INFANT NUTRITION FOR IMPROVING FATTY ACID COMPOSITION OF BRAIN MEMBRANES
First Claim
1. A method for altering brain membrane fatty acid composition selected from the group consisting of i) increasing brain membrane fluidity, ii) increasing brain membrane PUFA, iii) increasing brain membrane LC-PUFA, iv) decreasing brain membrane ratio of n6/n3 LC-PUFA, v) decreasing brain membrane ratio of n6/n3 PUFA, vi) increasing brain membrane n3 PUFA, vii) increasing brain membrane n3 LC-PUFA and viii) increasing brain membrane DHA, in a human subject, the method comprising administering to the human subject a nutritional composition comprising:
- 10 to 50 wt. % vegetable lipids based on dry weight of the composition, and lipid globules with a core comprising said vegetable lipids wherein said lipid globules have;
(i) a volume-weighted mode diameter above 1.0 μ
m, and/or(ii) a diameter of 2 to 12 μ
m in an amount of at least 45 volume % based on total lipid.
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Abstract
The present invention relates to infant nutrition, in particular to infant nutrition comprising special lipid globules for improvement of the fatty acid composition in brain membranes.
12 Citations
20 Claims
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1. A method for altering brain membrane fatty acid composition selected from the group consisting of i) increasing brain membrane fluidity, ii) increasing brain membrane PUFA, iii) increasing brain membrane LC-PUFA, iv) decreasing brain membrane ratio of n6/n3 LC-PUFA, v) decreasing brain membrane ratio of n6/n3 PUFA, vi) increasing brain membrane n3 PUFA, vii) increasing brain membrane n3 LC-PUFA and viii) increasing brain membrane DHA, in a human subject, the method comprising administering to the human subject a nutritional composition comprising:
- 10 to 50 wt. % vegetable lipids based on dry weight of the composition, and lipid globules with a core comprising said vegetable lipids wherein said lipid globules have;
(i) a volume-weighted mode diameter above 1.0 μ
m, and/or(ii) a diameter of 2 to 12 μ
m in an amount of at least 45 volume % based on total lipid. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
- 10 to 50 wt. % vegetable lipids based on dry weight of the composition, and lipid globules with a core comprising said vegetable lipids wherein said lipid globules have;
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11. A method for amelioration of cognitive performance in a human subject above 36 months of age, the method comprising administering to said human subject at an age between 0 and 36 months a nutritional composition comprising:
- 10 to 50 wt. % vegetable lipids based on dry weight of the composition, and lipid globules with a core comprising said vegetable lipids, wherein said lipid globules have;
(i) a volume-weighted mode diameter above 1.0 μ
m, and/or(ii) a diameter of 2 to 12 μ
m in an amount of at least 45 volume % based on total lipid. - View Dependent Claims (12, 13, 14, 15, 16)
- 10 to 50 wt. % vegetable lipids based on dry weight of the composition, and lipid globules with a core comprising said vegetable lipids, wherein said lipid globules have;
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17. A method for the prevention and/or treatment of a disorder associated with decreased brain membrane fluidity and/or associated with decreased brain membrane PUFA content and/or LC-PUFA content and/or increased ratio of n6/n3 LC-PUFA, and/or increased ratio of n6/n3 PUFA, the method comprising administering to a human subject in need thereof a nutritional composition comprising:
- 10 to 50 wt. % vegetable lipids based on dry weight of the composition, and lipid globules with a core comprising said vegetable lipids wherein said lipid globules have;
(i) a volume-weighted mode diameter above 1.0 μ
m, and/or(ii) a diameter of 2 to 12 μ
m in an amount of at least 45 volume % based on total lipid. - View Dependent Claims (18, 19)
- 10 to 50 wt. % vegetable lipids based on dry weight of the composition, and lipid globules with a core comprising said vegetable lipids wherein said lipid globules have;
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20. A nutritional composition comprising:
- 10 to 50 wt. % vegetable lipids based on dry weight of the composition, and lipid globules with a core comprising said vegetable lipids wherein said lipid globules have;
(i) a volume-weighted mode diameter above 1.0 μ
m, and/or(ii) a diameter of 2 to 12 μ
m in an amount of at least 45 volume % based on total lipid.
- 10 to 50 wt. % vegetable lipids based on dry weight of the composition, and lipid globules with a core comprising said vegetable lipids wherein said lipid globules have;
Specification