facing, during use, the emitter means and/or the receiver means.

4. Apparatus as in claim 3, wherein said at least one flat surface is worked so as to be transparent non-diffusive.

5. Apparatus as in claim 1, wherein said body with through transit channel is housed inside a rigid container.

6. Apparatus as in claim 5, wherein said rigid container defines housing seatings for segments of the tube upstream and downstream of the body with through transit channel.

7. Apparatus as in claim 5, wherein said rigid container has means defining the path of the radiations which pass through the body with through transit channel.

8. Apparatus as in claim 1, characterized in that wherein, in correspondence to the position of the body with through transit channel, said rigid container has a positioning through hole.

9. Apparatus as in claim 8, wherein said through hole is closed on at least one side by transparent lenses.

10. Apparatus as in claim 1, wherein it comprises at least a collimator lens disposed between the emitter means and the body with through transit channel.

11. Apparatus as in claim 1, wherein said radiations are chosen among electromagnetic waves, in particular the ones in the visible range, sound waves, or any other type of suitable radiation.

12. Method to determine the blood sedimentation rate and other parameters connected thereto, carried out by emitting, by means of emitter means, a beam of radiations which pass through a sample being examined, and by detecting, by means of receiver means, the beam of radiations after they have passed through said sample, in which a reading chamber is associated to at least a tube connected to a feed of the sample to be analyzed, wherein it provides that a quantity of the sample to be analyzed comprised between 20 and 30 microliters is sent into a reading chamber defined by a body with through transit channel made of plastic material or glass and fluidically connected, by means of a respective entrance hole and exit hole, defining between them said transit channel, to a feed tube;

in that the emitter means and the receiver means are disposed facing flat surfaces of said body with through transit channel at a determined point of the blood flow which corresponds to the end-of-travel of each sample read; and

in that the measurement is carried out on an end portion of the sample after a head part thereof has passed, so that said head part performs the function of washing out the contamination of the previous sample.

13. Method as in claim 12, wherein the volume of the sample to be analyzed in the reading chamber of the body with through transit channel is in the order of 1 microliter.

14. Method as in claim 12, wherein it provides to make measurements of the refraction index of the sample in transit in the body with through transit channel thanks to the difference between the refraction index of the sample and the refraction index of the material that makes up the body with through transit channel.