A SENSOR COMPOSITION FOR ACETONE DETECTION IN BREATH

• US 20150301020A1
• Filed: 03/04/2013
• Published: 10/22/2015
• Est. Priority Date: 04/30/2012
• Status: Active Grant

• Current Assignee: Council of Scientific & Industrial Research
• Original Assignee: Council of Scientific & Industrial Research
• Inventors: Sen, Amarnath, Rana, Subhasis
• Granted Patent: US 9,470,675 B2
• Time in Patent Office: Days
• US Class Current: 1/1
• CPC Class Codes: A61B 5/082 Evaluation by breath analysis, e.g. determination of the chemical composition of exhaled breath A61B5/083, A61B5/091 take precedence
• CPC Class Codes: A61B 5/083 Measuring rate of metabolism by using breath test, e.g. measuring rate of oxygen consumption
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: B01J 19/10 employing sonic or ultrasonic vibrations
• CPC Class Codes: G01N 2033/4975 other than oxygen, carbon dioxide or alcohol, e.g. organic vapours
• CPC Class Codes: G01N 33/497 of gaseous biological material, e.g. breath
• CPC Class Codes: G01N 33/64 involving ketones

Abstract

The present invention provides a composition for acetone detection and a process of preparation thereof. The composition comprises γ-ferric oxide (γ-Fe₂O₃), antimony (Sb) salt, and platinum (Pt). The sensor fabricated using the said composition is selective to low concentration of breath acetone, the biomarker of diabetes, in presence of high amount of moisture normally present in breath. Such semiconductor sensors for diabetes monitoring are inexpensive, rugged, patient-friendly and on the top, non-invasive.

Claims

1. A composition for acetone detection, wherein the said composition comprises:

(a) γ

-ferric oxide (γ

-Fe₂O₃), in the range of 87.5-95.7 wt %

(b) antimony (Sb) salt, in the range of 2.9-9.9 wt %, and

(c) platinum (Pt) in the range of 0.5-2.6 wt %.

2. The composition as claimed in claim 1, wherein antimony salt is incorporated in an oxide, carbonate, nitrate, or any other salt form.

3. The composition as claimed in claim 1, wherein platinum is incorporated in a metallic form, chloride, nitrate, or any other salt form.

7. A process of preparing the composition as claimed in claim 1., wherein the composition is prepared through sonochemical method comprising the steps of:

(a) preparing aqueous solutions of iron(III) nitrate nonahydrate salt [Fe(NO₃)₃.9H₂O], antimony salt and platinum salt finally decomposes to metallic platinum by adding water and hydrochloric acid and heating the solutions at 100°

C.;

(b) mixing the aqueous solutions formed in step (a) in the required proportion such as herein described to form a mixed solution;

(c) sonicating the mixed solution formed in step (b) and adding hydrazine during sonication to produce a precipitate;

(d) centrifuging, washing and drying of the precipitate formed in step (c) to get a γ

-ferric oxide based composition.

8. The process of preparing the composition as claimed in claim 7, wherein antimony salt is incorporated in an oxide, carbonate, nitrate, or any other salt form

9. The process of preparing the composition as claimed in claim 7, wherein platinum is incorporated in a metallic form, chloride, nitrate, or any other salt form.

10. A process of fabricating sensors using the composition as claimed in claim 1, comprising the steps of:

a) mixing the γ

-ferric oxide based composition with isopropanol to form a slurry;

b) taking a substrate and heating it at temperature of 1000°

C. for attaching a gold electrode and a platinum wire to the substrate;

c) taking the slurry as prepared in step (a) and drop coating onto the spinning substrate to make a drop coated substrate;

d) curing the drop coated substrate at a temperature in the range of 200-450°

C.;

e) inserting a kanthal heating coil inside the drop coated substrate; and

,

f) fixing the sensor-coated substrate on a Transistor Outline (TO) type package by wire bonding/soldering to form a sensor.

11. The process as claimed in claim 10, wherein the sensor is made in the form of a thick or a thin film on substrates and/or in a bulk form.

12. The process as claimed in claim 10, wherein the substrate is selected from alumina or insulating materials and are in the form of tube, planar structure or microelectromechanical systems (MEMS) based microheater.

13. The process as claimed in claim 10, wherein the fabricated sensors detects 1 ppm and sub-ppm concentrations of acetone in presence of high amount of moisture.

14. The composition as claimed in claim 1, wherein the composition is used in fabricating sensors for the diagnosis of diabetes and monitoring diabetic patients with abnormal acetone concentration.

15. The composition as claimed in claim 1, wherein γ

-Fe₂O₃ is prepared through sonochemical or any other synthesis route.

4-6. -6. (canceled)